| Kinetics for Drug Discovery: an industry-driven effort to target drug residence time DA Schuetz, WEA de Witte, YC Wong, B Knasmueller, L Richter, DB Kokh, ... Drug Discovery Today 22 (6), 896-911, 2017 | 187 | 2017 |
| Development, characterization and application of in situ gel systems for intranasal delivery of tacrine S Qian, YC Wong, Z Zuo International journal of pharmaceutics 468 (1-2), 272-282, 2014 | 117 | 2014 |
| Predicting drug concentration‐time profiles in multiple CNS compartments using a comprehensive physiologically‐based pharmacokinetic model Y Yamamoto, PA Välitalo, DR Huntjens, JH Proost, A Vermeulen, ... CPT: pharmacometrics & systems pharmacology 6 (11), 765-777, 2017 | 77 | 2017 |
| Prediction of human CNS pharmacokinetics using a physiologically-based pharmacokinetic modeling approach Y Yamamoto, PA Välitalo, YC Wong, DR Huntjens, JH Proost, ... European Journal of Pharmaceutical Sciences 112, 168-179, 2018 | 74 | 2018 |
| A generic multi-compartmental CNS distribution model structure for 9 drugs allows prediction of human brain target site concentrations Y Yamamoto, PA Välitalo, DJ van den Berg, R Hartman, W van den Brink, ... Pharmaceutical research 34, 333-351, 2017 | 74 | 2017 |
| Development of a SPE-LC/MS/MS method for simultaneous quantification of baicalein, wogonin, oroxylin A and their glucuronides baicalin, wogonoside and oroxyloside in rats and … SYK Fong, YC Wong, Z Zuo Journal of pharmaceutical and biomedical analysis 97, 9-23, 2014 | 64 | 2014 |
| Intranasal delivery—modification of drug metabolism and brain disposition YC Wong, Z Zuo Pharmaceutical research 27, 1208-1223, 2010 | 55 | 2010 |
| Novel CNS drug discovery and development approach: model-based integration to predict neuro-pharmacokinetics and pharmacodynamics ECM de Lange, W van den Brink, Y Yamamoto, WEA de Witte, YC Wong Expert Opinion on Drug Discovery 12 (12), 1207-1218, 2017 | 51 | 2017 |
| Structure–activity relationships of the glucuronidation of flavonoids by human glucuronosyltransferases YC Wong, L Zhang, G Lin, Z Zuo Expert opinion on drug metabolism & toxicology 5 (11), 1399-1419, 2009 | 49 | 2009 |
| Herb–drug interactions between Scutellariae Radix and mefenamic acid: Simultaneous investigation of pharmacokinetics, anti-inflammatory effect and gastric damage in rats SYK Fong, YC Wong, C Xie, Z Zuo Journal of ethnopharmacology 170, 106-116, 2015 | 41 | 2015 |
| Mechanistic models enable the rational use of in vitro drug-target binding kinetics for better drug effects in patients WEA de Witte, YC Wong, I Nederpelt, LH Heitman, M Danhof, ... Expert opinion on drug discovery 11 (1), 45-63, 2016 | 35 | 2016 |
| Intestinal first-pass glucuronidation activities of selected dihydroxyflavones YC Wong, L Zhang, G Lin, Z Zuo International journal of pharmaceutics 366 (1-2), 14-20, 2009 | 34 | 2009 |
| Brain uptake of bioactive flavones in Scutellariae Radix and its relationship to anxiolytic effect in mice SYK Fong, C Li, YC Ho, R Li, Q Wang, YC Wong, H Xue, Z Zuo Molecular Pharmaceutics 14 (9), 2908-2916, 2017 | 31 | 2017 |
| Brain disposition and catalepsy after intranasal delivery of loxapine: role of metabolism in PK/PD of intranasal CNS drugs YC Wong, Z Zuo Pharmaceutical research 30, 2368-2384, 2013 | 30 | 2013 |
| Investigation of the disposition of loxapine, amoxapine and their hydroxylated metabolites in different brain regions, CSF and plasma of rat by LC–MS/MS YC Wong, SK Wo, Z Zuo Journal of pharmaceutical and biomedical analysis 58, 83-93, 2012 | 26 | 2012 |
| Utility of animal models to understand human Alzheimer’s disease, using the mastermind research approach to avoid unnecessary further sacrifices of animals T Qin, S Prins, GJ Groeneveld, G Van Westen, HE de Vries, YC Wong, ... International journal of molecular sciences 21 (9), 3158, 2020 | 20 | 2020 |
| Intranasal delivery of a novel acetylcholinesterase inhibitor HLS-3 for treatment of Alzheimer's disease S Qian, L He, Q Wang, YC Wong, M Mak, CY Ho, Y Han, Z Zuo Life sciences 207, 428-435, 2018 | 17 | 2018 |
| Regioselective biotransformation of CNS drugs and its clinical impact on adverse drug reactions YC Wong, S Qian, Z Zuo Expert opinion on drug metabolism & toxicology 8 (7), 833-854, 2012 | 14 | 2012 |
| Revealing the neuroendocrine response after remoxipride treatment using multi-biomarker discovery and quantifying it by PK/PD modeling WJ van den Brink, YC Wong, B Gülave, PH van der Graaf, ECM de Lange The AAPS Journal 19, 274-285, 2017 | 13 | 2017 |
| Alterations in the CNS effects of anti-epileptic drugs by Chinese herbal medicines SYK Fong, YC Wong, Z Zuo Expert opinion on drug metabolism & toxicology 10 (2), 249-267, 2014 | 13 | 2014 |
