|Role for NLRP3 inflammasome–mediated, IL-1‚–dependent responses in severe, steroid-resistant asthma|
RY Kim, JW Pinkerton, AT Essilfie, AAB Robertson, KJ Baines, AC Brown, ...
American journal of respiratory and critical care medicine 196 (3), 283-297, 2017
|A GABAergic system in airway epithelium is essential for mucus overproduction in asthma|
YY Xiang, S Wang, M Liu, JA Hirota, J Li, W Ju, Y Fan, MM Kelly, B Ye, ...
Nature medicine 13 (7), 862-867, 2007
|Type 2 cytokines in the pathogenesis of sustained airway dysfunction and airway remodeling in mice|
R Leigh, R Ellis, JN Wattie, JA Hirota, KI Matthaei, PS Foster, PM O'Byrne, ...
American journal of respiratory and critical care medicine 169 (7), 860-867, 2004
|Group 2 innate lymphoid cells facilitate sensitization to local, but not systemic, TH2-inducing allergen exposures|
MJ Gold, F Antignano, TYF Halim, JA Hirota, MR Blanchet, C Zaph, ...
Journal of Allergy and Clinical Immunology 133 (4), 1142-1148. e5, 2014
|The airway epithelium nucleotide-binding domain and leucine-rich repeat protein 3 inflammasome is activated by urban particulate matter|
JA Hirota, SA Hirota, SM Warner, D Stefanowicz, F Shaheen, PL Beck, ...
Journal of Allergy and Clinical Immunology 129 (4), 1116-1125. e6, 2012
|Gene expression and in situ protein profiling of candidate SARS-CoV-2 receptors in human airway epithelial cells and lung tissue|
JA Aguiar, BJM Tremblay, MJ Mansfield, O Woody, B Lobb, A Banerjee, ...
European Respiratory Journal 56 (3), 2020
|Inflammasomes in the lung|
JW Pinkerton, RY Kim, AAB Robertson, JA Hirota, LG Wood, DA Knight, ...
Molecular immunology 86, 44-55, 2017
|Animal models of COPD: W hat do they tell us?|
B Jones, C Donovan, G Liu, HM Gomez, V Chimankar, CL Harrison, ...
Respirology 22 (1), 21-32, 2017
|Increased eosinophil-lineage committed progenitors in the lung of allergen-challenged mice|
DS Southam, N Widmer, R Ellis, JA Hirota, MD Inman, R Sehmi
Journal of Allergy and Clinical Immunology 115 (1), 95-102, 2005
|Mechanisms and treatments for severe, steroid‐resistant allergic airway disease and asthma|
PM Hansbro, RY Kim, MR Starkey, C Donovan, K Dua, JR Mayall, G Liu, ...
Immunological reviews 278 (1), 41-62, 2017
|Diesel exhaust augments allergen-induced lower airway inflammation in allergic individuals: a controlled human exposure study|
C Carlsten, A Blomberg, M Pui, T Sandstrom, SW Wong, N Alexis, J Hirota
Thorax 71 (1), 35-44, 2016
|Airway smooth muscle in asthma: phenotype plasticity and function|
JA Hirota, TTB Nguyen, D Schaafsma, P Sharma, T Tran
Pulmonary pharmacology & therapeutics 22 (5), 370-378, 2009
|Isolation, sequence, infectivity, and replication kinetics of severe acute respiratory syndrome coronavirus 2|
A Banerjee, JA Nasir, P Budylowski, L Yip, P Aftanas, N Christie, ...
Emerging infectious diseases 26 (9), 2054, 2020
|The nucleotide-binding domain, leucine-rich repeat protein 3 inflammasome/IL-1 receptor I axis mediates innate, but not adaptive, immune responses after exposure to particulate†…|
JA Hirota, MJ Gold, PR Hiebert, LG Parkinson, T Wee, D Smith, ...
American journal of respiratory cell and molecular biology 52 (1), 96-105, 2015
|Gob-5 is not essential for mucus overproduction in preclinical murine models of allergic asthma|
A Robichaud, SA Tuck, S Kargman, J Tam, E Wong, M Abramovitz, ...
American journal of respiratory cell and molecular biology 33 (3), 303-314, 2005
|Controlled diesel exhaust and allergen coexposure modulates microRNA and gene expression in humans: effects on inflammatory lung markers|
CF Rider, M Yamamoto, OP Günther, JA Hirota, A Singh, SJ Tebbutt, ...
Journal of Allergy and Clinical Immunology 138 (6), 1690-1700, 2016
|Mucosal production of uric acid by airway epithelial cells contributes to particulate matter-induced allergic sensitization|
MJ Gold, PR Hiebert, HY Park, D Stefanowicz, A Le, MR Starkey, A Deane, ...
Mucosal immunology 9 (3), 809-820, 2016
|Animal models of airway inflammation and airway smooth muscle remodelling in asthma|
JE Allen, RJ Bischof, HYS Chang, JA Hirota, SJ Hirst, MD Inman, ...
Pulmonary pharmacology & therapeutics 22 (5), 455-465, 2009
|Phenotypic profiling of CFTR modulators in patient-derived respiratory epithelia|
S Ahmadi, Z Bozoky, M Di Paola, S Xia, C Li, AP Wong, L Wellhauser, ...
NPJ genomic medicine 2 (1), 1-10, 2017
|Human airway epithelial cell innate immunity: relevance to asthma|
JA Hirota, DA Knight
Current opinion in immunology 24 (6), 740-746, 2012