| Bcl6 and Blimp-1 are reciprocal and antagonistic regulators of T follicular helper cell differentiation RJ Johnston, AC Poholek, D DiToro, I Yusuf, D Eto, B Barnett, AL Dent, ... Science 325 (5943), 1006, 2009 | 1830 | 2009 |
| The Immunoreceptor TIGIT Regulates Antitumor and Antiviral CD8+ T Cell Effector Function RJ Johnston, L Comps-Agrar, J Hackney, X Yu, M Huseni, Y Yang, S Park, ... Cancer Cell, 2014 | 1087 | 2014 |
| ICOS receptor instructs T follicular helper cell versus effector cell differentiation via induction of the transcriptional repressor Bcl6 YS Choi, R Kageyama, D Eto, TC Escobar, RJ Johnston, L Monticelli, ... Immunity 34 (6), 932-946, 2011 | 1071 | 2011 |
| Effectors and memories: Bcl-6 and Blimp-1 in T and B lymphocyte differentiation S Crotty, RJ Johnston, SP Schoenberger Nature immunology 11 (2), 114-120, 2010 | 652 | 2010 |
| STAT5 is a potent negative regulator of TFH cell differentiation RJ Johnston, YS Choi, JA Diamond, JA Yang, S Crotty Journal of Experimental Medicine 209 (2), 243-250, 2012 | 559 | 2012 |
| Germinal center T follicular helper cell IL-4 production is dependent on signaling lymphocytic activation molecule receptor (CD150) I Yusuf, R Kageyama, L Monticelli, RJ Johnston, D DiToro, K Hansen, ... The Journal of Immunology 185 (1), 190-202, 2010 | 500 | 2010 |
| Bcl6 Expressing Follicular Helper CD4 T Cells Are Fate Committed Early and Have the Capacity To Form Memory YS Choi, JA Yang, I Yusuf, RJ Johnston, J Greenbaum, B Peters, S Crotty The Journal of Immunology, 2013 | 272 | 2013 |
| VISTA is an acidic pH-selective ligand for PSGL-1 RJ Johnston, LJ Su, J Pinckney, D Critton, E Boyer, A Krishnakumar, ... Nature 574 (7779), 565-570, 2019 | 264 | 2019 |
| Preclinical development of ipilimumab and nivolumab combination immunotherapy: mouse tumor models, in vitro functional studies, and cynomolgus macaque toxicology MJ Selby, JJ Engelhardt, RJ Johnston, LS Lu, M Han, K Thudium, D Yao, ... PloS one 11 (9), e0161779, 2016 | 232 | 2016 |
| Selective CD4+ T Cell Help for Antibody Responses to a Large Viral Pathogen: Deterministic Linkage of Specificities A Sette, M Moutaftsi, J Moyron-Quiroz, MM McCausland, DH Davies, ... Immunity 28 (6), 847-858, 2008 | 213 | 2008 |
| In Vivo RNA Interference Screens Identify Regulators of Antiviral CD4+ and CD8+ T Cell Differentiation R Chen, S Bélanger, MA Frederick, B Li, RJ Johnston, N Xiao, YC Liu, ... Immunity 41 (2), 325-338, 2014 | 119 | 2014 |
| IL15 stimulation with TIGIT blockade reverses CD155-mediated NK-cell dysfunction in melanoma JM Chauvin, M Ka, O Pagliano, C Menna, Q Ding, R DeBlasio, C Sanders, ... Clinical Cancer Research 26 (20), 5520-5533, 2020 | 101 | 2020 |
| CD155 on tumor cells drives resistance to immunotherapy by inducing the degradation of the activating receptor CD226 in CD8+ T cells M Braun, AR Aguilera, A Sundarrajan, D Corvino, K Stannard, S Krumeich, ... Immunity 53 (4), 805-823. e15, 2020 | 95 | 2020 |
| Methods of treating cancer using PD-1 axis binding antagonists and TIGIT inhibitors J Grogan, RJ Johnston, B Irving, J Hackney, X Yu, D Eaton, K Bowles, ... US Patent App. 15/239,569, 2017 | 95 | 2017 |
| CD96 Is an Immune Checkpoint That Regulates CD8+ T-cell Antitumor Function D Mittal, A Lepletier, J Madore, AR Aguilera, K Stannard, SJ Blake, ... Cancer immunology research 7 (4), 559-571, 2019 | 90 | 2019 |
| A conserved intratumoral regulatory T cell signature identifies 4-1BB as a pan-cancer target ZT Freeman, TR Nirschl, DH Hovelson, RJ Johnston, JJ Engelhardt, ... The Journal of clinical investigation 130 (3), 1405-1416, 2020 | 78 | 2020 |
| The checkpoint inhibitor TIGIT limits anti-tumor and anti-viral CD8+ T cell responses RJ Johnston, X Yu, JL Grogan OncoImmunology, 2015 | 56 | 2015 |
| EBI2 is a negative regulator of type I interferons in plasmacytoid and myeloid dendritic cells EY Chiang, RJ Johnston, JL Grogan PloS one 8 (12), e83457, 2013 | 41 | 2013 |
| Anti-TIGIT antibodies and methods of use MH J Grogan, RJ Johnston, Y Wu, W Liang, P Lupardus, M Yadav, D Seshasayee US Patent App. 15/274,603, 2017 | 40* | 2017 |
| Cutting edge: T follicular helper cell differentiation is defective in the absence of Bcl6 BTB repressor domain function JP Nance, S Bélanger, RJ Johnston, T Takemori, S Crotty The Journal of Immunology 194 (12), 5599-5603, 2015 | 40 | 2015 |
Shane CrottyProfessor, La Jolla Institute for ImmunologyVerified email at lji.org
