| Silicon-Based Metalloprotease Inhibitors: Synthesis and Evaluation of Silanol and Silanediol Peptide Analogues as Inhibitors of Angiotensin-Converting Enzyme1 M Mutahi, T Nittoli, L Guo, SMN Sieburth Journal of the American Chemical Society 124 (25), 7363-7375, 2002 | 173 | 2002 |
| Silanediols: a new class of potent protease inhibitors SMN Sieburth, T Nittoli, AM Mutahi, L Guo Angewandte Chemie International Edition 37 (6), 812-814, 1998 | 133 | 1998 |
| Silanol reactivity: evaluation of silanolate as a metalation-directing group SM Sieburth, L Fensterbank The Journal of Organic Chemistry 58 (23), 6314-6318, 1993 | 128* | 1993 |
| Intramolecular reactions of temporarily silicon-tethered molecules L Fensterbank, M Malacria, SMN Sieburth Synthesis 1997 (08), 813-854, 1997 | 115 | 1997 |
| The [4+ 4] cycloaddition and its strategic application in natural product synthesis SMN Sieburth, NT Cunard Tetrahedron 52 (18), 6251-6282, 1996 | 113 | 1996 |
| Macroexpansion methodology: Medium ring synthesis based on an eight unit ring expansion process PA Wender, SMN Sieburth, JJ Petraitis, SK Singh Tetrahedron 37 (23), 3967-3975, 1981 | 103* | 1981 |
| Drug design with a new transition state analog of the hydrated carbonyl: silicon-based inhibitors of the HIV protease CA Chen, SMN Sieburth, A Glekas, GW Hewitt, GL Trainor, ... Chemistry & biology 8 (12), 1161-1166, 2001 | 101 | 2001 |
| Silanediol protease inhibitors: From conception to validation SMN Sieburth, CA Chen European journal of organic chemistry 2006 (2), 311-322, 2006 | 90 | 2006 |
| Silanol synthesis: reaction of hexaphenylcyclotrisiloxane with organometallic reagents SM Sieburth, W Mu The Journal of Organic Chemistry 58 (26), 7584-7586, 1993 | 70 | 1993 |
| Silanediol Inhibitors of Angiotensin-Converting Enzyme. Synthesis and Evaluation of Four Diastereomers of Phe[Si]Ala Dipeptide Analogues1 J Kim, G Hewitt, P Carroll, SMN Sieburth The Journal of Organic Chemistry 70 (15), 5781-5789, 2005 | 69 | 2005 |
| Structural Analysis of Silanediols as Transition-State-Analogue Inhibitors of the Benchmark Metalloprotease Thermolysin, DH Juers, J Kim, BW Matthews, SMN Sieburth Biochemistry 44 (50), 16524-16528, 2005 | 64 | 2005 |
| Practical method for. alpha.-alkenyl ketone synthesis based on a facile reductive rearrangement of alkynyl halohydrins PA Wender, DA Holt, SM Sieburth Journal of the American Chemical Society 105 (10), 3348-3350, 1983 | 62 | 1983 |
| A Silanediol Inhibitor of the Metalloprotease Thermolysin: Synthesis and Comparison with a Phosphinic Acid Inhibitor1 J Kim, SMN Sieburth The Journal of Organic Chemistry 69 (9), 3008-3014, 2004 | 59 | 2004 |
| Silanediol-based inhibitor of thermolysin J Kim, A Glekas, SMN Sieburth Bioorganic & medicinal chemistry letters 12 (24), 3625-3627, 2002 | 58 | 2002 |
| Enantioselective α-Silyl Amino Acid Synthesis by Reverse-Aza-Brook Rearrangement G Liu, SMN Sieburth Organic Letters 5 (24), 4677-4679, 2003 | 53 | 2003 |
| A photochemical [4+ 4] method for the construction of annulated eight-membered rings SMN Sieburth, JL Chen Journal of the American Chemical Society 113 (21), 8163-8164, 1991 | 53 | 1991 |
| Efficient, enantioselective assembly of silanediol protease inhibitors Y Bo, S Singh, HQ Duong, C Cao, SMN Sieburth Organic letters 13 (7), 1787-1789, 2011 | 52 | 2011 |
| Serine protease inhibition by a silanediol peptidomimetic S Singh, SMN Sieburth Organic letters 14 (17), 4422-4425, 2012 | 50 | 2012 |
| Asymmetric Synthesis of α-Amino Allyl, Benzyl, and Propargyl Silanes by Metalation and Rearrangement SMN Sieburth, HK O'Hare, J Xu, Y Chen, G Liu Organic Letters 5 (11), 1859-1861, 2003 | 44 | 2003 |
| Fusicoccin ring system by [4+ 4] cycloaddition. Control of diastereoselectivity through hydrogen bonding SM Sieburth, KF McGee Jr, TH Al-Tel Journal of the American Chemical Society 120 (3), 587-588, 1998 | 43 | 1998 |
