Intercellular propagated misfolding of wild-type Cu/Zn superoxide dismutase occurs via exosome-dependent and-independent mechanisms LI Grad, JJ Yerbury, BJ Turner, WC Guest, E Pokrishevsky, MA O˘Neill, ... Proceedings of the National Academy of Sciences 111 (9), 3620-3625, 2014 | 449 | 2014 |
ANS binding reveals common features of cytotoxic amyloid species B Bolognesi, JR Kumita, TP Barros, EK Esbjorner, LM Luheshi, ... ACS chemical biology 5 (8), 735-740, 2010 | 415 | 2010 |
The extracellular chaperone clusterin influences amyloid formation and toxicity by interacting with prefibrillar structures JJ Yerbury, S Poon, S Meehan, B Thompson, JR Kumita, CM Dobson, ... The FASEB Journal 21 (10), 2312-2322, 2007 | 360 | 2007 |
CCNF mutations in amyotrophic lateral sclerosis and frontotemporal dementia KL Williams, S Topp, S Yang, B Smith, JA Fifita, ST Warraich, KY Zhang, ... Nature communications 7, 11253, 2016 | 221 | 2016 |
Walking the tightrope: Proteostasis and neurodegenerative disease. JJ Yerbury, L Ooi, A Dillin, DN Saunders, DM Hatters, PM Beart, ... Journal of Neurochemistry 137 (4), 489-505, 2016 | 211 | 2016 |
Extracellular Chaperones and Proteostasis AR Wyatt, JJ Yerbury, H Ecroyd, MR Wilson Annual Review of Biochemistry 82 (1), 295-322, 2013 | 186 | 2013 |
Potential roles of abundant extracellular chaperones in the control of amyloid formation and toxicity MR Wilson, JJ Yerbury, S Poon Molecular BioSystems 4 (1), 42-52, 2008 | 182 | 2008 |
Quality control of protein folding in extracellular space JJ Yerbury, EM Stewart, AR Wyatt, MR Wilson EMBO reports 6 (12), 1131-1136, 2005 | 173 | 2005 |
The microglial NLRP3 inflammasome is activated by amyotrophic lateral sclerosis proteins V Deora, JD Lee, EA Albornoz, L McAlary, CJ Jagaraj, AAB Robertson, ... Glia 68 (2), 407-421, 2020 | 156 | 2020 |
Clusterin facilitates in vivo clearance of extracellular misfolded proteins AR Wyatt, JJ Yerbury, P Berghofer, I Greguric, A Katsifis, CM Dobson, ... Cellular and Molecular Life Sciences 68, 3919-3931, 2011 | 154 | 2011 |
Distinct partitioning of ALS associated TDP-43, FUS and SOD1 mutants into cellular inclusions NE Farrawell, IA Lambert-Smith, ST Warraich, IP Blair, DN Saunders, ... Scientific Reports 5, 13416, 2015 | 142 | 2015 |
Association of regulatory T-cell expansion with progression of amyotrophic lateral sclerosis: a study of humans and a transgenic mouse model RK Sheean, FC McKay, E Cretney, CR Bye, ND Perera, D Tomas, ... JAMA neurology 75 (6), 681-689, 2018 | 141 | 2018 |
Prion-like propagation of protein misfolding and aggregation in amyotrophic lateral sclerosis L McAlary, SS Plotkin, JJ Yerbury, NR Cashman Frontiers in molecular neuroscience 12, 262, 2019 | 133 | 2019 |
The acute phase protein haptoglobin is a mammalian extracellular chaperone with an action similar to clusterin JJ Yerbury, MS Rybchyn, SB Easterbrook-Smith, C Henriques, MR Wilson Biochemistry 44 (32), 10914-10925, 2005 | 133 | 2005 |
P2X7 receptor activation induces reactive oxygen species formation and cell death in murine EOC13 microglia R Bartlett, JJ Yerbury, R Sluyter Mediators of inflammation 2013, 271813, 2013 | 116 | 2013 |
Protease activation of á2-macroglobulin modulates a chaperone-like action with broad specificity K French, JJ Yerbury, MR Wilson Biochemistry 47 (4), 1176-1185, 2008 | 114 | 2008 |
Extracellular aggregated Cu/Zn superoxide dismutase activates microglia to give a cytotoxic phenotype K Roberts, R Zeineddine, L Corcoran, W Li, IL Campbell, JJ Yerbury Glia 61 (3), 409-419, 2013 | 113 | 2013 |
Disease Mechanisms in ALS: Misfolded SOD1 Transferred Through Exosome-Dependent and Exosome-Independent Pathways JM Silverman, SM Fernando, LI Grad, AF Hill, BJ Turner, JJ Yerbury, ... Cellular and Molecular Neurobiology 36 (3), 377-81, 2016 | 112 | 2016 |
Spinal motor neuron protein supersaturation patterns are associated with inclusion body formation in ALS P Ciryam, IA Lambert-Smith, DM Bean, R Freer, F Cid, GG Tartaglia, ... Proceedings of the National Academy of Sciences 114 (20), E3935–E3943, 2017 | 110 | 2017 |
á2-Macroglobulin and haptoglobin suppress amyloid formation by interacting with prefibrillar protein species JJ Yerbury, JR Kumita, S Meehan, CM Dobson, MR Wilson Journal of biological chemistry 284 (7), 4246-4254, 2009 | 106 | 2009 |