| Binding of serotonin to the human serotonin transporter. Molecular modeling and experimental validation L Celik, S Sinning, K Severinsen, CG Hansen, MS Møller, M Bols, ... Journal of the American Chemical Society 130 (12), 3853-3865, 2008 | 141 | 2008 |
| Directed evolution of a selective and sensitive serotonin sensor via machine learning EK Unger, JP Keller, M Altermatt, R Liang, A Matsui, C Dong, OJ Hon, ... Cell 183 (7), 1986-2002. e26, 2020 | 139 | 2020 |
| Binding and orientation of tricyclic antidepressants within the central substrate site of the human serotonin transporter S Sinning, M Musgaard, M Jensen, K Severinsen, L Celik, H Koldsø, ... Journal of biological chemistry 285 (11), 8363-8374, 2010 | 95 | 2010 |
| The two enantiomers of citalopram bind to the human serotonin transporter in reversed orientations H Koldsø, K Severinsen, TT Tran, L Celik, HH Jensen, O Wiborg, ... Biophysical Journal 98 (3), 428a, 2010 | 91 | 2010 |
| A direct interaction of cholesterol with the dopamine transporter prevents its out-to-inward transition T Zeppelin, LK Ladefoged, S Sinning, X Periole, B Schiøtt PLoS computational biology 14 (1), e1005907, 2018 | 84 | 2018 |
| Structural insights into the inhibition of glycine reuptake A Shahsavar, P Stohler, G Bourenkov, I Zimmermann, M Siegrist, W Guba, ... Nature 591 (7851), 677-681, 2021 | 70 | 2021 |
| Cholesterol binding to a conserved site modulates the conformation, pharmacology, and transport kinetics of the human serotonin transporter L Laursen, K Severinsen, KB Kristensen, X Periole, M Overby, HK Müller, ... Journal of Biological Chemistry 293 (10), 3510-3523, 2018 | 63 | 2018 |
| A conserved leucine occupies the empty substrate site of LeuT in the Na+-free return state L Malinauskaite, S Said, C Sahin, J Grouleff, A Shahsavar, H Bjerregaard, ... Nature communications 7 (1), 11673, 2016 | 61 | 2016 |
| Unbiased Simulations Reveal the Inward-Facing Conformation of the Human Serotonin Transporter and Na+ Ion Release H Koldsø, P Noer, J Grouleff, HE Autzen, S Sinning, B Schiøtt PLoS computational biology 7 (10), e1002246, 2011 | 60 | 2011 |
| Comparative modeling of the human monoamine transporters: similarities in substrate binding H Koldsø, AB Christiansen, S Sinning, B Schiøtt ACS chemical neuroscience 4 (2), 295-309, 2013 | 58 | 2013 |
| Synthesis of 3, 7‐Disubstituted Imipramines by Palladium‐Catalysed Amination/Cyclisation and Evaluation of Their Inhibition of Monoamine Transporters H Christensen, C Schjøth‐Eskesen, M Jensen, S Sinning, HH Jensen Chemistry–A European Journal 17 (38), 10618-10627, 2011 | 50 | 2011 |
| Synthesis of 3, 7‐Disubstituted Imipramines by Palladium‐Catalysed Amination/Cyclisation and Evaluation of Their Inhibition of Monoamine Transporters H Christensen, C Schjøth‐Eskesen, M Jensen, S Sinning, HH Jensen Chemistry–A European Journal 17 (38), 10618-10627, 2011 | 50 | 2011 |
| Binding of the amphetamine-like 1-phenyl-piperazine to monoamine transporters K Severinsen, JF Kraft, H Koldsø, KA Vinberg, RB Rothman, JS Partilla, ... ACS chemical neuroscience 3 (9), 693-705, 2012 | 31 | 2012 |
| A dualistic conformational response to substrate binding in the human serotonin transporter reveals a high affinity state for serotonin H Bjerregaard, K Severinsen, S Said, O Wiborg, S Sinning Journal of Biological Chemistry 290 (12), 7747-7755, 2015 | 30 | 2015 |
| Characterisation of the zebrafish serotonin transporter functionally links TM10 to the ligand binding site K Severinsen, S Sinning, HK Müller, O Wiborg Journal of neurochemistry 105 (5), 1794-1805, 2008 | 30 | 2008 |
| Combinatorial synthesis of benztropine libraries and their evaluation as monoamine transporter inhibitors H Pedersen, S Sinning, A Bülow, O Wiborg, L Falborg, M Bols Organic & biomolecular chemistry 2 (19), 2861-2869, 2004 | 29 | 2004 |
| Structural elements required for coupling ion and substrate transport in the neurotransmitter transporter homolog LeuT YW Zhang, S Tavoulari, S Sinning, AA Aleksandrova, LR Forrest, ... Proceedings of the National Academy of Sciences 115 (38), E8854-E8862, 2018 | 28 | 2018 |
| Synthesis, inhibition and binding of simple non-nitrogen inhibitors of monoamine transporters MD Petersen, SV Boye, EH Nielsen, J Willumsen, S Sinning, O Wiborg, ... Bioorganic & medicinal chemistry 15 (12), 4159-4174, 2007 | 28 | 2007 |
| Binding of mazindol and analogs to the human serotonin and dopamine transporters K Severinsen, H Koldsø, KAV Thorup, C Schjøth-Eskesen, PT Møller, ... Molecular pharmacology 85 (2), 208-217, 2014 | 23 | 2014 |
| QSAR studies and pharmacophore identification for arylsubstituted cycloalkenecarboxylic acid methyl esters with affinity for the human dopamine transporter HS Christensen, SV Boye, J Thinggaard, S Sinning, O Wiborg, B Schiøtt, ... Bioorganic & medicinal chemistry 15 (15), 5262-5274, 2007 | 22 | 2007 |
Birgit SchiøttProfessor of Chemistry, Aarhus UniversityVerified email at chem.au.dk
