| The structured core domain of áB-crystallin can prevent amyloid fibrillation and associated toxicity GKA Hochberg, H Ecroyd, C Liu, D Cox, D Cascio, MR Sawaya, ... Proceedings of the National Academy of Sciences 111 (16), E1562-E1570, 2014 | 218 | 2014 |
| Small heat-shock proteins prevent á-synuclein aggregation via transient interactions and their efficacy is affected by the rate of aggregation D Cox, E Selig, MDW Griffin, JA Carver, H Ecroyd Journal of Biological Chemistry 291 (43), 22618-22629, 2016 | 122 | 2016 |
| The small heat shock protein Hsp27 binds á-synuclein fibrils, preventing elongation and cytotoxicity D Cox, DR Whiten, JWP Brown, MH Horrocks, R San Gil, CM Dobson, ... Journal of Biological Chemistry 293 (12), 4486-4497, 2018 | 115 | 2018 |
| Preventing á-synuclein aggregation: the role of the small heat-shock molecular chaperone proteins D Cox, JA Carver, H Ecroyd Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease 1842 (9 …, 2014 | 112 | 2014 |
| Single-molecule characterization of the interactions between extracellular chaperones and toxic á-synuclein oligomers DR Whiten, D Cox, MH Horrocks, CG Taylor, S De, P Flagmeier, L Tosatto, ... Cell reports 23 (12), 3492-3500, 2018 | 64 | 2018 |
| The small heat shock proteins áB-crystallin (HSPB5) and Hsp27 (HSPB1) inhibit the intracellular aggregation of á-synuclein D Cox, H Ecroyd Cell Stress and Chaperones 22 (4), 589-600, 2017 | 59 | 2017 |
| How to assess prognostic models for survival data: a case study in oncology M Schumacher, E Graf, T Gerds Methods of information in medicine 42 (05), 564-571, 2003 | 57 | 2003 |
| Sequence grammar underlying the unfolding and phase separation of globular proteins KM Ruff, YH Choi, D Cox, AR Ormsby, Y Myung, DB Ascher, SE Radford, ... Molecular cell 82 (17), 3193-3208. e8, 2022 | 49 | 2022 |
| Widespread remodeling of proteome solubility in response to different protein homeostasis stresses X Sui, DEV Pires, AR Ormsby, D Cox, S Nie, G Vecchi, M Vendruscolo, ... Proceedings of the National Academy of Sciences 117 (5), 2422-2431, 2020 | 49 | 2020 |
| Protein aggregation in cell biology: An aggregomics perspective of health and disease D Cox, C Raeburn, X Sui, DM Hatters Seminars in Cell & Developmental Biology 99, 40-54, 2020 | 46 | 2020 |
| A biosensor-based framework to measure latent proteostasis capacity RJ Wood, AR Ormsby, M Radwan, D Cox, A Sharma, T Vöpel, ... Nature communications 9 (1), 287, 2018 | 40 | 2018 |
| Arginine in C9ORF72 dipolypeptides mediates promiscuous proteome binding and multiple modes of toxicity M Radwan, CS Ang, AR Ormsby, D Cox, JC Daly, GE Reid, DM Hatters Molecular & Cellular Proteomics 19 (4), 640-654, 2020 | 31 | 2020 |
| N-and C-terminal regions of áB-crystallin and Hsp27 mediate inhibition of amyloid nucleation, fibril binding, and fibril disaggregation EE Selig, CO Zlatic, D Cox, YF Mok, PR Gooley, H Ecroyd, MDW Griffin Journal of Biological Chemistry 295 (29), 9838-9854, 2020 | 26 | 2020 |
| Neurodegenerative disease-associated protein aggregates are poor inducers of the heat shock response in neuronal cells R San Gil, D Cox, L McAlary, T Berg, AK Walker, JJ Yerbury, L Ooi, ... Journal of cell science 133 (15), jcs243709, 2020 | 10 | 2020 |
| Deletion of the Plasmodium falciparum exported protein PTP7 leads to Maurer¢s clefts vesiculation, host cell remodeling defects, and loss of surface presentation of … OMS Carmo, GJ Shami, D Cox, B Liu, AJ Blanch, S Tiash, L Tilley, ... Plos Pathogens 18 (8), e1009882, 2022 | 9 | 2022 |
| Hidden information on protein function in censuses of proteome foldedness D Cox, CS Ang, NB Nillegoda, GE Reid, DM Hatters Nature communications 13 (1), 1992, 2022 | 9 | 2022 |
| Nascent mutant Huntingtin exon 1 chains do not stall on ribosomes during translation but aggregates do recruit machinery involved in ribosome quality control and RNA AR Ormsby, D Cox, J Daly, D Priest, E Hinde, DM Hatters PloS one 15 (7), e0233583, 2020 | 6 | 2020 |
| PINK1 signalling in neurodegenerative disease DR Whiten, D Cox, CM Sue Essays in Biochemistry 65 (7), 913-923, 2021 | 5 | 2021 |
| Replicative aging impedes stress-induced assembly of a key human protein disaggregase Y Mathangasinghe, N Alberts, C Rosado, D Cox, N Payne, AR Ormsby, ... | 3 | 2023 |
| A biosensor of protein foldedness identifies increased “holdase” activity of chaperones in the nucleus following increased cytosolic protein aggregation CB Raeburn, AR Ormsby, D Cox, CA Gerak, C Makhoul, NS Moily, ... Journal of Biological Chemistry 298 (8), 2022 | 3 | 2022 |
