Kathryn A. Whitehead
Kathryn A. Whitehead
Associate Professor of Chemical Engineering, Carnegie Mellon University
Verified email at cmu.edu - Homepage
TitleCited byYear
Knocking down barriers: advances in siRNA delivery
KA Whitehead, R Langer, DG Anderson
Nature Reviews Drug Discovery 8 (2), 129-138, 2009
25482009
Lipid-like materials for low-dose, in vivo gene silencing
KT Love, KP Mahon, CG Levins, KA Whitehead, W Querbes, JR Dorkin, ...
Proceedings of the National Academy of Sciences 107 (5), 1864-1869, 2010
6662010
Rapid discovery of potent siRNA-containing lipid nanoparticles enabled by controlled microfluidic formulation
D Chen, KT Love, Y Chen, AA Eltoukhy, C Kastrup, G Sahay, A Jeon, ...
Journal of the American Chemical Society 134 (16), 6948-6951, 2012
2442012
Managing diabetes with nanomedicine: challenges and opportunities
O Veiseh, BC Tang, KA Whitehead, DG Anderson, R Langer
Nature Reviews Drug Discovery 14 (1), 45-57, 2015
2332015
Degradable lipid nanoparticles with predictable in vivo siRNA delivery activity
KA Whitehead, JR Dorkin, AJ Vegas, PH Chang, O Veiseh, J Matthews, ...
Nature communications 5, 4277, 2014
2082014
Action and reaction: the biological response to siRNA and its delivery vehicles
RL Kanasty, KA Whitehead, AJ Vegas, DG Anderson
Molecular Therapy 20 (3), 513-524, 2012
1972012
Combinatorial synthesis of chemically diverse core-shell nanoparticles for intracellular delivery
DJ Siegwart, KA Whitehead, L Nuhn, G Sahay, H Cheng, S Jiang, M Ma, ...
Proceedings of the National Academy of Sciences 108 (32), 12996-13001, 2011
1802011
Silencing or stimulation? siRNA delivery and the immune system
KA Whitehead, JE Dahlman, RS Langer, DG Anderson
Annual review of chemical and biomolecular engineering 2, 77-96, 2011
1472011
Aminoalcohol lipidoids and uses thereof
KP Mahon, KT Love, CG Levins, KA Whitehead, RS Langer, DG Anderson
US Patent 8,450,298, 2013
1232013
Oral delivery of macromolecules using intestinal patches: applications for insulin delivery
K Whitehead, Z Shen, S Mitragotri
Journal of controlled release 98 (1), 37-45, 2004
1232004
Advances in drug delivery
BP Timko, K Whitehead, W Gao, DS Kohane, O Farokhzad, D Anderson, ...
Annual Review of Materials Research 41, 1-20, 2011
1222011
Safe and effective permeation enhancers for oral drug delivery
K Whitehead, N Karr, S Mitragotri
Pharmaceutical research 25 (8), 1782-1788, 2008
1052008
Systemic RNAi-mediated Gene Silencing in Nonhuman Primate and Rodent Myeloid Cells
TI Novobrantseva, A Borodovsky, J Wong, B Klebanov, M Zafari, K Yucius, ...
Molecular Therapy—Nucleic Acids 1 (1), e4, 2012
982012
Nanoparticulate cellular patches for cell-mediated tumoritropic delivery
H Cheng, CJ Kastrup, R Ramanathan, DJ Siegwart, M Ma, SR Bogatyrev, ...
ACS nano 4 (2), 625-631, 2010
932010
In vitro–in vivo translation of lipid nanoparticles for hepatocellular siRNA delivery
KA Whitehead, J Matthews, PH Chang, F Niroui, JR Dorkin, M Severgnini, ...
ACS nano 6 (8), 6922-6929, 2012
682012
Aminoalcohol lipidoids and uses thereof
KP Mahon, KT Love, CG Levins, KA Whitehead, RS Langer, DG Anderson
US Patent 8,969,353, 2015
642015
Combinatorial approach to determine functional group effects on lipidoid-mediated siRNA delivery
KP Mahon, KT Love, KA Whitehead, J Qin, A Akinc, E Leshchiner, ...
Bioconjugate chemistry 21 (8), 1448-1454, 2010
642010
Tools for translation: non-viral materials for therapeutic mRNA delivery
KA Hajj, KA Whitehead
Nature Reviews Materials 2 (10), 17056, 2017
632017
Mechanistic analysis of chemical permeation enhancers for oral drug delivery
K Whitehead, S Mitragotri
Pharmaceutical research 25 (6), 1412-1419, 2008
562008
Synergistic silencing: combinations of lipid-like materials for efficacious siRNA delivery
KA Whitehead, G Sahay, GZ Li, KT Love, CA Alabi, M Ma, C Zurenko, ...
Molecular Therapy 19 (9), 1688-1694, 2011
532011
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