A translational platform PBPK model for antibody disposition in the brain HY Chang, S Wu, G Meno-Tetang, DK Shah Journal of pharmacokinetics and pharmacodynamics 46, 319-338, 2019 | 54 | 2019 |
Current progress and limitations of AAV mediated delivery of protein therapeutic genes and the importance of developing quantitative pharmacokinetic/pharmacodynamic (PK/PD) models EA Chowdhury, G Meno-Tetang, HY Chang, S Wu, HW Huang, T Jamier, ... Advanced Drug Delivery Reviews 170, 214-237, 2021 | 48 | 2021 |
Brain pharmacokinetics of anti-transferrin receptor antibody affinity variants in rats determined using microdialysis HY Chang, S Wu, Y Li, W Zhang, M Burrell, CI Webster, DK Shah MAbs 13 (1), 1874121, 2021 | 26 | 2021 |
Determination of ADC cytotoxicity in immortalized human cell lines S Wu, DK Shah Antibody-Drug Conjugates: Methods and Protocols, 329-340, 2020 | 10 | 2020 |
Effect of the size of protein therapeutics on brain pharmacokinetics following systematic administration HY Chang, S Wu, Y Li, L Guo, Y Li, DK Shah The AAPS journal 24 (3), 62, 2022 | 9 | 2022 |
Towards a translational physiologically-based pharmacokinetic (PBPK) model for receptor-mediated transcytosis of anti-transferrin receptor monoclonal antibodies in the central … HY Chang, S Wu, EA Chowdhury, DK Shah Journal of Pharmacokinetics and Pharmacodynamics 49 (3), 337-362, 2022 | 8 | 2022 |
Assessment of AAV9 distribution and transduction in rats after administration through Intrastriatal, Intracisterna magna and Lumbar Intrathecal routes J Chandran, EA Chowdhury, M Perkinton, T Jamier, D Sutton, S Wu, ... Gene Therapy 30 (1), 132-141, 2023 | 4 | 2023 |
PBPK model for antibody disposition in mouse brain: validation using large-pore microdialysis data S Wu, F Le Prieult, CJ Phipps, M Mezler, DK Shah Journal of Pharmacokinetics and Pharmacodynamics 49 (6), 579-592, 2022 | 4 | 2022 |
Algorithmic multiscale analysis for the FcRn mediated regulation of antibody PK in human DG Patsatzis, S Wu, DK Shah, DA Goussis Scientific Reports 12 (1), 6208, 2022 | 2 | 2022 |
Pharmacokinetics of AAV9 Mediated Trastuzumab Expression in Rat Brain Following Systemic and Local Administration EA Chowdhury, M Ahuja, S Wu, S Liu, HW Huang, M Kumar, KS Sunkara, ... Journal of Pharmaceutical Sciences 113 (1), 131-140, 2024 | 1 | 2024 |
Investigation of Antibody Pharmacokinetics in the Brain Following Intra-CNS Administration and Development of PBPK Model to Characterize the Data S Wu, HY Chang, EA Chowdhury, HW Huang, DK Shah The AAPS Journal 26 (2), 29, 2024 | | 2024 |
Expansion of platform physiologically-based pharmacokinetic model for monoclonal antibodies towards different preclinical species: cats, sheep, and dogs HW Huang, S Wu, EA Chowdhury, DK Shah Journal of Pharmacokinetics and Pharmacodynamics, 1-18, 2023 | | 2023 |