| Islet amyloid in type 2 diabetes, and the toxic oligomer hypothesis L Haataja, T Gurlo, CJ Huang, PC Butler Endocrine reviews 29 (3), 303-316, 2008 | 712 | 2008 |
| Controlled induction of human pancreatic progenitors produces functional beta‐like cells in vitro HA Russ, AV Parent, JJ Ringler, TG Hennings, GG Nair, M Shveygert, ... The EMBO journal 34 (13), 1759-1772, 2015 | 601 | 2015 |
| High expression rates of human islet amyloid polypeptide induce endoplasmic reticulum stress–mediated β-cell apoptosis, a characteristic of humans with type 2 but not type 1 … C Huang, C Lin, L Haataja, T Gurlo, AE Butler, RA Rizza, PC Butler Diabetes 56 (8), 2016-2027, 2007 | 495 | 2007 |
| Characterization of RAC3, a novel member of the Rho family L Haataja, J Groffen, N Heisterkamp Journal of Biological Chemistry 272 (33), 20384-20388, 1997 | 342 | 1997 |
| CXCL10 impairs β cell function and viability in diabetes through TLR4 signaling FT Schulthess, F Paroni, NS Sauter, L Shu, P Ribaux, L Haataja, ... Cell metabolism 9 (2), 125-139, 2009 | 242 | 2009 |
| Inhibition of human IAPP fibril formation does not prevent β-cell death: evidence for distinct actions of oligomers and fibrils of human IAPP JJ Meier, R Kayed, CY Lin, T Gurlo, L Haataja, S Jayasinghe, R Langen, ... American Journal of Physiology-Endocrinology and Metabolism 291 (6), E1317-E1324, 2006 | 225 | 2006 |
| Toxic human islet amyloid polypeptide (h-IAPP) oligomers are intracellular, and vaccination to induce anti-toxic oligomer antibodies does not prevent h-IAPP–induced β-cell … CY Lin, T Gurlo, R Kayed, AE Butler, L Haataja, CG Glabe, PC Butler Diabetes 56 (5), 1324-1332, 2007 | 216 | 2007 |
| Biosynthesis, structure, and folding of the insulin precursor protein M Liu, MA Weiss, A Arunagiri, J Yong, N Rege, J Sun, L Haataja, ... Diabetes, Obesity and Metabolism 20, 28-50, 2018 | 197 | 2018 |
| Proinsulin misfolding and diabetes: mutant INS gene-induced diabetes of youth M Liu, I Hodish, L Haataja, R Lara-Lemus, G Rajpal, J Wright, P Arvan Trends in Endocrinology & Metabolism 21 (11), 652-659, 2010 | 187 | 2010 |
| Induction of endoplasmic reticulum stress-induced β-cell apoptosis and accumulation of polyubiquitinated proteins by human islet amyloid polypeptide C Huang, L Haataja, T Gurlo, AE Butler, X Wu, WC Soeller, PC Butler American Journal of Physiology-Endocrinology and Metabolism 293 (6), E1656-E1662, 2007 | 178 | 2007 |
| Cellular interactions of CRKL, an SH2–SH3 adaptor protein J ten Hoeve, V Kaartinen, T Fioretos, L Haataja, JW Voncken, ... Cancer research 54 (10), 2563-2567, 1994 | 153 | 1994 |
| Autophagy is a major regulator of beta cell insulin homeostasis Y Riahi, JD Wikstrom, E Bachar-Wikstrom, N Polin, H Zucker, MS Lee, ... Diabetologia 59, 1480-1491, 2016 | 142 | 2016 |
| Mutant INS-Gene Induced Diabetes of Youth: Proinsulin Cysteine Residues Impose Dominant-Negative Inhibition on Wild-Type Proinsulin Transport M Liu, L Haataja, J Wright, NP Wickramasinghe, QX Hua, NF Phillips, ... PloS one 5 (10), e13333, 2010 | 137 | 2010 |
| Impaired NH2-terminal processing of human proislet amyloid polypeptide by the prohormone convertase PC2 leads to amyloid formation and cell death L Marzban, CJ Rhodes, DF Steiner, L Haataja, PA Halban, CB Verchere Diabetes 55 (8), 2192-2201, 2006 | 129 | 2006 |
| Activation of peroxisome proliferator-activated receptor-γ by rosiglitazone protects human islet cells against human islet amyloid polypeptide toxicity by a … CY Lin, T Gurlo, L Haataja, WA Hsueh, PC Butler The Journal of Clinical Endocrinology & Metabolism 90 (12), 6678-6686, 2005 | 123 | 2005 |
| Calcium-activated calpain-2 is a mediator of beta cell dysfunction and apoptosis in type 2 diabetes C Huang, T Gurlo, L Haataja, S Costes, M Daval, S Ryazantsev, X Wu, ... Journal of Biological Chemistry 285 (1), 339-348, 2010 | 119 | 2010 |
| Proinsulin misfolding is an early event in the progression to type 2 diabetes A Arunagiri, L Haataja, A Pottekat, F Pamenan, S Kim, LM Zeltser, ... Elife 8, e44532, 2019 | 112 | 2019 |
| Pancreatic β-cell adaptive plasticity in obesity increases insulin production but adversely affects secretory function C Alarcon, BB Boland, Y Uchizono, PC Moore, B Peterson, S Rajan, ... Diabetes 65 (2), 438-450, 2016 | 112 | 2016 |
| Pancreatic β-cells secrete insulin in fast-and slow-release forms DJ Michael, RA Ritzel, L Haataja, RH Chow Diabetes 55 (3), 600-607, 2006 | 112 | 2006 |
| Persistence of pancreatic insulin mRNA expression and proinsulin protein in type 1 diabetes pancreata C Wasserfall, HS Nick, M Campbell-Thompson, D Beachy, L Haataja, ... Cell metabolism 26 (3), 568-575. e3, 2017 | 94 | 2017 |
