| Formation of the covalent serpin-proteinase complex involves translocation of the proteinase by more than 70 Å and full insertion of the reactive center loop into β-sheet A E Stratikos, PGW Gettins Proceedings of the National Academy of Sciences 96 (9), 4808-4813, 1999 | 277 | 1999 |
| Structural basis for antigenic peptide precursor processing by the endoplasmic reticulum aminopeptidase ERAP1 TT Nguyen, SC Chang, I Evnouchidou, IA York, C Zikos, KL Rock, ... Nature structural & molecular biology 18 (5), 604-613, 2011 | 236 | 2011 |
| Human cytomegalovirus microRNA miR-US4-1 inhibits CD8+ T cell responses by targeting the aminopeptidase ERAP1 S Kim, S Lee, J Shin, Y Kim, I Evnouchidou, D Kim, YK Kim, YE Kim, ... Nature immunology 12 (10), 984-991, 2011 | 230 | 2011 |
| Major proteinase movement upon stable serpin–proteinase complex formation E Stratikos, PGW Gettins Proceedings of the National Academy of Sciences 94 (2), 453-458, 1997 | 170 | 1997 |
| Cutting Edge: Coding single nucleotide polymorphisms of endoplasmic reticulum aminopeptidase 1 can affect antigenic peptide generation in vitro by influencing basic enzymatic … I Evnouchidou, RP Kamal, SS Seregin, Y Goto, M Tsujimoto, A Hattori, ... The Journal of Immunology 186 (4), 1909-1913, 2011 | 158 | 2011 |
| The internal sequence of the peptide-substrate determines its N-terminus trimming by ERAP1 I Evnouchidou, F Momburg, A Papakyriakou, A Chroni, L Leondiadis, ... PloS one 3 (11), e3658, 2008 | 129 | 2008 |
| Rationally designed inhibitor targeting antigen-trimming aminopeptidases enhances antigen presentation and cytotoxic T-cell responses E Zervoudi, E Saridakis, JR Birtley, SS Seregin, E Reeves, P Kokkala, ... Proceedings of the National Academy of Sciences 110 (49), 19890-19895, 2013 | 125 | 2013 |
| Probing the S1 specificity pocket of the aminopeptidases that generate antigenic peptides E Zervoudi, A Papakyriakou, D Georgiadou, I Evnouchidou, A Gajda, ... Biochemical Journal 435 (2), 411-420, 2011 | 117 | 2011 |
| The crystal structure of human endoplasmic reticulum aminopeptidase 2 reveals the atomic basis for distinct roles in antigen processing JR Birtley, E Saridakis, E Stratikos, IM Mavridis Biochemistry 51 (1), 286-295, 2012 | 115 | 2012 |
| A common single nucleotide polymorphism in endoplasmic reticulum aminopeptidase 2 induces a specificity switch that leads to altered antigen processing I Evnouchidou, J Birtley, S Seregin, A Papakyriakou, E Zervoudi, ... The Journal of Immunology 189 (5), 2383-2392, 2012 | 90 | 2012 |
| Enhanced catalytic action of HLA-DM on the exchange of peptides lacking backbone hydrogen bonds between their N-terminal region and the MHC class II α-chain E Stratikos, DC Wiley, LJ Stern The Journal of Immunology 172 (2), 1109-1117, 2004 | 88 | 2004 |
| Structural basis for antigenic peptide recognition and processing by endoplasmic reticulum (ER) aminopeptidase 2 A Mpakali, P Giastas, N Mathioudakis, IM Mavridis, E Saridakis, ... Journal of Biological Chemistry 290 (43), 26021-26032, 2015 | 85 | 2015 |
| A role for naturally occurring alleles of endoplasmic reticulum aminopeptidases in tumor immunity and cancer pre-disposition E Stratikos, A Stamogiannos, E Zervoudi, D Fruci Frontiers in oncology 4, 363, 2014 | 80 | 2014 |
| Endoplasmic reticulum aminopeptidase-1 alleles associated with increased risk of ankylosing spondylitis reduce HLA-B27 mediated presentation of multiple antigens SS Seregin, DPW Rastall, I Evnouchidou, CF Aylsworth, D Quiroga, ... Autoimmunity 46 (8), 497-508, 2013 | 76 | 2013 |
| Recombinant human pigment epithelium‐derived factor (PEDF): characterization of PEDF overexpressed and secreted by eukaryotic cells E Stratikos, E Alberdi, PGW Gettins, SP Becerra Protein Science 5 (12), 2575-2582, 1996 | 76 | 1996 |
| The role of antigen processing and presentation in cancer and the efficacy of immune checkpoint inhibitor immunotherapy A Mpakali, E Stratikos Cancers 13 (1), 134, 2021 | 74 | 2021 |
| Mapping the serpin-proteinase complex using single cysteine variants of α1-proteinase inhibitor Pittsburgh E Stratikos, PGW Gettins Journal of Biological Chemistry 273 (25), 15582-15589, 1998 | 69 | 1998 |
| Effects of polymorphic variation on the mechanism of Endoplasmic Reticulum Aminopeptidase 1 A Stamogiannos, D Koumantou, A Papakyriakou, E Stratikos Molecular immunology 67 (2), 426-435, 2015 | 66 | 2015 |
| Optimization and structure–activity relationships of phosphinic pseudotripeptide inhibitors of aminopeptidases that generate antigenic peptides P Kokkala, A Mpakali, FX Mauvais, A Papakyriakou, I Daskalaki, ... Journal of Medicinal Chemistry 59 (19), 9107-9123, 2016 | 63 | 2016 |
| Self-healing pH-and enzyme stimuli-responsive hydrogels for targeted delivery of gemcitabine to treat pancreatic cancer P Bilalis, D Skoulas, A Karatzas, J Marakis, A Stamogiannos, C Tsimblouli, ... Biomacromolecules 19 (9), 3840-3852, 2018 | 60 | 2018 |
Athanasios PapakyriakouInstitute of Biosciences and Applications, NCSR "Demokritos"Verified email at bio.demokritos.gr
