| Optimization of lipid nanoparticle formulations for mRNA delivery in vivo with fractional factorial and definitive screening designs KJ Kauffman, JR Dorkin, JH Yang, MW Heartlein, F DeRosa, FF Mir, ... Nano letters 15 (11), 7300-7306, 2015 | 589 | 2015 |
| Delivery technologies for genome editing H Yin, KJ Kauffman, DG Anderson Nature reviews Drug discovery 16 (6), 387-399, 2017 | 561 | 2017 |
| Structure-guided chemical modification of guide RNA enables potent non-viral in vivo genome editing H Yin, CQ Song, S Suresh, Q Wu, S Walsh, LH Rhym, E Mintzer, ... Nature biotechnology 35 (12), 1179-1187, 2017 | 467 | 2017 |
| Materials for non-viral intracellular delivery of messenger RNA therapeutics KJ Kauffman, MJ Webber, DG Anderson Journal of Controlled Release 240, 227-234, 2016 | 363 | 2016 |
| Polymer–lipid nanoparticles for systemic delivery of mRNA to the lungs JC Kaczmarek, AK Patel, KJ Kauffman, OS Fenton, MJ Webber, ... Angewandte Chemie 128 (44), 14012-14016, 2016 | 287 | 2016 |
| Inhaled nanoformulated mRNA polyplexes for protein production in lung epithelium AK Patel, JC Kaczmarek, S Bose, KJ Kauffman, F Mir, MW Heartlein, ... Advanced Materials 31 (8), 1805116, 2019 | 280 | 2019 |
| Barcoded nanoparticles for high throughput in vivo discovery of targeted therapeutics JE Dahlman, KJ Kauffman, Y Xing, TE Shaw, FF Mir, CC Dlott, R Langer, ... Proceedings of the National Academy of Sciences 114 (8), 2060-2065, 2017 | 225 | 2017 |
| Bioinspired alkenyl amino alcohol ionizable lipid materials for highly potent in vivo mRNA delivery OS Fenton, KJ Kauffman, RL McClellan, EA Appel, JR Dorkin, MW Tibbitt, ... Advanced materials (Deerfield Beach, Fla.) 28 (15), 2939, 2016 | 209 | 2016 |
| Endothelial TGF-β signalling drives vascular inflammation and atherosclerosis PY Chen, L Qin, G Li, Z Wang, JE Dahlman, J Malagon-Lopez, S Gujja, ... Nature metabolism 1 (9), 912-926, 2019 | 199 | 2019 |
| Synthesis and biological evaluation of ionizable lipid materials for the in vivo delivery of messenger RNA to B lymphocytes OS Fenton, KJ Kauffman, JC Kaczmarek, RL McClellan, S Jhunjhunwala, ... Advanced Materials 29 (33), 1606944, 2017 | 191 | 2017 |
| RNAi targeting multiple cell adhesion molecules reduces immune cell recruitment and vascular inflammation after myocardial infarction HB Sager, P Dutta, JE Dahlman, M Hulsmans, G Courties, Y Sun, T Heidt, ... Science translational medicine 8 (342), 342ra80-342ra80, 2016 | 187 | 2016 |
| Efficacy and immunogenicity of unmodified and pseudouridine-modified mRNA delivered systemically with lipid nanoparticles in vivo KJ Kauffman, FF Mir, S Jhunjhunwala, JC Kaczmarek, JE Hurtado, ... Biomaterials 109, 78-87, 2016 | 175 | 2016 |
| Optimization of a degradable polymer–lipid nanoparticle for potent systemic delivery of mRNA to the lung endothelium and immune cells JC Kaczmarek, KJ Kauffman, OS Fenton, K Sadtler, AK Patel, ... Nano letters 18 (10), 6449-6454, 2018 | 167 | 2018 |
| Therapeutic efficacy in a hemophilia B model using a biosynthetic mRNA liver depot system F DeRosa, B Guild, S Karve, L Smith, K Love, JR Dorkin, KJ Kauffman, ... Gene therapy 23 (10), 699-707, 2016 | 155 | 2016 |
| Uremic toxin indoxyl sulfate promotes proinflammatory macrophage activation via the interplay of OATP2B1 and Dll4-Notch signaling: Potential mechanism for accelerated … T Nakano, S Katsuki, M Chen, JL Decano, A Halu, LH Lee, DVS Pestana, ... Circulation 139 (1), 78-96, 2019 | 149 | 2019 |
| Synthesis and characterization of acetalated dextran polymer and microparticles with ethanol as a degradation product KJ Kauffman, C Do, S Sharma, MD Gallovic, EM Bachelder, KM Ainslie ACS applied materials & interfaces 4 (8), 4149-4155, 2012 | 99 | 2012 |
| Cell-cycle-targeting MicroRNAs as therapeutic tools against refractory cancers P Hydbring, Y Wang, A Fassl, X Li, V Matia, T Otto, YJ Choi, KE Sweeney, ... Cancer cell 31 (4), 576-590. e8, 2017 | 95 | 2017 |
| Synthesis, optimization, and characterization of camptothecin-loaded acetalated dextran porous microparticles for pulmonary delivery SA Meenach, YJ Kim, KJ Kauffman, N Kanthamneni, EM Bachelder, ... Molecular pharmaceutics 9 (2), 290-298, 2012 | 85 | 2012 |
| Optimization of rapamycin-loaded acetalated dextran microparticles for immunosuppression KJ Kauffman, N Kanthamneni, SA Meenach, BC Pierson, EM Bachelder, ... International journal of pharmaceutics 422 (1-2), 356-363, 2012 | 79 | 2012 |
| Rapid, single-cell analysis and discovery of vectored mRNA transfection in vivo with a loxP-flanked tdTomato reporter mouse KJ Kauffman, MA Oberli, JR Dorkin, JE Hurtado, JC Kaczmarek, ... Molecular therapy-Nucleic acids 10, 55-63, 2018 | 78 | 2018 |
