| Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1 DJ Klionsky, AK Abdel-Aziz, S Abdelfatah, M Abdellatif, A Abdoli, S Abel, ... autophagy 17 (1), 1-382, 2021 | 10664 | 2021 |
| Endoplasmic reticulum stress contributes to beta cell apoptosis in type 2 diabetes DR Laybutt, AM Preston, MC Åkerfeldt, JG Kench, AK Busch, AV Biankin, ... Diabetologia 50, 752-763, 2007 | 1023 | 2007 |
| Ceramide generation is sufficient to account for the inhibition of the insulin-stimulated PKB pathway in C2C12 skeletal muscle cells pretreated with palmitate C Schmitz-Peiffer, DL Craig, TJ Biden Journal of Biological Chemistry 274 (34), 24202-24210, 1999 | 739 | 1999 |
| Rapid mobilization of Ca2+ from rat insulinoma microsomes by inositol-1,4,5-trisphosphate M Prentki, TJ Biden, D Janjic, RF Irvine, MJ Berridge, CB Wollheim Nature 309 (5968), 562-564, 1984 | 455 | 1984 |
| Molecular cloning and characterization of PKC iota, an atypical isoform of protein kinase C derived from insulin-secreting cells. LA Selbie, C Schmitz-Peiffer, Y Sheng, TJ Biden Journal of Biological Chemistry 268 (32), 24296-24302, 1993 | 452 | 1993 |
| Alterations in the expression and cellular localization of protein kinase C isozymes ε and θ are associated with insulin resistance in skeletal muscle of the high-fat–fed rat C Schmitz-Peiffer, CL Browne, ND Oakes, A Watkinson, DJ Chisholm, ... Diabetes 46 (2), 169-178, 1997 | 428 | 1997 |
| Protein Kinase Cζ activation mediates glucagon-like peptide-1–induced pancreatic β-cell proliferation J Buteau, S Foisy, CJ Rhodes, L Carpenter, TJ Biden, M Prentki Diabetes 50 (10), 2237-2243, 2001 | 325 | 2001 |
| Guanine nucleotides induce Ca2+-independent insulin secretion from permeabilized RINm5F cells. L Vallar, TJ Biden, CB Wollheim Journal of Biological Chemistry 262 (11), 5049-5056, 1987 | 281 | 1987 |
| Structural subtypes of the dopamine D2 receptor are functionally distinct: expression of the cloned D2A and D2B subtypes in a heterologous cell line. G Hayes, TJ Biden, LA Selbie, J Shine Molecular Endocrinology 6 (6), 920-926, 1992 | 257 | 1992 |
| Lipotoxic endoplasmic reticulum stress, β cell failure, and type 2 diabetes mellitus TJ Biden, E Boslem, KY Chu, N Sue Trends in Endocrinology & Metabolism 25 (8), 389-398, 2014 | 238 | 2014 |
| Expression profiling of palmitate-and oleate-regulated genes provides novel insights into the effects of chronic lipid exposure on pancreatic β-cell function AK Busch, D Cordery, GS Denyer, TJ Biden Diabetes 51 (4), 977-987, 2002 | 236 | 2002 |
| Inositol 1,4,5-trisphosphate mobilizes intracellular Ca2+ from permeabilized insulin-secreting cells TJ Biden, M Prentki, RF Irvine, MJ Berridge, CB Wollheim Biochemical Journal 223 (2), 467-473, 1984 | 229 | 1984 |
| Ca2+ regulates the inositol tris/tetrakisphosphate pathway in intact and broken preparations of insulin-secreting RINm5F cells. TJ Biden, CB Wollheim Journal of Biological Chemistry 261 (26), 11931-11934, 1986 | 223 | 1986 |
| Ca2+-mediated generation of inositol 1, 4, 5-triphosphate and inositol 1, 3, 4, 5-tetrakisphosphate in pancreatic islets. Studies with K+, glucose, and carbamylcholine. TJ Biden, B Peter-Riesch, W Schlegel, CB Wollheim Journal of Biological Chemistry 262 (8), 3567-3571, 1987 | 205 | 1987 |
| Increased fatty acid desaturation and enhanced expression of stearoyl coenzyme A desaturase protects pancreatic β-cells from lipoapoptosis AK Busch, E Gurisik, DV Cordery, M Sudlow, GS Denyer, DR Laybutt, ... Diabetes 54 (10), 2917-2924, 2005 | 203 | 2005 |
| A role for protein phosphatase 2A–like activity, but not atypical protein kinase Cζ, in the inhibition of protein kinase B/Akt and glycogen synthesis by palmitate R Cazzolli, L Carpenter, TJ Biden, C Schmitz-Peiffer Diabetes 50 (10), 2210-2218, 2001 | 191 | 2001 |
| Second messenger function of inositol 1, 4, 5-trisphosphate. Early changes in inositol phosphates, cytosolic Ca2+, and insulin release in carbamylcholine-stimulated RINm5F cells. CB Wollheim, TJ Biden Journal of Biological Chemistry 261 (18), 8314-8319, 1986 | 188 | 1986 |
| Protein kinase C function in muscle, liver, and β-cells and its therapeutic implications for type 2 diabetes C Schmitz-Peiffer, TJ Biden Diabetes 57 (7), 1774, 2008 | 186 | 2008 |
| A lipidomic screen of palmitate-treated MIN6 β-cells links sphingolipid metabolites with endoplasmic reticulum (ER) stress and impaired protein trafficking E Boslem, G MacIntosh, AM Preston, C Bartley, AK Busch, M Fuller, ... Biochemical Journal 435 (1), 267-276, 2011 | 183 | 2011 |
| G protein-coupled receptor (GPR) 40-dependent potentiation of insulin secretion in mouse islets is mediated by protein kinase D1 M Ferdaoussi, V Bergeron, B Zarrouki, J Kolic, J Cantley, J Fielitz, ... Diabetologia 55, 2682-2692, 2012 | 177 | 2012 |
Scot J MatkovichPrincipal Research Scientist, Eli Lilly and CompanyVerified email at lilly.com
