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David Keire
David Keire
Division Director, US FDA
Verified email at fda.hhs.gov
Title
Cited by
Cited by
Year
Primary structures of PYY, [Pro34]PYY, and PYY-(3–36) confer different conformations and receptor selectivity
DA Keire, P Mannon, M Kobayashi, JH Walsh, TE Solomon, JR Reeve Jr
American Journal of Physiology-Gastrointestinal and Liver Physiology 279 (1 …, 2000
1812000
Kinetics and equilibria of thiol/disulfide interchange reactions of selected biological thiols and related molecules with oxidized glutathione
DA Keire, E Strauss, W Guo, B Noszal, DL Rabenstein
The Journal of Organic Chemistry 57 (1), 123-127, 1992
1641992
Daily, intermittent intravenous infusion of peptide YY (3-36) reduces daily food intake and adiposity in rats
PK Chelikani, AC Haver, JR Reeve Jr, DA Keire, RD Reidelberger
American Journal of Physiology-Regulatory, Integrative and Comparative …, 2006
1342006
Structure and receptor binding of PYY analogs
DA Keire, CW Bowers, TE Solomon, JR Reeve Jr
Peptides 23 (2), 305-321, 2002
1332002
The US regulatory and pharmacopeia response to the global heparin contamination crisis
AY Szajek, E Chess, K Johansen, G Gratzl, E Gray, D Keire, RJ Linhardt, ...
Nature biotechnology 34 (6), 625-630, 2016
1162016
CCK-58 is the only detectable endocrine form of cholecystokinin in rat
JR Reeve Jr, GM Green, P Chew, VE Eysselein, DA Keire
American Journal of Physiology-Gastrointestinal and Liver Physiology 285 (2 …, 2003
1112003
A retrospective evaluation of the use of mass spectrometry in FDA biologics license applications
S Rogstad, A Faustino, A Ruth, D Keire, M Boyne, J Park
Journal of the American Society for Mass Spectrometry 28 (5), 786-794, 2016
1092016
Mechanism and energetics for complexation of 90Y with 1, 4, 7, 10-tetraazacyclododecane-1, 4, 7, 10-tetraacetic acid (DOTA), a model for cancer radioimmunotherapy
YH Jang, M Blanco, S Dasgupta, DA Keire, JE Shively, WA Goddard
Journal of the American Chemical Society 121 (26), 6142-6151, 1999
1051999
The RAPID method for blood processing yields new insight in plasma concentrations and molecular forms of circulating gut peptides
A Stengel, D Keire, M Goebel, L Evilevitch, B Wiggins, Y Tache, ...
Endocrinology 150 (11), 5113-5118, 2009
962009
Solution Structure of Monomeric Peptide YY Supports the Functional Significance of the PP-Fold,
DA Keire, M Kobayashi, TE Solomon, JR Reeve
Biochemistry 39 (32), 9935-9942, 2000
922000
Analysis of crude heparin by 1H NMR, capillary electrophoresis, and strong-anion-exchange-HPLC for contamination by over sulfated chondroitin sulfate
DA Keire, ML Trehy, JC Reepmeyer, RE Kolinski, W Ye, J Dunn, ...
Journal of pharmaceutical and biomedical analysis 51 (4), 921-926, 2010
812010
Enabling adoption of 2D-NMR for the higher order structure assessment of monoclonal antibody therapeutics
RG Brinson, JP Marino, F Delaglio, LW Arbogast, RM Evans, A Kearsley, ...
MAbs 11 (1), 94-105, 2019
742019
The conformation of substance P in lipid environments
DA Keire, TG Fletcher
Biophysical journal 70 (4), 1716-1727, 1996
691996
Precision and robustness of 2D-NMR for structure assessment of filgrastim biosimilars
H Ghasriani, DJ Hodgson, RG Brinson, I McEwen, LF Buhse, S Kozlowski, ...
Nature biotechnology 34 (2), 139-141, 2016
682016
The interaction of β‐amyloid protein fragment (12‐28) with lipid environments
TG Fletcher, DA Keire
Protein science 6 (3), 666-675, 1997
681997
Diversifying the global heparin supply chain: reintroduction of bovine heparin in the United States?
A Szajek, E Gray, D Keire, B Mulloy, A Al-Hakim, C Chase, MDLC Soares, ...
Pharmaceutical Technology 39 (11), 2015
672015
Structural comparison of two anti-CD20 monoclonal antibody drug products using middle-down mass spectrometry
B Wang, AC Gucinski, DA Keire, LF Buhse, MT Boyne II
Analyst 138 (10), 3058-3065, 2013
582013
Characterization of currently marketed heparin products: reversed-phase ion-pairing liquid chromatography mass spectrometry of heparin digests
AM Brustkern, LF Buhse, M Nasr, A Al-Hakim, DA Keire
Analytical chemistry 82 (23), 9865-9870, 2010
562010
A Cautionary Tale: Quantitative LC-HRMS Analytical Procedures for the Analysis of N-Nitrosodimethylamine in Metformin
J Yang, W Ye, CD Sommers, JD Rodriguez, DA Keire
The AAPS Journal 22, 1-8, 2020
512020
Quantitative chemical analysis by NMR
DL Rabenstein, DA Keire
Modern NMR techniques and their application in chemistry, 1991
511991
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