Dimitris Kletsas
Dimitris Kletsas
Research Director, NCSR "Demokritos"
Verified email at
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Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions
VG Gorgoulis, LVF Vassiliou, P Karakaidos, P Zacharatos, A Kotsinas, ...
Nature 434 (7035), 907-913, 2005
Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints
J Bartkova, N Rezaei, M Liontos, P Karakaidos, D Kletsas, N Issaeva, ...
Nature 444 (7119), 633-637, 2006
Molecular mechanisms of biological aging in intervertebral discs
NV Vo, RA Hartman, PR Patil, MV Risbud, D Kletsas, JC Iatridis, ...
Journal of orthopaedic research 34 (8), 1289-1306, 2016
Specific lipofuscin staining as a novel biomarker to detect replicative and stress-induced senescence. A method applicable in cryo-preserved and archival tissues
EA Georgakopoulou, K Tsimaratou, K Evangelou, MPJ Fernandez, ...
Aging (Albany NY) 5 (1), 37, 2013
Senescence in human intervertebral discs
S Roberts, EH Evans, D Kletsas, DC Jaffray, SM Eisenstein
European Spine Journal 15, 312-316, 2006
The bone-specific transcriptional regulator Cbfa1 is a target of mechanical signals in osteoblastic cells
PG Ziros, APR Gil, T Georgakopoulos, I Habeos, D Kletsas, EK Basdra, ...
Journal of Biological Chemistry 277 (26), 23934-23941, 2002
Human fibroblast alterations induced by low power laser irradiation at the single cell level using confocal microscopy
E Alexandratou, D Yova, P Handris, D Kletsas, S Loukas
Photochemical & Photobiological Sciences 1, 547-552, 2002
Chronic p53-independent p21 expression causes genomic instability by deregulating replication licensing
P Galanos, K Vougas, D Walter, A Polyzos, A Maya-Mendoza, ...
Nature cell biology 18 (7), 777-789, 2016
Oxidative stress inhibits the proliferation, induces premature senescence and promotes a catabolic phenotype in human nucleus pulposus intervertebral disc cells
A Dimozi, E Mavrogonatou, A Sklirou, D Kletsas
Eur Cell Mater 30 (89), 102, 2015
Inflammatory and catabolic signalling in intervertebral discs: the roles of NF-κB and MAP kinases
K Wuertz, N Vo, D Kletsas, N Boos
European Cells and Materials 23, 103-119; discussion 119, 2012
Deregulated overexpression of hCdt1 and hCdc6 promotes malignant behavior
M Liontos, M Koutsami, M Sideridou, K Evangelou, D Kletsas, B Levy, ...
Cancer research 67 (22), 10899-10909, 2007
Robust, universal biomarker assay to detect senescent cells in biological specimens
K Evangelou, N Lougiakis, SV Rizou, A Kotsinas, D Kletsas, ...
Aging cell 16 (1), 192-197, 2017
Bioactive non-coloured polyphenols content of grapes, wines and vinification by-products: Evaluation of the antioxidant activities of their extracts
M Anastasiadi, H Pratsinis, D Kletsas, AL Skaltsounis, SA Haroutounian
Food research international 43 (3), 805-813, 2010
Resveratrol and related stilbenes: their anti-aging and anti-angiogenic properties
KM Kasiotis, H Pratsinis, D Kletsas, SA Haroutounian
Food and Chemical Toxicology 61, 112-120, 2013
PDGF, bFGF and IGF-I stimulate the proliferation of intervertebral disc cells in vitro via the activation of the ERK and Akt signaling pathways
H Pratsinis, D Kletsas
European Spine Journal 16, 1858-1866, 2007
Characterization and cytotoxicity of ions released from stainless steel and nickel-titanium orthodontic alloys
T Eliades, H Pratsinis, D Kletsas, G Eliades, M Makou
American Journal of Orthodontics and Dentofacial Orthopedics 125 (1), 24-29, 2004
Mechanical loading of the intervertebral disc: from the macroscopic to the cellular level
C Neidlinger-Wilke, F Galbusera, H Pratsinis, E Mavrogonatou, A Mietsch, ...
European Spine Journal 23, 333-343, 2014
Intracellular clusterin inhibits mitochondrial apoptosis by suppressing p53-activating stress signals and stabilizing the cytosolic Ku70-Bax protein complex
IP Trougakos, M Lourda, MH Antonelou, D Kletsas, VG Gorgoulis, ...
Clinical cancer research 15 (1), 48-59, 2009
Transcription factor E2F‐1 acts as a growth‐promoting factor and is associated with adverse prognosis in non‐small cell lung carcinomas
VG Gorgoulis, P Zacharatos, G Mariatos, A Kotsinas, M Bouda, D Kletsas, ...
The Journal of pathology 198 (2), 142-156, 2002
Grape stem extracts: Polyphenolic content and assessment of their in vitro antioxidant properties
M Anastasiadi, H Pratsinis, D Kletsas, AL Skaltsounis, SA Haroutounian
LWT-Food Science and Technology 48 (2), 316-322, 2012
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