mTOR-dependent regulation of ribosomal gene transcription requires S6K1 and is mediated by phosphorylation of the carboxy-terminal activation domain of the nucleolar … KM Hannan, Y Brandenburger, A Jenkins, K Sharkey, A Cavanaugh, ... Molecular and cellular biology 23 (23), 8862-8877, 2003 | 573 | 2003 |
Coordinate regulation of ribosome biogenesis and function by the ribosomal protein S6 kinase, a key mediator of mTOR function K Jastrzebski, KM Hannan, EB Tchoubrieva, RD Hannan, RB Pearson Growth factors 25 (4), 209-226, 2007 | 314 | 2007 |
Targeting the nucleolus for cancer intervention JE Quin, JR Devlin, D Cameron, KM Hannan, RB Pearson, RD Hannan Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease 1842 (6), 802-816, 2014 | 276 | 2014 |
AKT induces senescence in human cells via mTORC1 and p53 in the absence of DNA damage: implications for targeting mTOR during malignancy MV Astle, KM Hannan, PY Ng, RS Lee, AJ George, AK Hsu, Y Haupt, ... Oncogene 31 (15), 1949-1962, 2012 | 276 | 2012 |
The nucleolus: an emerging target for cancer therapy N Hein, KM Hannan, AJ George, E Sanij, RD Hannan Trends in molecular medicine 19 (11), 643-654, 2013 | 268 | 2013 |
UBF levels determine the number of active ribosomal RNA genes in mammals E Sanij, G Poortinga, K Sharkey, S Hung, TP Holloway, J Quin, E Robb, ... The Journal of cell biology 183 (7), 1259-1274, 2008 | 243 | 2008 |
MAD1 and c‐MYC regulate UBF and rDNA transcription during granulocyte differentiation G Poortinga, KM Hannan, H Snelling, CR Walkley, A Jenkins, K Sharkey, ... The EMBO journal 23 (16), 3325-3335, 2004 | 210 | 2004 |
Rb and p130 regulate RNA polymerase I transcription: Rb disrupts the interaction between UBF and SL-1 KM Hannan, RD Hannan, SD Smith, LS Jefferson, M Lun, LI Rothblum Oncogene 19 (43), 4988-4999, 2000 | 170 | 2000 |
AKT promotes rRNA synthesis and cooperates with c-MYC to stimulate ribosome biogenesis in cancer JC Chan, KM Hannan, K Riddell, PY Ng, A Peck, RS Lee, S Hung, ... Science signaling 4 (188), ra56-ra56, 2011 | 168 | 2011 |
Transcription by RNA polymerase I KM Hannan, RD Hannan, LI Rothblum Front Biosci 3, d376-d398, 1998 | 154 | 1998 |
Targeting the RNA polymerase I transcription for cancer therapy comes of age R Ferreira, JS Schneekloth Jr, KI Panov, KM Hannan, RD Hannan Cells 9 (2), 266, 2020 | 150 | 2020 |
Dysregulation of RNA polymerase I transcription during disease KM Hannan, E Sanij, LI Rothblum, RD Hannan, RB Pearson Biochimica et Biophysica Acta (BBA)-Gene Regulatory Mechanisms 1829 (3-4 …, 2013 | 146 | 2013 |
Direct identification of tyrosine 474 as a regulatory phosphorylation site for the Akt protein kinase* 210 NM Conus, KM Hannan, BE Cristiano, BA Hemmings, RB Pearson Journal of Biological Chemistry 277 (41), 38021-38028, 2002 | 144 | 2002 |
The nucleolus as a fundamental regulator of the p53 response and a new target for cancer therapy SJ Woods, KM Hannan, RB Pearson, RD Hannan Biochimica et Biophysica Acta (BBA)-Gene Regulatory Mechanisms 1849 (7), 821-829, 2015 | 137 | 2015 |
Combination therapy targeting ribosome biogenesis and mRNA translation synergistically extends survival in MYC-driven lymphoma JR Devlin, KM Hannan, N Hein, C Cullinane, E Kusnadi, PY Ng, ... Cancer discovery 6 (1), 59-70, 2016 | 124 | 2016 |
Translational control of c-MYC by rapamycin promotes terminal myeloid differentiation M Wall, G Poortinga, KM Hannan, RB Pearson, RD Hannan, GA McArthur Blood, The Journal of the American Society of Hematology 112 (6), 2305-2317, 2008 | 121 | 2008 |
A specific role for AKT3 in the genesis of ovarian cancer through modulation of G2-M phase transition BE Cristiano, JC Chan, KM Hannan, NA Lundie, NJ Marmy-Conus, ... Cancer Research 66 (24), 11718-11725, 2006 | 115 | 2006 |
CX-5461 activates the DNA damage response and demonstrates therapeutic efficacy in high-grade serous ovarian cancer E Sanij, KM Hannan, J Xuan, S Yan, JE Ahern, AS Trigos, N Brajanovski, ... Nature communications 11 (1), 2641, 2020 | 114 | 2020 |
RNA polymerase I transcription in confluent cells: Rb downregulates rDNA transcription during confluence-induced cell cycle arrest KM Hannan, BK Kennedy, AH Cavanaugh, RD Hannan, ... Oncogene 19 (31), 3487-3497, 2000 | 110 | 2000 |
Regulation of rDNA transcription in response to growth factors, nutrients and energy EP Kusnadi, KM Hannan, RJ Hicks, RD Hannan, RB Pearson, J Kang Gene 556 (1), 27-34, 2015 | 107 | 2015 |