| Venetoclax with azacitidine disrupts energy metabolism and targets leukemia stem cells in patients with acute myeloid leukemia DA Pollyea, BM Stevens, CL Jones, A Winters, S Pei, M Minhajuddin, ... Nature medicine 24 (12), 1859-1866, 2018 | 576 | 2018 |
| Inhibition of amino acid metabolism selectively targets human leukemia stem cells CL Jones, BM Stevens, A D'Alessandro, JA Reisz, R Culp-Hill, T Nemkov, ... Cancer cell 34 (5), 724-740. e4, 2018 | 447 | 2018 |
| p53 represses the mevalonate pathway to mediate tumor suppression SH Moon, CH Huang, SL Houlihan, K Regunath, WA Freed-Pastor, ... Cell 176 (3), 564-580. e19, 2019 | 316 | 2019 |
| The TP53 apoptotic network is a primary mediator of resistance to BCL2 inhibition in AML cells T Nechiporuk, SE Kurtz, O Nikolova, T Liu, CL Jones, A D'Alessandro, ... Cancer discovery 9 (7), 910-925, 2019 | 256 | 2019 |
| Fatty acid metabolism underlies venetoclax resistance in acute myeloid leukemia stem cells BM Stevens, CL Jones, DA Pollyea, R Culp-Hill, A D’Alessandro, ... Nature cancer 1 (12), 1176-1187, 2020 | 179 | 2020 |
| Nicotinamide metabolism mediates resistance to venetoclax in relapsed acute myeloid leukemia stem cells CL Jones, BM Stevens, DA Pollyea, R Culp-Hill, JA Reisz, T Nemkov, ... Cell stem cell 27 (5), 748-764. e4, 2020 | 154 | 2020 |
| Cysteine depletion targets leukemia stem cells through inhibition of electron transport complex II CL Jones, BM Stevens, A D’Alessandro, R Culp-Hill, JA Reisz, S Pei, ... Blood, The Journal of the American Society of Hematology 134 (4), 389-394, 2019 | 128 | 2019 |
| A role for tryptophan-2, 3-dioxygenase in CD8 T-cell suppression and evidence of tryptophan catabolism in breast cancer patient plasma LI Greene, TC Bruno, JL Christenson, A D'Alessandro, R Culp-Hill, ... Molecular Cancer Research 17 (1), 131-139, 2019 | 106 | 2019 |
| Donor sex, age and ethnicity impact stored red blood cell antioxidant metabolism through mechanisms in part explained by glucose 6-phosphate dehydrogenase levels and activity A D’Alessandro, X Fu, T Kanias, JA Reisz, R Culp-Hill, Y Guo, ... Haematologica 106 (5), 1290, 2021 | 103 | 2021 |
| Mitochondrial ATP fuels ABC transporter-mediated drug efflux in cancer chemoresistance EL Giddings, DP Champagne, MH Wu, JM Laffin, TM Thornton, ... Nature communications 12 (1), 2804, 2021 | 89 | 2021 |
| Trisomy 21 activates the kynurenine pathway via increased dosage of interferon receptors RK Powers, R Culp-Hill, MP Ludwig, KP Smith, KA Waugh, R Minter, ... Nature communications 10 (1), 4766, 2019 | 79 | 2019 |
| Interactions between host genetics and gut microbiota determine susceptibility to CNS autoimmunity TL Montgomery, A Künstner, JJ Kennedy, Q Fang, L Asarian, R Culp-Hill, ... Proceedings of the National Academy of Sciences 117 (44), 27516-27527, 2020 | 75 | 2020 |
| Methylation of protein aspartates and deamidated asparagines as a function of blood bank storage and oxidative stress in human red blood cells JA Reisz, T Nemkov, M Dzieciatkowska, R Culp‐Hill, D Stefanoni, RC Hill, ... Transfusion 58 (12), 2978-2991, 2018 | 74 | 2018 |
| Heterogeneity of blood processing and storage additives in different centers impacts stored red blood cell metabolism as much as storage time: lessons from REDS‐III—Omics A D'Alessandro, R Culp‐Hill, JA Reisz, M Anderson, X Fu, T Nemkov, ... Transfusion 59 (1), 89-100, 2019 | 73 | 2019 |
| Differences in Steap3 expression are a mechanism of genetic variation of RBC storage and oxidative damage in mice HL Howie, AM Hay, K de Wolski, H Waterman, J Lebedev, X Fu, ... Blood Advances 3 (15), 2272-2285, 2019 | 65 | 2019 |
| Metabolic effect of alkaline additives and guanosine/gluconate in storage solutions for red blood cells A D'Alessandro, JA Reisz, R Culp‐Hill, H Korsten, R van Bruggen, ... Transfusion 58 (8), 1992-2002, 2018 | 56 | 2018 |
| Inhibition of amino acid metabolism selectively targets human leukemia stem cells CL Jones, BM Stevens, A D’Alessandro, JA Reisz, R Culp-Hill, T Nemkov, ... Cancer Cell 35 (2), 333-335, 2019 | 48 | 2019 |
| Short‐term interleukin‐37 treatment improves vascular endothelial function, endurance exercise capacity, and whole‐body glucose metabolism in old mice DB Ballak, VE Brunt, ZJ Sapinsley, BP Ziemba, JJ Richey, MC Zigler, ... Aging Cell 19 (1), e13074, 2020 | 42 | 2020 |
| Extinguishing the embers: targeting AML metabolism R Culp-Hill, A D’Alessandro, EM Pietras Trends in molecular medicine 27 (4), 332-344, 2021 | 40 | 2021 |
| Transfusional iron overload and intravenous iron infusions modify the mouse gut microbiota similarly to dietary iron F La Carpia, BS Wojczyk, MK Annavajhala, A Rebbaa, R Culp-Hill, ... npj Biofilms and Microbiomes 5 (1), 26, 2019 | 39 | 2019 |
