| The surface protein TIGIT suppresses T cell activation by promoting the generation of mature immunoregulatory dendritic cells X Yu, K Harden, L C Gonzalez, M Francesco, E Chiang, B Irving, I Tom, ... Nature immunology 10 (1), 48-57, 2009 | 1389 | 2009 |
| The cytoplasmic domain of the T cell receptor ζ chain is sufficient to couple to receptor-associated signal transduction pathways BA Irving, A Weiss Cell 64 (5), 891-901, 1991 | 1098 | 1991 |
| The immunoreceptor TIGIT regulates antitumor and antiviral CD8+ T cell effector function RJ Johnston, L Comps-Agrar, J Hackney, X Yu, M Huseni, Y Yang, S Park, ... Cancer cell 26 (6), 923-937, 2014 | 1093 | 2014 |
| Sequential interactions of the TCR with two distinct cytoplasmic tyrosine kinases M Iwashima, BA Irving, NSC Van Oers, AC Chan, A Weiss Science 263 (5150), 1136-1139, 1994 | 951 | 1994 |
| Regulation of interleukin-2 gene enhancer activity by the T cell accessory molecule CD28 JD Fraser, BA Irving, GR Crabtree, A Weiss Science 251 (4991), 313-316, 1991 | 901 | 1991 |
| Interaction of the unique N-terminal region of tyrosine kinase p56lck with cytoplasmic domains of CD4 and CD8 is mediated by cysteine motifs JM Turner, MH Brodsky, BA Irving, SD Levin, RM Perlmutter, DR Littman Cell 60 (5), 755-765, 1990 | 852 | 1990 |
| Molecular pathways: next-generation immunotherapy—inhibiting programmed death-ligand 1 and programmed death-1 DS Chen, BA Irving, FS Hodi Clinical cancer research 18 (24), 6580-6587, 2012 | 713 | 2012 |
| MAP kinase inhibition promotes T cell and anti-tumor activity in combination with PD-L1 checkpoint blockade PJR Ebert, J Cheung, Y Yang, E McNamara, R Hong, M Moskalenko, ... Immunity 44 (3), 609-621, 2016 | 659 | 2016 |
| Anti-PD-L1 antibodies, compositions and articles of manufacture B Irving, H Chiu, H Maecker, S Mariathasan, SM Lehar, Y Wu, J Cheung US Patent 8,217,149, 2012 | 619 | 2012 |
| The zeta chain is associated with a tyrosine kinase and upon T-cell antigen receptor stimulation associates with ZAP-70, a 70-kDa tyrosine phosphoprotein. AC Chan, BA Irving, JD Fraser, A Weiss Proceedings of the National Academy of Sciences 88 (20), 9166-9170, 1991 | 557 | 1991 |
| Bruton tyrosine kinase–dependent immune cell cross-talk drives pancreas cancer AJ Gunderson, MM Kaneda, T Tsujikawa, AV Nguyen, NI Affara, B Ruffell, ... Cancer discovery 6 (3), 270-285, 2016 | 455 | 2016 |
| Chimeric chains for receptor-associated signal transduction pathways DJ Capon, A Weiss, BA Irving, MR Roberts, K Zsebo US Patent 5,359,046, 1994 | 452 | 1994 |
| Functional characterization of a signal transducing motif present in the T cell antigen receptor zeta chain. BA Irving, AC Chan, A Weiss The Journal of experimental medicine 177 (4), 1093-1103, 1993 | 411 | 1993 |
| Role of PD-1 during effector CD8 T cell differentiation E Ahn, K Araki, M Hashimoto, W Li, JL Riley, J Cheung, AH Sharpe, ... Proceedings of the National Academy of Sciences 115 (18), 4749-4754, 2018 | 402 | 2018 |
| Tumour and host cell PD-L1 is required to mediate suppression of anti-tumour immunity in mice J Lau, J Cheung, A Navarro, S Lianoglou, B Haley, K Totpal, L Sanders, ... Nature communications 8 (1), 14572, 2017 | 352 | 2017 |
| B cells regulate macrophage phenotype and response to chemotherapy in squamous carcinomas NI Affara, B Ruffell, TR Medler, AJ Gunderson, M Johansson, S Bornstein, ... Cancer cell 25 (6), 809-821, 2014 | 304 | 2014 |
| Thymocyte development in the absence of pre-T cell receptor extracellular immunoglobulin domains BA Irving, FW Alt, N Killeen Science 280 (5365), 905-908, 1998 | 260 | 1998 |
| Antitumor efficacy of a bispecific antibody that targets HER2 and activates T cells TT Junttila, J Li, J Johnston, M Hristopoulos, R Clark, D Ellerman, ... Cancer research 74 (19), 5561-5571, 2014 | 157 | 2014 |
| Chimeric chains for receptor-associated signal transduction pathways DJ Capon, A Weiss, BA Irving, MR Roberts, K Zsebo US Patent 6,319,494, 2001 | 135 | 2001 |
| Methods of treating cancer using PD-1 axis binding antagonists and TIGIT inhibitors J Grogan, RJ Johnston, B Irving, J Hackney, X Yu, D Eaton, K Bowles, ... US Patent 9,873,740, 2018 | 95 | 2018 |
