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James K Chen
James K Chen
Professor of Chemical and Systems Biology, Developmental Biology, and Chemistry; Stanford University
Verified email at stanford.edu - Homepage
Title
Cited by
Cited by
Year
Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened
JK Chen, J Taipale, MK Cooper, PA Beachy
Genes & development 16 (21), 2743-2748, 2002
17722002
Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine
J Taipale, JK Chen, MK Cooper, B Wang, RK Mann, L Milenkovic, ...
Nature 406 (6799), 1005-1009, 2000
15882000
Structural basis for the binding of proline-rich peptides to SH3 domains
H Yu, JK Chen, S Feng, DC Dalgarno, AW Brauer, SL Schrelber
Cell 76 (5), 933-945, 1994
13301994
Small molecule modulation of Smoothened activity
JK Chen, J Taipale, KE Young, T Maiti, PA Beachy
Proceedings of the National Academy of Sciences 99 (22), 14071-14076, 2002
11392002
Two binding orientations for peptides to the Src SH3 domain: development of a general model for SH3-ligand interactions
S Feng, JK Chen, H Yu, JA Simon, SL Schreiber
Science 266 (5188), 1241-1247, 1994
10891994
Medulloblastoma growth inhibition by hedgehog pathway blockade
DM Berman, SS Karhadkar, AR Hallahan, JI Pritchard, CG Eberhart, ...
Science 297 (5586), 1559-1561, 2002
10342002
Stromal response to Hedgehog signaling restrains pancreatic cancer progression
JJ Lee, RM Perera, H Wang, DC Wu, XS Liu, S Han, J Fitamant, PD Jones, ...
Proceedings of the National Academy of Sciences 111 (30), E3091-E3100, 2014
5072014
Purmorphamine activates the Hedgehog pathway by targeting Smoothened
S Sinha, JK Chen
Nature chemical biology 2 (1), 29-30, 2006
4502006
Small-molecule inhibitors of the AAA+ ATPase motor cytoplasmic dynein
AJ Firestone, JS Weinger, M Maldonado, K Barlan, LD Langston, ...
Nature 484 (7392), 125-129, 2012
3962012
The BAH domain of ORC1 links H4K20me2 to DNA replication licensing and Meier–Gorlin syndrome
AJ Kuo, J Song, P Cheung, S Ishibe-Murakami, S Yamazoe, JK Chen, ...
Nature 484 (7392), 115-119, 2012
3762012
Organic wastewater treatment by a single-atom catalyst and electrolytically produced H 2 O 2
J Xu, X Zheng, Z Feng, Z Lu, Z Zhang, W Huang, Y Li, D Vuckovic, Y Li, ...
Nature Sustainability 4 (3), 233-241, 2021
3722021
A small molecule that binds Hedgehog and blocks its signaling in human cells
BZ Stanton, LF Peng, N Maloof, K Nakai, X Wang, JL Duffner, KM Taveras, ...
Nature chemical biology 5 (3), 154-156, 2009
3662009
Small-molecule inhibitors reveal multiple strategies for Hedgehog pathway blockade
JM Hyman, AJ Firestone, VM Heine, Y Zhao, CA Ocasio, K Han, M Sun, ...
Proceedings of the National Academy of Sciences 106 (33), 14132-14137, 2009
3532009
Activity-dependent internalization of smoothened mediated by ß-arrestin 2 and GRK2
W Chen, XR Ren, CD Nelson, LS Barak, JK Chen, PA Beachy, ...
Science 306 (5705), 2257-2260, 2004
3482004
A crucial requirement for Hedgehog signaling in small cell lung cancer
KS Park, LG Martelotto, M Peifer, ML Sos, AN Karnezis, MR Mahjoub, ...
Nature medicine 17 (11), 1504-1508, 2011
2832011
Light-controlled gene silencing in zebrafish embryos
IA Shestopalov, S Sinha, JK Chen
Nature chemical biology 3 (10), 650-651, 2007
2482007
An inducible long noncoding RNA amplifies DNA damage signaling
AM Schmitt, JT Garcia, T Hung, RA Flynn, Y Shen, K Qu, AY Payumo, ...
Nature genetics 48 (11), 1370-1376, 2016
2402016
Biased combinatorial libraries: novel ligands for the SH3 domain of phosphatidylinositol 3-kinase
JK Chen, WS Lane, AW Brauer, A Tanaka, SL Schreiber
Journal of the American Chemical Society 115 (26), 12591-12592, 1993
1901993
General method for regulating protein stability with light
KM Bonger, R Rakhit, AY Payumo, JK Chen, TJ Wandless
ACS chemical biology 9 (1), 111-115, 2014
1582014
Smoothened signal transduction is promoted by G protein-coupled receptor kinase 2
AR Meloni, GB Fralish, P Kelly, A Salahpour, JK Chen, RJ Wechsler-Reya, ...
Molecular and cellular biology 26 (20), 7550-7560, 2006
1522006
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