Piotr Ruchala
Piotr Ruchala
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Mitochondrial dysfunction, through impaired autophagy, leads to endoplasmic reticulum stress, deregulated lipid metabolism, and pancreatitis in animal models
G Biczo, ET Vegh, N Shalbueva, OA Mareninova, J Elperin, E Lotshaw, ...
Gastroenterology 154 (3), 689-703, 2018
Minihepcidins are rationally designed small peptides that mimic hepcidin activity in mice and may be useful for the treatment of iron overload
GC Preza, P Ruchala, R Pinon, E Ramos, B Qiao, MA Peralta, S Sharma, ...
The Journal of clinical investigation 121 (12), 4880-4888, 2011
Minihepcidins prevent iron overload in a hepcidin-deficient mouse model of severe hemochromatosis
E Ramos, P Ruchala, JB Goodnough, L Kautz, GC Preza, E Nemeth, ...
Blood, The Journal of the American Society of Hematology 120 (18), 3829-3836, 2012
Hepcidin-induced hypoferremia is a critical host defense mechanism against the siderophilic bacterium Vibrio vulnificus
J Arezes, G Jung, V Gabayan, E Valore, P Ruchala, PA Gulig, T Ganz, ...
Cell host & microbe 17 (1), 47-57, 2015
Anti-inflammatory apoA-I-mimetic peptides bind oxidized lipids with much higher affinity than human apoA-I
BJ Van Lenten, AC Wagner, CL Jung, P Ruchala, AJ Waring, RI Lehrer, ...
Journal of lipid research 49 (11), 2302-2311, 2008
β-defensin inhibits influenza virus replication by cell-mediated mechanism (s)
M Salvatore, A García-Sastre, P Ruchala, RI Lehrer, T Chang, ...
Journal of Infectious Diseases 196 (6), 835-843, 2007
The pathophysiology and pharmacology of hepcidin
P Ruchala, E Nemeth
Trends in Pharmacological Sciences 35 (3), 155-161, 2014
Interactions of α-, β-, and θ-defensins with influenza A virus and surfactant protein D
M Doss, MR White, T Tecle, D Gantz, EC Crouch, G Jung, P Ruchala, ...
The Journal of Immunology 182 (12), 7878-7887, 2009
Uncovering the mechanism of aggregation of human transthyretin
L Saelices, LM Johnson, WY Liang, MR Sawaya, D Cascio, P Ruchala, ...
Journal of Biological Chemistry 290 (48), 28932-28943, 2015
Roles of Arginine and Lysine Residues in the Translocation of a Cell-Penetrating Peptide from 13C, 31P, and 19F Solid-State NMR
Y Su, T Doherty, AJ Waring, P Ruchala, M Hong
Biochemistry 48 (21), 4587-4595, 2009
Endogenous hepcidin and its agonist mediate resistance to selected infections by clearing non–transferrin-bound iron
D Stefanova, A Raychev, J Arezes, P Ruchala, V Gabayan, M Skurnik, ...
Blood, The Journal of the American Society of Hematology 130 (3), 245-257, 2017
Reawakening retrocyclins: ancestral human defensins active against HIV-1
N Venkataraman, AL Cole, P Ruchala, AJ Waring, RI Lehrer, O Stuchlik, ...
PLoS biology 7 (4), e1000095, 2009
Multivalent binding of carbohydrates by the human α-defensin, HD5
RI Lehrer, G Jung, P Ruchala, S Andre, HJ Gabius, W Lu
The Journal of Immunology 183 (1), 480-490, 2009
Membrane-bound dynamic structure of an arginine-rich cell-penetrating peptide, the protein transduction domain of HIV TAT, from solid-state NMR
Y Su, AJ Waring, P Ruchala, M Hong
Biochemistry 49 (29), 6009-6020, 2010
Lateral stress relaxation and collapse in lipid monolayers
L Pocivavsek, SL Frey, K Krishan, K Gavrilov, P Ruchala, AJ Waring, ...
Soft matter 4 (10), 2019-2029, 2008
Human α-defensins inhibit hemolysis mediated by cholesterol-dependent cytolysins
RI Lehrer, G Jung, P Ruchala, W Wang, ED Micewicz, AJ Waring, ...
Infection and immunity 77 (9), 4028-4040, 2009
A novel method for oral delivery of apolipoprotein mimetic peptides synthesized from all L-amino acids
M Navab, P Ruchala, AJ Waring, RI Lehrer, S Hama, G Hough, ...
Journal of lipid research 50 (8), 1538-1547, 2009
A peptide hairpin inhibitor of amyloid β-protein oligomerization and fibrillogenesis
G Yamin, P Ruchala, DB Teplow
Biochemistry 48 (48), 11329-11331, 2009
Hepcidin protects against lethal Escherichia coli sepsis in mice inoculated with isolates from septic patients
D Stefanova, A Raychev, J Deville, R Humphries, S Campeau, P Ruchala, ...
Infection and Immunity 86 (7), 10.1128/iai. 00253-18, 2018
Critical structural and functional roles for the N-terminal insertion sequence in surfactant protein B analogs
FJ Walther, AJ Waring, JM Hernandez-Juviel, LM Gordon, Z Wang, ...
PLoS One 5 (1), e8672, 2010
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