Perspectives on electrostatics and conformational motions in enzyme catalysis P Hanoian, CT Liu, S Hammes-Schiffer, S Benkovic Accounts of chemical research 48 (2), 482-489, 2015 | 163 | 2015 |
The unique chemistry of benzoxaboroles: current and emerging applications in biotechnology and therapeutic treatments CT Liu, JW Tomsho, SJ Benkovic Bioorganic & medicinal chemistry 22 (16), 4462-4473, 2014 | 121 | 2014 |
Probing the Electrostatics of Active Site Microenvironments along the Catalytic Cycle for Escherichia coli Dihydrofolate Reductase CT Liu, JP Layfield, RJ Stewart III, JB French, P Hanoian, JB Asbury, ... Journal of the American Chemical Society 136 (29), 10349-10360, 2014 | 106 | 2014 |
Functional significance of evolving protein sequence in dihydrofolate reductase from bacteria to humans CT Liu, P Hanoian, JB French, TH Pringle, S Hammes-Schiffer, ... Proceedings of the National Academy of Sciences 110 (25), 10159-10164, 2013 | 105 | 2013 |
The Dinuclear Zn (II) Complex Catalyzed Cyclization of a Series of 2-Hydroxypropyl Aryl Phosphate RNA Models: Progressive Change in Mechanism from Rate-Limiting P− O Bond … SE Bunn, CT Liu, ZL Lu, AA Neverov, RS Brown Journal of the American Chemical Society 129 (51), 16238-16248, 2007 | 85 | 2007 |
Escherichia coli dihydrofolate reductase catalyzed proton and hydride transfers: Temporal order and the roles of Asp27 and Tyr100 CT Liu, K Francis, JP Layfield, X Huang, S Hammes-Schiffer, A Kohen, ... Proceedings of the National Academy of Sciences 111 (51), 18231-18236, 2014 | 73 | 2014 |
Rapid three-step cleavage of RNA and DNA model systems promoted by a dinuclear Cu (II) complex in methanol. Energetic origins of the catalytic efficacy ZL Lu, CT Liu, AA Neverov, RS Brown Journal of the American Chemical Society 129 (37), 11642-11652, 2007 | 69 | 2007 |
Mechanistic studies of La 3+-and Zn 2+-catalyzed methanolysis of aryl phosphate and phosphorothioate triesters. Development of artificial phosphotriesterase systems T Liu, AA Neverov, JSW Tsang, RS Brown Organic & Biomolecular Chemistry 3 (8), 1525-1533, 2005 | 65 | 2005 |
A Simple DNase Model System Comprising a Dinuclear Zn (II) Complex in Methanol Accelerates the Cleavage of a Series of Methyl Aryl Phosphate Diesters by 1011− 1013 AA Neverov, CT Liu, SE Bunn, D Edwards, CJ White, SA Melnychuk, ... Journal of the American Chemical Society 130 (20), 6639-6649, 2008 | 53 | 2008 |
Protein conformational changes are detected and resolved site specifically by second-harmonic generation B Moree, K Connell, RB Mortensen, CT Liu, SJ Benkovic, J Salafsky Biophysical journal 109 (4), 806-815, 2015 | 52 | 2015 |
Dinuclear Zn (II) catalysts as biomimics of RNA and DNA phosphoryl transfer enzymes: changing the medium from water to alcohol provides enzyme‐like rate enhancements RS Brown, ZL Lu, CT Liu, WY Tsang, DR Edwards, AA Neverov Journal of Physical Organic Chemistry 23 (1), 1-15, 2010 | 47 | 2010 |
Capturing a sulfenic acid with arylboronic acids and benzoxaborole CT Liu, SJ Benkovic Journal of the American Chemical Society 135 (39), 14544-14547, 2013 | 41 | 2013 |
Biomimetic cleavage of RNA models promoted by a dinuclear Zn (II) complex in ethanol. Greater than 30 kcal/mol stabilization of the transition state for cleavage of a phosphate … CT Liu, AA Neverov, RS Brown Journal of the American Chemical Society 130 (49), 16711-16720, 2008 | 39 | 2008 |
Tryptophan-based fluorophores for studying protein conformational changes P Talukder, S Chen, CT Liu, EA Baldwin, SJ Benkovic, SM Hecht Bioorganic & medicinal chemistry 22 (21), 5924-5934, 2014 | 34 | 2014 |
Demonstration of prominent Cu (II)-promoted leaving group stabilization of the cleavage of a homologous set of phosphate mono-, di-, and triesters in methanol CT Liu, AA Neverov, CI Maxwell, RS Brown Journal of the American Chemical Society 132 (10), 3561-3573, 2010 | 34 | 2010 |
Enzyme-like acceleration for the hydrolysis of a DNA model promoted by a dinuclear Zn (II) catalyst in dilute aqueous ethanol CT Liu, AA Neverov, RS Brown Journal of the American Chemical Society 130 (42), 13870-13872, 2008 | 34 | 2008 |
Leaving Group Assistance in the La3+-Catalyzed Cleavage of Dimethyl (o-Methoxycarbonyl)aryl Phosphate Triesters in Methanol DR Edwards, CT Liu, GE Garrett, AA Neverov, RS Brown Journal of the American Chemical Society 131 (38), 13738-13748, 2009 | 33 | 2009 |
Mechanistic and computational study of a palladacycle-catalyzed decomposition of a series of neutral phosphorothioate triesters in methanol CT Liu, CI Maxwell, DR Edwards, AA Neverov, NJ Mosey, RS Brown Journal of the American Chemical Society 132 (46), 16599-16609, 2010 | 30 | 2010 |
Dinuclear Zn (II) complex promotes cleavage and isomerization of 2-hydroxypropyl alkyl phosphates by a common cyclic phosphate intermediate WY Tsang, DR Edwards, SA Melnychuk, CT Liu, C Liu, AA Neverov, ... Journal of the American Chemical Society 131 (11), 4159-4166, 2009 | 29 | 2009 |
A reductionist biomimetic model system that demonstrates highly effective Zn (II)-catalyzed cleavage of an RNA model CT Liu, AA Neverov, RS Brown Inorganic chemistry 46 (5), 1778-1788, 2007 | 25 | 2007 |