| FAK alters invadopodia and focal adhesion composition and dynamics to regulate breast cancer invasion KT Chan, CL Cortesio, A Huttenlocher Journal of Cell Biology 185 (2), 357-370, 2009 | 281 | 2009 |
| Regulation of adhesion dynamics by calpain-mediated proteolysis of focal adhesion kinase (FAK) KT Chan, DA Bennin, A Huttenlocher Journal of Biological Chemistry 285 (15), 11418-11426, 2010 | 263 | 2010 |
| Calpain 2 and PTP1B function in a novel pathway with Src to regulate invadopodia dynamics and breast cancer cell invasion CL Cortesio, KT Chan, BJ Perrin, NO Burton, S Zhang, ZY Zhang, ... The Journal of cell biology 180 (5), 957-971, 2008 | 231 | 2008 |
| Unraveling the enigma: progress towards understanding the coronin family of actin regulators KT Chan, SJ Creed, JE Bear Trends in cell biology 21 (8), 481-488, 2011 | 168 | 2011 |
| Ribosomal proteins and human diseases: molecular mechanisms and targeted therapy J Kang, N Brajanovski, KT Chan, J Xuan, RB Pearson, E Sanij Signal transduction and targeted therapy 6 (1), 323, 2021 | 166 | 2021 |
| LKB1/STK11 inactivation leads to expansion of a prometastatic tumor subpopulation in melanoma W Liu, KB Monahan, AD Pfefferle, T Shimamura, J Sorrentino, KT Chan, ... Cancer cell 21 (6), 751-764, 2012 | 140 | 2012 |
| CX-5461 activates the DNA damage response and demonstrates therapeutic efficacy in high-grade serous ovarian cancer E Sanij, KM Hannan, J Xuan, S Yan, JE Ahern, AS Trigos, N Brajanovski, ... Nature communications 11 (1), 2641, 2020 | 112 | 2020 |
| Cystathionine β-synthase in physiology and cancer H Zhu, S Blake, KT Chan, RB Pearson, J Kang BioMed research international 2018, 2018 | 106 | 2018 |
| Inhibition of RNA polymerase I transcription initiation by CX-5461 activates non-canonical ATM/ATR signaling J Quin, KT Chan, JR Devlin, DP Cameron, J Diesch, C Cullinane, J Ahern, ... Oncotarget 7 (31), 49800, 2016 | 104 | 2016 |
| Regulation of PRMT5–MDM4 axis is critical in the response to CDK4/6 inhibitors in melanoma S AbuHammad, C Cullinane, C Martin, Z Bacolas, T Ward, H Chen, ... Proceedings of the National Academy of Sciences 116 (36), 17990-18000, 2019 | 88 | 2019 |
| β2-adrenoceptor signaling regulates invadopodia formation to enhance tumor cell invasion SJ Creed, CP Le, M Hassan, CK Pon, S Albold, KT Chan, ME Berginski, ... Breast cancer research 17, 1-12, 2015 | 86 | 2015 |
| Type Iγ PIP kinase is a novel uropod component that regulates rear retraction during neutrophil chemotaxis MA Lokuta, MA Senetar, DA Bennin, PA Nuzzi, KT Chan, VL Ott, ... Molecular biology of the cell 18 (12), 5069-5080, 2007 | 69 | 2007 |
| Oncogene-induced senescence: From biology to therapy H Zhu, S Blake, FK Kusuma, RB Pearson, J Kang, KT Chan Mechanisms of ageing and development 187, 111229, 2020 | 65 | 2020 |
| Integrins in cell migration KT Chan, CL Cortesio, A Huttenlocher Methods in enzymology 426, 47-67, 2007 | 50 | 2007 |
| LKB1 loss in melanoma disrupts directional migration toward extracellular matrix cues KT Chan, SB Asokan, SJ King, T Bo, ES Dubose, W Liu, ME Berginski, ... Journal of Cell Biology 207 (2), 299-315, 2014 | 49 | 2014 |
| A functional genetic screen defines the AKT-induced senescence signaling network KT Chan, S Blake, H Zhu, J Kang, AS Trigos, PB Madhamshettiwar, ... Cell Death & Differentiation 27 (2), 725-741, 2020 | 48 | 2020 |
| Coronin 1C harbours a second actin-binding site that confers co-operative binding to F-actin KT Chan, DW Roadcap, N Holoweckyj, JE Bear Biochemical Journal 444 (1), 89-96, 2012 | 41 | 2012 |
| The potential of targeting ribosome biogenesis in high-grade serous ovarian cancer S Yan, D Frank, J Son, KM Hannan, RD Hannan, KT Chan, RB Pearson, ... International journal of molecular sciences 18 (1), 210, 2017 | 27 | 2017 |
| The RNA polymerase I transcription inhibitor CX-5461 cooperates with topoisomerase 1 inhibition by enhancing the DNA damage response in homologous recombination-proficient high … S Yan, J Xuan, N Brajanovski, MRC Tancock, PB Madhamshettiwar, ... British Journal of Cancer 124 (3), 616-627, 2021 | 25 | 2021 |
| IL2 inducible T-cell kinase, a novel therapeutic target in melanoma CC Carson, SJ Moschos, SN Edmiston, DB Darr, N Nikolaishvili-Feinberg, ... Clinical Cancer Research 21 (9), 2167-2176, 2015 | 19 | 2015 |
