Meir Glick
Meir Glick
Director, Structural Chemistry, Merck & Co
Verified email at
Cited by
Cited by
Stable, soluble T‐cell receptor molecules for crystallization and therapeutics
JM Boulter, M Glick, PT Todorov, E Baston, M Sami, P Rizkallah, ...
Protein engineering 16 (9), 707-711, 2003
Analysis of pharmacology data and the prediction of adverse drug reactions and off‐target effects from chemical structure
A Bender, J Scheiber, M Glick, JW Davies, K Azzaoui, J Hamon, L Urban, ...
ChemMedChem: Chemistry Enabling Drug Discovery 2 (6), 861-873, 2007
From in silico target prediction to multi-target drug design: Current databases, methods and applications
A Koutsoukas, B Simms, J Kirchmair, PJ Bond, AV Whitmore, S Zimmer, ...
Journal of proteomics 74 (12), 2554-2574, 2011
How similar are similarity searching methods? A principal component analysis of molecular descriptor space
A Bender, JL Jenkins, J Scheiber, SCK Sukuru, M Glick, JW Davies
Journal of chemical information and modeling 49 (1), 108-119, 2009
Prediction of biological targets for compounds using multiple-category Bayesian models trained on chemogenomics databases
Nidhi, M Glick, JW Davies, JL Jenkins
Journal of chemical information and modeling 46 (3), 1124-1133, 2006
Bridging chemical and biological space:“target fishing” using 2D and 3D molecular descriptors
JH Nettles, JL Jenkins, A Bender, Z Deng, JW Davies, M Glick
Journal of medicinal chemistry 49 (23), 6802-6810, 2006
Interaction between the CD8 coreceptor and major histocompatibility complex class I stabilizes T cell receptor-antigen complexes at the cell surface
L Wooldridge, HA van den Berg, M Glick, E Gostick, B Laugel, ...
Journal of Biological Chemistry 280 (30), 27491-27501, 2005
Mapping adverse drug reactions in chemical space
J Scheiber, JL Jenkins, SCK Sukuru, A Bender, D Mikhailov, M Milik, ...
Journal of medicinal chemistry 52 (9), 3103-3107, 2009
Gaining insight into off-target mediated effects of drug candidates with a comprehensive systems chemical biology analysis
J Scheiber, B Chen, M Milik, SCK Sukuru, A Bender, D Mikhailov, ...
Journal of chemical information and modeling 49 (2), 308-317, 2009
Rethinking molecular similarity: comparing compounds on the basis of biological activity
PM Petrone, B Simms, F Nigsch, E Lounkine, P Kutchukian, A Cornett, ...
ACS chemical biology 7 (8), 1399-1409, 2012
A 3D similarity method for scaffold hopping from known drugs or natural ligands to new chemotypes
JL Jenkins, M Glick, JW Davies
Journal of medicinal chemistry 47 (25), 6144-6159, 2004
Streamlining lead discovery by aligning in silico and high-throughput screening
JW Davies, M Glick, JL Jenkins
Current opinion in chemical biology 10 (4), 343-351, 2006
Dark chemical matter as a promising starting point for drug lead discovery
AM Wassermann, E Lounkine, D Hoepfner, G Le Goff, FJ King, C Studer, ...
Nature chemical biology 11 (12), 958-966, 2015
Enrichment of high-throughput screening data with increasing levels of noise using support vector machines, recursive partitioning, and laplacian-modified naive bayesian …
M Glick, JL Jenkins, JH Nettles, H Hitchings, JW Davies
Journal of chemical information and modeling 46 (1), 193-200, 2006
Identification of TNO155, an allosteric SHP2 inhibitor for the treatment of cancer
MJ LaMarche, M Acker, A Argintaru, D Bauer, J Boisclair, H Chan, ...
Journal of medicinal chemistry 63 (22), 13578-13594, 2020
Finding more needles in the haystack: A simple and efficient method for improving high-throughput docking results
AE Klon, M Glick, M Thoma, P Acklin, JW Davies
Journal of medicinal chemistry 47 (11), 2743-2749, 2004
“Bayes affinity fingerprints” improve retrieval rates in virtual screening and define orthogonal bioactivity space: when are multitarget drugs a feasible concept?
A Bender, JL Jenkins, M Glick, Z Deng, JH Nettles, JW Davies
Journal of chemical information and modeling 46 (6), 2445-2456, 2006
Dual allosteric inhibition of SHP2 phosphatase
M Fodor, E Price, P Wang, H Lu, A Argintaru, Z Chen, M Glick, HX Hao, ...
ACS chemical biology 13 (3), 647-656, 2018
Soluble T cell receptor
BK Jakobsen, M Glick
US Patent 7,329,731, 2008
The CD8 T cell coreceptor exhibits disproportionate biological activity at extremely low binding affinities
SL Hutchinson, L Wooldridge, S Tafuro, B Laugel, M Glick, JM Boulter, ...
Journal of Biological Chemistry 278 (27), 24285-24293, 2003
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