| Separating transrepression and transactivation: a distressing divorce for the glucocorticoid receptor? R Newton, NS Holden Molecular pharmacology 72 (4), 799-809, 2007 | 400 | 2007 |
| Inhibition of NF-êB-dependent transcription by MKP-1: transcriptional repression by glucocorticoids occurring via p38 MAPK EM King, NS Holden, W Gong, CF Rider, R Newton Journal of Biological Chemistry 284 (39), 26803-26815, 2009 | 159 | 2009 |
| Repression of inflammatory gene expression in human pulmonary epithelial cells by small-molecule IêB kinase inhibitors R Newton, NS Holden, MC Catley, W Oyelusi, R Leigh, D Proud, ... Journal of Pharmacology and Experimental Therapeutics 321 (2), 734-742, 2007 | 139 | 2007 |
| Phorbol ester-stimulated NF-êB-dependent transcription: roles for isoforms of novel protein kinase C NS Holden, PE Squires, M Kaur, R Bland, CE Jones, R Newton Cellular signalling 20 (7), 1338-1348, 2008 | 138 | 2008 |
| IL-1â-dependent activation of NF-êB mediates PGE2 release via the expression of cyclooxygenase-2 and microsomal prostaglandin E synthase MC Catley, JE Chivers, LM Cambridge, N Holden, DM Slater, KJ Staples, ... FEBS letters 547 (1-3), 75-79, 2003 | 136 | 2003 |
| Inhibitors of protein kinase C (PKC) prevent activated transcription: role of events downstream of NF-êB DNA binding MC Catley, LM Cambridge, Y Nasuhara, K Ito, JE Chivers, A Beaton, ... Journal of Biological Chemistry 279 (18), 18457-18466, 2004 | 101 | 2004 |
| Corticosteroid‐induced gene expression in allergen‐challenged asthmatic subjects taking inhaled budesonide MM Kelly, EM King, CF Rider, C Gwozd, NS Holden, J Eddleston, B Zuraw, ... British journal of pharmacology 165 (6), 1737-1747, 2012 | 97 | 2012 |
| â2-Adrenoceptor agonist-induced RGS2 expression is a genomic mechanism of bronchoprotection that is enhanced by glucocorticoids NS Holden, MJ Bell, CF Rider, EM King, DD Gaunt, R Leigh, M Johnson, ... Proceedings of the National Academy of Sciences 108 (49), 19713-19718, 2011 | 97 | 2011 |
| Inhibitors of p38 mitogen-activated protein kinase: potential as anti-inflammatory agents in asthma? R Newton, N Holden BioDrugs 17, 113-129, 2003 | 96 | 2003 |
| Principles and problems of the electrophoretic mobility shift assay NS Holden, CE Tacon Journal of pharmacological and toxicological methods 63 (1), 7-14, 2011 | 91 | 2011 |
| Effect of â2-adrenoceptor agonists and other cAMP-elevating agents on inflammatory gene expression in human ASM cells: a role for protein kinase A M Kaur, NS Holden, SM Wilson, MB Sukkar, KF Chung, PJ Barnes, ... American Journal of Physiology-Lung Cellular and Molecular Physiology 295 (3 …, 2008 | 85 | 2008 |
| Effect of â2-adrenoceptor agonists and other cAMP-elevating agents on inflammatory gene expression in human ASM cells: a role for protein kinase A M Kaur, NS Holden, SM Wilson, MB Sukkar, KF Chung, PJ Barnes, ... American Journal of Physiology-Lung Cellular and Molecular Physiology 295 (3 …, 2008 | 85 | 2008 |
| Analysis of the dissociated steroid RU24858 does not exclude a role for inducible genes in the anti-inflammatory actions of glucocorticoids JE Chivers, W Gong, EM King, J Seybold, JC Mak, LE Donnelly, ... Molecular pharmacology 70 (6), 2084-2095, 2006 | 83 | 2006 |
| Inflammatory stimuli inhibit glucocorticoid-dependent transactivation in human pulmonary epithelial cells: rescue by long-acting â2-adrenoceptor agonists CF Rider, EM King, NS Holden, MA Giembycz, R Newton Journal of Pharmacology and Experimental Therapeutics 338 (3), 860-869, 2011 | 76 | 2011 |
| Human rhinovirus infection up-regulates MMP-9 production in airway epithelial cells via NF-êB CE Tacon, S Wiehler, NS Holden, R Newton, D Proud, R Leigh American journal of respiratory cell and molecular biology 43 (2), 201-209, 2010 | 72 | 2010 |
| ICAM‐1 expression is highly NF‐êB‐dependent in A549 cells: No role for ERK and p38 MAPK NS Holden, MC Catley, LM Cambridge, PJ Barnes, R Newton European journal of biochemistry 271 (4), 785-791, 2004 | 71 | 2004 |
| Efficacy of supervised maintenance exercise following pulmonary rehabilitation on health care use: a systematic review and meta-analysis AR Jenkins, H Gowler, F Curtis, NS Holden, C Bridle, AW Jones International journal of chronic obstructive pulmonary disease, 257-273, 2018 | 70 | 2018 |
| Regulation of tristetraprolin expression by interleukin-1â and dexamethasone in human pulmonary epithelial cells: roles for nuclear factor-êB and p38 mitogen-activated protein … EM King, M Kaur, W Gong, CF Rider, NS Holden, R Newton Journal of Pharmacology and Experimental Therapeutics 330 (2), 575-585, 2009 | 64 | 2009 |
| Validation of IKKâ as therapeutic target in airway inflammatory disease by adenoviral‐mediated delivery of dominant‐negative IKKâ to pulmonary epithelial cells MC Catley, JE Chivers, NS Holden, PJ Barnes, R Newton British journal of pharmacology 145 (1), 114-122, 2005 | 62 | 2005 |
| Induction of regulator of G-protein signaling 2 expression by long-acting â2-adrenoceptor agonists and glucocorticoids in human airway epithelial cells NS Holden, T George, CF Rider, A Chandrasekhar, S Shah, M Kaur, ... Journal of Pharmacology and Experimental Therapeutics 348 (1), 12-24, 2014 | 56 | 2014 |
