Lasse Ebdrup Pedersen
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Multiplex metabolic pathway engineering using CRISPR/Cas9 in Saccharomyces cerevisiae
T Jakočiūnas, I Bonde, M Herrgård, SJ Harrison, M Kristensen, ...
Metabolic engineering 28, 213-222, 2015
Site-specific integration in CHO cells mediated by CRISPR/Cas9 and homology-directed DNA repair pathway
JS Lee, TB Kallehauge, LE Pedersen, HF Kildegaard
Scientific reports 5 (1), 1-11, 2015
CRMAGE: CRISPR optimized mage recombineering
C Ronda, LE Pedersen, MOA Sommer, AT Nielsen
Scientific reports 6 (1), 1-11, 2016
Accelerating genome editing in CHO cells using CRISPR Cas9 and CRISPy, a web‐based target finding tool
C Ronda, LE Pedersen, HG Hansen, TB Kallehauge, MJ Betenbaugh, ...
Biotechnology and bioengineering 111 (8), 1604-1616, 2014
A consensus genome-scale reconstruction of Chinese hamster ovary cell metabolism
H Hefzi, KS Ang, M Hanscho, A Bordbar, D Ruckerbauer, M Lakshmanan, ...
Cell Systems 3 (5), 434-443. e8, 2016
One‐step generation of triple knockout CHO cell lines using CRISPR/Cas9 and fluorescent enrichment
LM Grav, JS Lee, S Gerling, TB Kallehauge, AH Hansen, S Kol, GM Lee, ...
Biotechnology journal 10 (9), 1446-1456, 2015
CRISPy-web: an online resource to design sgRNAs for CRISPR applications
K Blin, LE Pedersen, T Weber, SY Lee
Synthetic and Systems Biotechnology 1 (2), 118-121, 2016
Accelerated homology‐directed targeted integration of transgenes in Chinese hamster ovary cells via CRISPR/Cas9 and fluorescent enrichment
JS Lee, LM Grav, LE Pedersen, GM Lee, HF Kildegaard
Biotechnology and bioengineering 113 (11), 2518-2523, 2016
CasPER, a method for directed evolution in genomic contexts using mutagenesis and CRISPR/Cas9
T Jakočiūnas, LE Pedersen, AV Lis, MK Jensen, JD Keasling
Metabolic engineering 48, 288-296, 2018
Ribosome profiling-guided depletion of an mRNA increases cell growth rate and protein secretion
TB Kallehauge, S Li, LE Pedersen, TK Ha, D Ley, MR Andersen, ...
Scientific reports 7 (1), 1-12, 2017
Multiplex secretome engineering enhances recombinant protein production and purity
S Kol, D Ley, T Wulff, M Decker, J Arnsdorf, S Schoffelen, AH Hansen, ...
Nature communications 11 (1), 1-10, 2020
Elucidation of the CHO super-ome (CHO-SO) by proteoinformatics
A Kumar, D Baycin-Hizal, D Wolozny, LE Pedersen, NE Lewis, K Heffner, ...
Journal of proteome research 14 (11), 4687-4703, 2015
Regulation of cell proliferation and cell density by the inorganic phosphate transporter PiT1
K Byskov, N Jensen, IB Kongsfelt, M Wielsøe, LE Pedersen, C Haldrup, ...
Cell division 7 (1), 1-16, 2012
Awakening dormant glycosyltransferases in CHO cells with CRISPRa
KJC Karottki, H Hefzi, K Xiong, I Shamie, AH Hansen, S Li, LE Pedersen, ...
Biotechnology and bioengineering 117 (2), 593-598, 2020
Genome-wide CRISPRi-based identification of targets for decoupling growth from production
S Li, CB Jendresen, J Landberg, LE Pedersen, N Sonnenschein, ...
ACS Synthetic Biology 9 (5), 1030-1040, 2020
Network reconstruction of the mouse secretory pathway applied on CHO cell transcriptome data
AM Lund, CS Kaas, J Brandl, LE Pedersen, HF Kildegaard, C Kristensen, ...
BMC systems biology 11 (1), 1-17, 2017
Comprehensive analysis of genomic safe harbors as target sites for stable expression of the heterologous gene in HEK293 cells
S Shin, SH Kim, SW Shin, LM Grav, LE Pedersen, JS Lee, GM Lee
ACS Synthetic Biology 9 (6), 1263-1269, 2020
Reprogramming AA catabolism in CHO cells with CRISPR/Cas9 genome editing improves cell growth and reduces byproduct secretion
D Ley, S Pereira, LE Pedersen, J Arnsdorf, H Hefzi, AM Davy, TK Ha, ...
Metabolic engineering 56, 120-129, 2019
Adaptive laboratory evolution reveals general and specific chemical tolerance mechanisms and enhances biochemical production
RM Lennen, K Jensen, ET Mohammed, S Malla, RA Börner, K Chekina, ...
BioRxiv, 634105, 2019
High levels of the type III inorganic phosphate transporter PiT1 (SLC20A1) can confer faster cell adhesion
IB Kongsfelt, K Byskov, LE Pedersen, L Pedersen
Experimental Cell Research 326 (1), 57-67, 2014
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