John Tesmer
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Crystal structure of the catalytic domains of adenylyl cyclase in a complex with Gs GTPS
JJG Tesmer, RK Sunahara, AG Gilman, SR Sprang
Science 278 (5345), 1907-1916, 1997
Structure of RGS4 bound to AlF4−-activated Gi1: stabilization of the transition state for GTP hydrolysis
JJG Tesmer, DM Berman, AG Gilman, SR Sprang
Cell 89 (2), 251-261, 1997
Keeping G proteins at bay: A complex between G protein-coupled receptor kinase 2 and Gß
DT Lodowski, JA Pitcher, WD Capel, RJ Lefkowitz, JJG Tesmer
Science 300 (5623), 1256-1262, 2003
G protein-coupled receptor kinases: more than just kinases and not only for GPCRs
EV Gurevich, JJG Tesmer, A Mushegian, VV Gurevich
Pharmacology & therapeutics 133 (1), 40-69, 2012
Crystal structure of the adenylyl cyclase activator Gs
RK Sunahara, JJG Tesmer, AG Gilman, SR Sprang
Science 278 (5345), 1943-1947, 1997
Two-metal-ion catalysis in adenylyl cyclase
JJG Tesmer, RK Sunahara, RA Johnson, G Gosselin, AG Gilman, ...
Science 285 (5428), 756-760, 1999
Snapshot of activated G proteins at the membrane: the Gq-GRK2-Gß complex
VM Tesmer, T Kawano, A Shankaranarayanan, T Kozasa, JJG Tesmer
Science 310 (5754), 1686-1690, 2005
The crystal structure of GMP synthetase reveals a novel catalytic triad and is a structural paradigm for two enzyme families
JJG Tesmer, TJ Klem, ML Deras, VJ Davisson, JL Smith
Nature structural biology 3 (1), 74-86, 1996
Exchange of substrate and inhibitor specificities between adenylyl and guanylyl cyclases
RK Sunahara, A Beuve, JJG Tesmer, SR Sprang, DL Garbers, AG Gilman
Journal of Biological Chemistry 273 (26), 16332-16338, 1998
Structure of Gq-p63RhoGEF-RhoA complex reveals a pathway for the activation of RhoA by GPCRs
S Lutz, A Shankaranarayanan, C Coco, M Ridilla, MR Nance, C Vettel, ...
Science 318 (5858), 1923-1927, 2007
Feedback inhibition of G protein-coupled receptor kinase 2 (GRK2) activity by extracellular signal-regulated kinases
JA Pitcher, JJG Tesmer, JLR Freeman, WD Capel, WC Stone, ...
Journal of Biological Chemistry 274 (49), 34531-34534, 1999
Monomeric rhodopsin is sufficient for normal rhodopsin kinase (GRK1) phosphorylation and arrestin-1 binding
TH Bayburt, SA Vishnivetskiy, MA McLean, T Morizumi, C Huang, ...
Journal of Biological Chemistry 286 (2), 1420-1428, 2011
Identification of a Gi binding site on type V adenylyl cyclase
CW Dessauer, JJG Tesmer, SR Sprang, AG Gilman
Journal of Biological Chemistry 273 (40), 25831-25839, 1998
Structural determinants of RhoA binding and nucleotide exchange in leukemia-associated Rho guanine-nucleotide exchange factor
R Kristelly, G Gao, JJG Tesmer
Journal of Biological Chemistry 279 (45), 47352-47362, 2004
Structure and function of heterotrimeric G protein-regulated Rho guanine nucleotide exchange factors
M Aittaleb, CA Boguth, JJG Tesmer
Molecular pharmacology 77 (2), 111-125, 2010
Paroxetine is a direct inhibitor of g protein-coupled receptor kinase 2 and increases myocardial contractility
DM Thal, KT Homan, J Chen, EK Wu, PM Hinkle, ZM Huang, JK Chuprun, ...
ACS chemical biology 7 (11), 1830-1839, 2012
The structure, catalytic mechanism and regulation of adenylyl cyclase
JJG Tesmer, SR Sprang
Current opinion in structural biology 8 (6), 713-719, 1998
Molecular Basis for P-Site Inhibition of Adenylyl Cyclase,
JJG Tesmer, CW Dessauer, RK Sunahara, LD Murray, RA Johnson, ...
Biochemistry 39 (47), 14464-14471, 2000
G protein-coupled receptor kinase 2/Gq/11 interaction: a novel surface on a regulator of G protein signaling homology domain for binding G subunits
R Sterne-Marr, JJG Tesmer, PW Day, RAP Stracquatanio, JAE Cilente, ...
Journal of Biological Chemistry 278 (8), 6050-6058, 2003
Self-masking in an intact ERM-merlin protein: an active role for the central -helical domain
Q Li, MR Nance, R Kulikauskas, K Nyberg, R Fehon, PA Karplus, ...
Journal of molecular biology 365 (5), 1446-1459, 2007
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