Stephen Neidle
Stephen Neidle
Emeritus Professor of Chemical Biology, The UCL School of Pharmacy, University of London
Η διεύθυνση ηλεκτρονικού ταχυδρομείου έχει επαληθευτεί στον τομέα - Αρχική σελίδα
Παρατίθεται από
Παρατίθεται από
Quadruplex DNA: sequence, topology and structure
S Burge, GN Parkinson, P Hazel, AK Todd, S Neidle
Nucleic acids research 34 (19), 5402-5415, 2006
Crystal structure of parallel quadruplexes from human telomeric DNA
GN Parkinson, MPH Lee, S Neidle
Nature 417 (6891), 876-880, 2002
Targeting G-quadruplexes in gene promoters: a novel anticancer strategy?
S Balasubramanian, LH Hurley, S Neidle
Nature reviews Drug discovery 10 (4), 261-275, 2011
Nucleic acids in chemistry and biology
GM Blackburn, MJ Gait, D Loakes, DM Williams, JA Grasby, M Egli, ...
Royal Society of Chemistry, 2006
Highly prevalent putative quadruplex sequence motifs in human DNA
AK Todd, M Johnston, S Neidle
Nucleic acids research 33 (9), 2901-2907, 2005
Inhibition of human telomerase by a G-quadruplex-interactive compound
D Sun, B Thompson, BE Cathers, M Salazar, SM Kerwin, JO Trent, ...
Journal of medicinal chemistry 40 (14), 2113-2116, 1997
Telomere maintenance as a target for anticancer drug discovery
S Neidle, G Parkinson
Nature Reviews Drug Discovery 1 (5), 383-393, 2002
A standard reference frame for the description of nucleic acid base-pair geometry
WK Olson, M Bansal, SK Burley, RE Dickerson, M Gerstein, SC Harvey, ...
Journal of molecular biology 313 (1), 229-237, 2001
Putative DNA Quadruplex Formation within the Human c-kit Oncogene
S Rankin, AP Reszka, J Huppert, M Zloh, GN Parkinson, AK Todd, ...
Journal of the American Chemical Society 127 (30), 10584-10589, 2005
The G-quadruplex-interactive molecule BRACO-19 inhibits tumor growth, consistent with telomere targeting and interference with telomerase function
AM Burger, F Dai, CM Schultes, AP Reszka, MJ Moore, JA Double, ...
Cancer research 65 (4), 1489-1496, 2005
Human telomeric G‐quadruplex: The current status of telomeric G‐quadruplexes as therapeutic targets in human cancer
S Neidle
The FEBS journal 277 (5), 1118-1125, 2010
DNA minor-groove recognition by small molecules
S Neidle
Natural product reports 18 (3), 291-309, 2001
G-quadruplex nucleic acids as therapeutic targets
S Balasubramanian, S Neidle
Current opinion in chemical biology 13 (3), 345-353, 2009
Structure-based design of selective and potent G quadruplex-mediated telomerase inhibitors
M Read, RJ Harrison, B Romagnoli, FA Tanious, SH Gowan, AP Reszka, ...
Proceedings of the National Academy of Sciences 98 (9), 4844-4849, 2001
Quadruplex nucleic acids
S Neidle, S Balasubramanian
Royal Society of Chemistry, 2006
The structure of telomeric DNA
S Neidle, GN Parkinson
Current opinion in structural biology 13 (3), 275-283, 2003
The structures of quadruplex nucleic acids and their drug complexes
S Neidle
Current opinion in structural biology 19 (3), 239-250, 2009
Loop-length-dependent folding of G-quadruplexes
P Hazel, J Huppert, S Balasubramanian, S Neidle
Journal of the American Chemical Society 126 (50), 16405-16415, 2004
Structure of an Unprecedented G-Quadruplex Scaffold in the Human c-kit Promoter
AT Phan, V Kuryavyi, S Burge, S Neidle, DJ Patel
Journal of the American Chemical Society 129 (14), 4386-4392, 2007
A conserved quadruplex motif located in a transcription activation site of the human c-kit oncogene
H Fernando, AP Reszka, J Huppert, S Ladame, S Rankin, ...
Biochemistry 45 (25), 7854-7860, 2006
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