| Regulatory R region of the CFTR chloride channel is a dynamic integrator of phospho-dependent intra-and intermolecular interactions Z Bozoky, M Krzeminski, R Muhandiram, JR Birtley, A Al-Zahrani, ... Proceedings of the National Academy of Sciences 110 (47), E4427-E4436, 2013 | 172 | 2013 |
| Crystal structure of foot-and-mouth disease virus 3C protease: new insights into catalytic mechanism and cleavage specificity JR Birtley, SR Knox, AM Jaulent, P Brick, RJ Leatherbarrow, S Curry Journal of Biological Chemistry 280 (12), 11520-11527, 2005 | 162 | 2005 |
| Rationally designed inhibitor targeting antigen-trimming aminopeptidases enhances antigen presentation and cytotoxic T-cell responses E Zervoudi, E Saridakis, JR Birtley, SS Seregin, E Reeves, P Kokkala, ... Proceedings of the National Academy of Sciences 110 (49), 19890-19895, 2013 | 125 | 2013 |
| Rationally designed inhibitor targeting antigen-trimming aminopeptidases enhances antigen presentation and cytotoxic T-cell responses E Zervoudi, E Saridakis, JR Birtley, SS Seregin, E Reeves, P Kokkala, ... Proceedings of the National Academy of Sciences 110 (49), 19890-19895, 2013 | 125 | 2013 |
| The crystal structure of human endoplasmic reticulum aminopeptidase 2 reveals the atomic basis for distinct roles in antigen processing JR Birtley, E Saridakis, E Stratikos, IM Mavridis Biochemistry 51 (1), 286-295, 2012 | 115 | 2012 |
| Structural insights into the transcriptional and translational roles of Ebp1 TP Monie, AJ Perrin, JR Birtley, TR Sweeney, I Karakasiliotis, Y Chaudhry, ... The EMBO journal 26 (17), 3936-3944, 2007 | 111 | 2007 |
| Structural and mutagenic analysis of foot-and-mouth disease virus 3C protease reveals the role of the β-ribbon in proteolysis TR Sweeney, N Roqué-Rosell, JR Birtley, RJ Leatherbarrow, S Curry Journal of virology 81 (1), 115-124, 2007 | 105 | 2007 |
| Role of RNA structure and RNA binding activity of foot-and-mouth disease virus 3C protein in VPg uridylylation and virus replication A Nayak, IG Goodfellow, KE Woolaway, J Birtley, S Curry, GJ Belsham Journal of virology 80 (19), 9865-9875, 2006 | 94 | 2006 |
| A common single nucleotide polymorphism in endoplasmic reticulum aminopeptidase 2 induces a specificity switch that leads to altered antigen processing I Evnouchidou, J Birtley, S Seregin, A Papakyriakou, E Zervoudi, ... The Journal of Immunology 189 (5), 2383-2392, 2012 | 90 | 2012 |
| Architecture of the cystic fibrosis transmembrane conductance regulator protein and structural changes associated with phosphorylation and nucleotide binding L Zhang, LA Aleksandrov, Z Zhao, JR Birtley, JR Riordan, RC Ford Journal of structural biology 167 (3), 242-251, 2009 | 72 | 2009 |
| Crystallization of foot-and-mouth disease virus 3C protease: surface mutagenesis and a novel crystal-optimization strategy JR Birtley, S Curry Acta Crystallographica Section D: Biological Crystallography 61 (5), 646-650, 2005 | 52 | 2005 |
| Structures of the compact helical core domains of feline calicivirus and murine norovirus VPg proteins EN Leen, KYR Kwok, JR Birtley, PJ Simpson, CV Subba-Reddy, ... Journal of virology 87 (10), 5318-5330, 2013 | 49 | 2013 |
| In vivo clonal expansion and phenotypes of hypocretin-specific CD4+ T cells in narcolepsy patients and controls W Jiang, JR Birtley, SC Hung, W Wang, SH Chiou, C Macaubas, ... Nature communications 10 (1), 5247, 2019 | 47 | 2019 |
| Shigella depends on SepA to destabilize the intestinal epithelial integrity via cofilin activation A Maldonado-Contreras, JR Birtley, E Boll, Y Zhao, KL Mumy, J Toscano, ... Gut Microbes 8 (6), 544-560, 2017 | 46 | 2017 |
| A continuous assay for foot-and-mouth disease virus 3C protease activity AM Jaulent, AS Fahy, SR Knox, JR Birtley, N Roqué-Rosell, S Curry, ... Analytical biochemistry 368 (2), 130-137, 2007 | 25 | 2007 |
| The allosteric modulation of complement C5 by knob domain peptides A Macpherson, M Laabei, Z Ahdash, MA Graewert, JR Birtley, ... Elife 10, e63586, 2021 | 24 | 2021 |
| CFTR three-dimensional structure RC Ford, J Birtley, MF Rosenberg, L Zhang Cystic Fibrosis: Diagnosis and Protocols, Volume I: Approaches to Study and …, 2011 | 15 | 2011 |
| Inactivating mutations and X-ray crystal structure of the tumor suppressor OPCML reveal cancer-associated functions JR Birtley, M Alomary, E Zanini, J Antony, Z Maben, GC Weaver, ... Nature communications 10 (1), 3134, 2019 | 13 | 2019 |
| The chemical synthesis of knob domain antibody fragments A Macpherson, JR Birtley, RJ Broadbridge, K Brady, MSED Schulze, ... ACS Chemical Biology 16 (9), 1757-1769, 2021 | 11 | 2021 |
| SepA Enhances Shigella Invasion of Epithelial Cells by Degrading Alpha-1 Antitrypsin and Producing a Neutrophil Chemoattractant M Meza-Segura, JR Birtley, A Maldonado-Contreras, C Mueller, KJ Simin, ... MBio 12 (6), e02833-21, 2021 | 9 | 2021 |
