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Douglas McCloskey
Douglas McCloskey
Unknown affiliation
Verified email at eng.ucsd.edu
Title
Cited by
Cited by
Year
Tracing compartmentalized NADPH metabolism in the cytosol and mitochondria of mammalian cells
CA Lewis, SJ Parker, BP Fiske, D McCloskey, DY Gui, CR Green, ...
Molecular cell 55 (2), 253-263, 2014
4542014
Basic and applied uses of genome‐scale metabolic network reconstructions of Escherichia coli
D McCloskey, BŲ Palsson, AM Feist
Molecular systems biology 9 (1), 661, 2013
3802013
A white-box machine learning approach for revealing antibiotic mechanisms of action
JH Yang, SN Wright, M Hamblin, D McCloskey, MA Alcantar, ...
Cell 177 (6), 1649-1661. e9, 2019
1512019
Antibiotic-induced changes to the host metabolic environment inhibit drug efficacy and alter immune function
JH Yang, P Bhargava, D McCloskey, N Mao, BO Palsson, JJ Collins
Cell host & microbe 22 (6), 757-765. e3, 2017
1412017
Personalized whole-cell kinetic models of metabolism for discovery in genomics and pharmacodynamics
A Bordbar, D McCloskey, DC Zielinski, N Sonnenschein, N Jamshidi, ...
Cell systems 1 (4), 283-292, 2015
932015
AMPD2 Regulates GTP Synthesis and Is Mutated in a Potentially Treatable Neurodegenerative Brainstem Disorder
N Akizu, V Cantagrel, J Schroth, N Cai, K Vaux, D McCloskey, ...
Cell 154 (3), 505-517, 2013
922013
Global rebalancing of cellular resources by pleiotropic point mutations illustrates a multi-scale mechanism of adaptive evolution
J Utrilla, EJ O’Brien, K Chen, D McCloskey, J Cheung, H Wang, ...
Cell systems 2 (4), 260-271, 2016
782016
Characterizing strain variation in engineered E. coli using a multi-omics-based workflow
E Brunk, KW George, J Alonso-Gutierrez, M Thompson, E Baidoo, ...
Cell systems 2 (5), 335-346, 2016
772016
Better shrinkage than shrinky-dinks
D Nguyen, D Taylor, K Qian, N Norouzi, J Rasmussen, S Botzet, ...
Lab on a Chip 10 (12), 1623-1626, 2010
732010
A model‐driven quantitative metabolomics analysis of aerobic and anaerobic metabolism in E. coli K‐12 MG1655 that is biochemically and thermodynamically …
D McCloskey, JA Gangoiti, ZA King, RK Naviaux, BA Barshop, ...
Biotechnology and bioengineering 111 (4), 803-815, 2014
642014
Evolution of gene knockout strains of E. coli reveal regulatory architectures governed by metabolism
D McCloskey, S Xu, TE Sandberg, E Brunk, Y Hefner, R Szubin, AM Feist, ...
Nature communications 9 (1), 1-15, 2018
472018
MID max: LC–MS/MS method for measuring the precursor and product mass Isotopomer distributions of metabolic intermediates and cofactors for metabolic flux analysis applications
D McCloskey, JD Young, S Xu, BO Palsson, AM Feist
Analytical chemistry 88 (2), 1362-1370, 2016
462016
Shrink film patterning by craft cutter: complete plastic chips with high resolution/high-aspect ratio channel
D Taylor, D Dyer, V Lew, M Khine
Lab on a Chip 10 (18), 2472-2475, 2010
452010
A pH and solvent optimized reverse-phase ion-paring-LC–MS/MS method that leverages multiple scan-types for targeted absolute quantification of intracellular metabolites
D McCloskey, JA Gangoiti, BO Palsson, AM Feist
Metabolomics 11 (5), 1338-1350, 2015
352015
Modeling method for increased precision and scope of directly measurable fluxes at a genome-scale
D McCloskey, JD Young, S Xu, BO Palsson, AM Feist
Analytical chemistry 88 (7), 3844-3852, 2016
332016
Fast Swinnex filtration (FSF): a fast and robust sampling and extraction method suitable for metabolomics analysis of cultures grown in complex media
D McCloskey, J Utrilla, RK Naviaux, BO Palsson, AM Feist
Metabolomics 11 (1), 198-209, 2015
302015
Laboratory evolution reveals a two-dimensional rate-yield tradeoff in microbial metabolism
C Cheng, EJ O’brien, D McCloskey, J Utrilla, C Olson, RA LaCroix, ...
PLoS computational biology 15 (6), e1007066, 2019
272019
Adaptive laboratory evolution resolves energy depletion to maintain high aromatic metabolite phenotypes in Escherichia coli strains lacking the phosphotransferase system
D McCloskey, S Xu, TE Sandberg, E Brunk, Y Hefner, R Szubin, AM Feist, ...
Metabolic engineering 48, 233-242, 2018
272018
Adaptation to the coupling of glycolysis to toxic methylglyoxal production in tpiA deletion strains of Escherichia coli requires synchronized and counterintuitive genetic changes
D McCloskey, S Xu, TE Sandberg, E Brunk, Y Hefner, R Szubin, AM Feist, ...
Metabolic engineering 48, 82-93, 2018
262018
Multi-omics analysis of fatty alcohol production in engineered yeasts Saccharomyces cerevisiae and Yarrowia lipolytica
J Dahlin, C Holkenbrink, ER Marella, G Wang, U Liebal, C Lieven, ...
Frontiers in genetics, 747, 2019
232019
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