Douglas McCloskey
Douglas McCloskey
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Cited by
Tracing compartmentalized NADPH metabolism in the cytosol and mitochondria of mammalian cells
CA Lewis, SJ Parker, BP Fiske, D McCloskey, DY Gui, CR Green, ...
Molecular cell 55 (2), 253-263, 2014
Basic and applied uses of genome‐scale metabolic network reconstructions of Escherichia coli
D McCloskey, BŲ Palsson, AM Feist
Molecular systems biology 9 (1), 661, 2013
A white-box machine learning approach for revealing antibiotic mechanisms of action
JH Yang, SN Wright, M Hamblin, D McCloskey, MA Alcantar, ...
Cell 177 (6), 1649-1661. e9, 2019
Antibiotic-induced changes to the host metabolic environment inhibit drug efficacy and alter immune function
JH Yang, P Bhargava, D McCloskey, N Mao, BO Palsson, JJ Collins
Cell host & microbe 22 (6), 757-765. e3, 2017
Personalized whole-cell kinetic models of metabolism for discovery in genomics and pharmacodynamics
A Bordbar, D McCloskey, DC Zielinski, N Sonnenschein, N Jamshidi, ...
Cell systems 1 (4), 283-292, 2015
AMPD2 Regulates GTP Synthesis and Is Mutated in a Potentially Treatable Neurodegenerative Brainstem Disorder
N Akizu, V Cantagrel, J Schroth, N Cai, K Vaux, D McCloskey, ...
Cell 154 (3), 505-517, 2013
Global rebalancing of cellular resources by pleiotropic point mutations illustrates a multi-scale mechanism of adaptive evolution
J Utrilla, EJ O’Brien, K Chen, D McCloskey, J Cheung, H Wang, ...
Cell systems 2 (4), 260-271, 2016
Characterizing strain variation in engineered E. coli using a multi-omics-based workflow
E Brunk, KW George, J Alonso-Gutierrez, M Thompson, E Baidoo, ...
Cell systems 2 (5), 335-346, 2016
Better shrinkage than shrinky-dinks
D Nguyen, D Taylor, K Qian, N Norouzi, J Rasmussen, S Botzet, ...
Lab on a Chip 10 (12), 1623-1626, 2010
A model‐driven quantitative metabolomics analysis of aerobic and anaerobic metabolism in E. coli K‐12 MG1655 that is biochemically and thermodynamically …
D McCloskey, JA Gangoiti, ZA King, RK Naviaux, BA Barshop, ...
Biotechnology and bioengineering 111 (4), 803-815, 2014
Evolution of gene knockout strains of E. coli reveal regulatory architectures governed by metabolism
D McCloskey, S Xu, TE Sandberg, E Brunk, Y Hefner, R Szubin, AM Feist, ...
Nature communications 9 (1), 1-15, 2018
MID max: LC–MS/MS method for measuring the precursor and product mass Isotopomer distributions of metabolic intermediates and cofactors for metabolic flux analysis applications
D McCloskey, JD Young, S Xu, BO Palsson, AM Feist
Analytical chemistry 88 (2), 1362-1370, 2016
Shrink film patterning by craft cutter: complete plastic chips with high resolution/high-aspect ratio channel
D Taylor, D Dyer, V Lew, M Khine
Lab on a Chip 10 (18), 2472-2475, 2010
A pH and solvent optimized reverse-phase ion-paring-LC–MS/MS method that leverages multiple scan-types for targeted absolute quantification of intracellular metabolites
D McCloskey, JA Gangoiti, BO Palsson, AM Feist
Metabolomics 11 (5), 1338-1350, 2015
Modeling method for increased precision and scope of directly measurable fluxes at a genome-scale
D McCloskey, JD Young, S Xu, BO Palsson, AM Feist
Analytical chemistry 88 (7), 3844-3852, 2016
Fast Swinnex filtration (FSF): a fast and robust sampling and extraction method suitable for metabolomics analysis of cultures grown in complex media
D McCloskey, J Utrilla, RK Naviaux, BO Palsson, AM Feist
Metabolomics 11 (1), 198-209, 2015
Laboratory evolution reveals a two-dimensional rate-yield tradeoff in microbial metabolism
C Cheng, EJ O’brien, D McCloskey, J Utrilla, C Olson, RA LaCroix, ...
PLoS computational biology 15 (6), e1007066, 2019
Adaptive laboratory evolution resolves energy depletion to maintain high aromatic metabolite phenotypes in Escherichia coli strains lacking the phosphotransferase system
D McCloskey, S Xu, TE Sandberg, E Brunk, Y Hefner, R Szubin, AM Feist, ...
Metabolic engineering 48, 233-242, 2018
Adaptation to the coupling of glycolysis to toxic methylglyoxal production in tpiA deletion strains of Escherichia coli requires synchronized and counterintuitive genetic changes
D McCloskey, S Xu, TE Sandberg, E Brunk, Y Hefner, R Szubin, AM Feist, ...
Metabolic engineering 48, 82-93, 2018
Multi-omics analysis of fatty alcohol production in engineered yeasts Saccharomyces cerevisiae and Yarrowia lipolytica
J Dahlin, C Holkenbrink, ER Marella, G Wang, U Liebal, C Lieven, ...
Frontiers in genetics, 747, 2019
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Articles 1–20