| An orally bioavailable chemical probe of the lysine methyltransferases EZH2 and EZH1 KD Konze, A Ma, F Li, D Barsyte-Lovejoy, T Parton, CJ MacNevin, F Liu, ... ACS chemical biology 8 (6), 1324-1334, 2013 | 479 | 2013 |
| Selective inhibition of EZH2 and EZH1 enzymatic activity by a small molecule suppresses MLL-rearranged leukemia B Xu, DM On, A Ma, T Parton, KD Konze, SG Pattenden, DF Allison, L Cai, ... Blood, The Journal of the American Society of Hematology 125 (2), 346-357, 2015 | 234 | 2015 |
| Discovery of a first-in-class EZH2 selective degrader A Ma, E Stratikopoulos, KS Park, J Wei, TC Martin, X Yang, M Schwarz, ... Nature chemical biology 16 (2), 214-222, 2020 | 167 | 2020 |
| Discovery of a selective, substrate-competitive inhibitor of the lysine methyltransferase SETD8 A Ma, W Yu, F Li, RM Bleich, JM Herold, KV Butler, JL Norris, V Korboukh, ... Journal of medicinal chemistry 57 (15), 6822-6833, 2014 | 94 | 2014 |
| EZH2 noncanonically binds cMyc and p300 through a cryptic transactivation domain to mediate gene activation and promote oncogenesis J Wang, X Yu, W Gong, X Liu, KS Park, A Ma, YH Tsai, Y Shen, T Onikubo, ... Nature cell biology 24 (3), 384-399, 2022 | 92 | 2022 |
| Epigenetic siRNA and chemical screens identify SETD8 inhibition as a therapeutic strategy for p53 activation in high-risk neuroblastoma V Veschi, Z Liu, TC Voss, L Ozbun, B Gryder, C Yan, Y Hu, A Ma, J Jin, ... Cancer cell 31 (1), 50-63, 2017 | 90 | 2017 |
| Enantioselective organocatalytic Michael addition of malonates to α, β-unsaturated aldehydes in water A Ma, S Zhu, D Ma Tetrahedron Letters 49 (19), 3075-3077, 2008 | 87 | 2008 |
| The lipid kinase PIP5K1C regulates pain signaling and sensitization BD Wright, L Loo, SE Street, A Ma, B Taylor-Blake, MA Stashko, J Jin, ... Neuron 82 (4), 836-847, 2014 | 76 | 2014 |
| Exploiting an allosteric binding site of PRMT3 yields potent and selective inhibitors F Liu, F Li, A Ma, E Dobrovetsky, A Dong, C Gao, I Korboukh, J Liu, D Smil, ... Journal of medicinal chemistry 56 (5), 2110-2124, 2013 | 76 | 2013 |
| Enantioselective synthesis of polysubstituted cyclopentanones by organocatalytic double Michael addition reactions A Ma, D Ma Organic Letters 12 (16), 3634-3637, 2010 | 71 | 2010 |
| Genome-wide profiling of histone H3 lysine 27 and lysine 4 trimethylation in multiple myeloma reveals the importance of Polycomb gene targeting and highlights EZH2 as a … P Agarwal, M Alzrigat, AA Párraga, S Enroth, U Singh, J Ungerstedt, ... Oncotarget 7 (6), 6809, 2016 | 68 | 2016 |
| PHF19 promotes multiple myeloma tumorigenicity through PRC2 activation and broad H3K27me3 domain formation Z Ren, JH Ahn, H Liu, YH Tsai, NV Bhanu, B Koss, DF Allison, A Ma, ... Blood, The Journal of the American Society of Hematology 134 (14), 1176-1189, 2019 | 63 | 2019 |
| Dual inhibition of EZH2 and EZH1 sensitizes PRC2-dependent tumors to proteasome inhibition O Rizq, N Mimura, M Oshima, A Saraya, S Koide, Y Kato, K Aoyama, ... Clinical Cancer Research 23 (16), 4817-4830, 2017 | 63 | 2017 |
| ATRX in-frame fusion neuroblastoma is sensitive to EZH2 inhibition via modulation of neuronal gene signatures ZA Qadeer, D Valle-Garcia, D Hasson, Z Sun, A Cook, C Nguyen, ... Cancer Cell 36 (5), 512-527. e9, 2019 | 62 | 2019 |
| Organocatalytic Michael addition of aldehydes to γ-keto-α, β-unsaturated esters. an efficient entry to versatile chiral building blocks J Wang, A Ma, D Ma Organic Letters 10 (23), 5425-5428, 2008 | 59 | 2008 |
| EZH2 inhibition in multiple myeloma downregulates myeloma associated oncogenes and upregulates microRNAs with potential tumor suppressor functions M Alzrigat, AA Párraga, P Agarwal, H Zureigat, A Österborg, H Nahi, A Ma, ... Oncotarget 8 (6), 10213, 2017 | 57 | 2017 |
| Structure–activity relationship studies for enhancer of zeste homologue 2 (EZH2) and enhancer of zeste homologue 1 (EZH1) inhibitors X Yang, F Li, KD Konze, J Meslamani, A Ma, PJ Brown, MM Zhou, ... Journal of medicinal chemistry 59 (16), 7617-7633, 2016 | 55 | 2016 |
| An oral selective alpha-1A adrenergic receptor agonist prevents doxorubicin cardiotoxicity JY Beak, W Huang, JS Parker, ST Hicks, C Patterson, PC Simpson, A Ma, ... Basic to Translational Science 2 (1), 39-53, 2017 | 51 | 2017 |
| EZH2 inhibition enhances the efficacy of an EGFR inhibitor in suppressing colon cancer cells BW Katona, Y Liu, A Ma, J Jin, X Hua Cancer biology & therapy 15 (12), 1677-1687, 2014 | 50 | 2014 |
| The dynamic conformational landscape of the protein methyltransferase SETD8 S Chen, RP Wiewiora, F Meng, N Babault, A Ma, W Yu, K Qian, H Hu, ... Elife 8, e45403, 2019 | 42 | 2019 |
