| Identifying drug effects via pathway alterations using an integer linear programming optimization formulation on phosphoproteomic data A Mitsos, IN Melas, P Siminelakis, AD Chairakaki, J Saez-Rodriguez, ... PLoS computational biology 5 (12), e1000591, 2009 | 155 | 2009 |
| Identifying drug effects via pathway alterations using an integer linear programming optimization formulation on phosphoproteomic data A Mitsos, IN Melas, P Siminelakis, AD Chairakaki, J Saez-Rodriguez, ... PLoS computational biology 5 (12), e1000591, 2009 | 155 | 2009 |
| Rheumatoid arthritis patients display B-cell dysregulation already in the naïve repertoire consistent with defects in B-cell tolerance Y Wang, KA Lloyd, I Melas, D Zhou, R Thyagarajan, J Lindqvist, ... Scientific reports 9 (1), 19995, 2019 | 73 | 2019 |
| The species translation challenge—a systems biology perspective on human and rat bronchial epithelial cells C Poussin, C Mathis, LG Alexopoulos, DE Messinis, RHJ Dulize, ... Scientific Data 1 (1), 1-14, 2014 | 51 | 2014 |
| Identification of drug-specific pathways based on gene expression data: application to drug induced lung injury IN Melas, T Sakellaropoulos, F Iorio, LG Alexopoulos, WY Loh, ... Integrative biology 7 (8), 904-920, 2015 | 49 | 2015 |
| Detecting and removing inconsistencies between experimental data and signaling network topologies using integer linear programming on interaction graphs IN Melas, R Samaga, LG Alexopoulos, S Klamt PLoS computational biology 9 (9), e1003204, 2013 | 46 | 2013 |
| Modeling of signaling pathways in chondrocytes based on phosphoproteomic and cytokine release data IN Melas, AD Chairakaki, EI Chatzopoulou, DE Messinis, T Katopodi, ... Osteoarthritis and Cartilage 22 (3), 509-518, 2014 | 40 | 2014 |
| Phosphoproteomics in drug discovery MK Morris, A Chi, IN Melas, LG Alexopoulos Drug discovery today 19 (4), 425-432, 2014 | 36 | 2014 |
| Combined logical and data-driven models for linking signalling pathways to cellular response IN Melas, A Mitsos, DE Messinis, TS Weiss, LG Alexopoulos BMC systems biology 5, 1-12, 2011 | 34 | 2011 |
| Signaling networks in MS: a systems-based approach to developing new pharmacological therapies E Kotelnikova, M Bernardo-Faura, G Silberberg, NA Kiani, D Messinis, ... Multiple Sclerosis Journal 21 (2), 138-146, 2015 | 30 | 2015 |
| Non Linear Programming (NLP) formulation for quantitative modeling of protein signal transduction pathways A Mitsos, IN Melas, MK Morris, J Saez-Rodriguez, DA Lauffenburger, ... PLoS One 7 (11), e50085, 2012 | 21 | 2012 |
| Construction of large signaling pathways using an adaptive perturbation approach with phosphoproteomic data IN Melas, A Mitsos, DE Messinis, TS Weiss, JS Rodriguez, ... Molecular Biosystems 8 (5), 1571-1584, 2012 | 16 | 2012 |
| Translational systems pharmacology‐based predictive assessment of drug‐induced cardiomyopathy DE Messinis, IN Melas, J Hur, N Varshney, LG Alexopoulos, JPF Bai CPT: Pharmacometrics & Systems Pharmacology 7 (3), 166-174, 2018 | 14 | 2018 |
| A crowd-sourcing approach for the construction of species-specific cell signaling networks E Bilal, T Sakellaropoulos, C Participants, IN Melas, DE Messinis, ... Bioinformatics 31 (4), 484-491, 2014 | 13 | 2014 |
| Construction of Cell Type-Specific Logic Models of Signaling Networks Using CellNOpt MK Morris, I Melas, J Saez-Rodriguez Computational Toxicology: Volume II, 179-214, 2013 | 13 | 2013 |
| Advances in omics for informed pharmaceutical research and development in the era of systems medicine JPF Bai, IN Melas, J Hur, E Guo Expert opinion on drug discovery 13 (1), 1-4, 2018 | 10 | 2018 |
| Leveraging systems biology approaches in clinical pharmacology IN Melas, K Kretsos, LG Alexopoulos Biopharmaceutics & drug disposition 34 (9), 477-488, 2013 | 8 | 2013 |
| Construction of signaling pathways and identification of drug effects on the liver cancer cell HepG2 LG Alexopoulos, IN Melas, AD Chairakaki, J Saez-Rodriguez, A Mitsos 2010 Annual International Conference of the IEEE Engineering in Medicine and …, 2010 | 8 | 2010 |
| Identification of drug-specific pathways based on gene expression data: application to drug induced lung injury. Integr Biol IN Melas, T Sakellaropoulos, F Iorio, LG Alexopoulos, WY Loh, ... Royal Society of Chemistry, 2015 | 7 | 2015 |
| Network‐based analysis of nutraceuticals in human hepatocellular carcinomas reveals mechanisms of chemopreventive action M Michailidou, IN Melas, DE Messinis, S Klamt, LG Alexopoulos, ... CPT: pharmacometrics & systems pharmacology 4 (6), 350-361, 2015 | 7 | 2015 |
