Activation of PDGF pathway links LMNA mutation to dilated cardiomyopathy J Lee, V Termglinchan, S Diecke, I Itzhaki, CK Lam, P Garg, E Lau, ... Nature 572 (7769), 335-340, 2019 | 160 | 2019 |
Human-induced pluripotent stem cell model of trastuzumab-induced cardiac dysfunction in patients with breast cancer T Kitani, SG Ong, CK Lam, JW Rhee, JZ Zhang, A Oikonomopoulos, N Ma, ... Circulation 139 (21), 2451-2465, 2019 | 159 | 2019 |
Determining the pathogenicity of a genomic variant of uncertain significance using CRISPR/Cas9 and human-induced pluripotent stem cells N Ma, JZ Zhang, I Itzhaki, SL Zhang, H Chen, F Haddad, T Kitani, ... Circulation 138 (23), 2666-2681, 2018 | 128 | 2018 |
A human iPSC double-reporter system enables purification of cardiac lineage subpopulations with distinct function and drug response profiles JZ Zhang, V Termglinchan, NY Shao, I Itzhaki, C Liu, N Ma, L Tian, ... Cell Stem Cell 24 (5), 802-811. e5, 2019 | 119 | 2019 |
Modelling diastolic dysfunction in induced pluripotent stem cell-derived cardiomyocytes from hypertrophic cardiomyopathy patients H Wu, H Yang, JW Rhee, JZ Zhang, CK Lam, K Sallam, ACY Chang, ... European heart journal 40 (45), 3685-3695, 2019 | 109 | 2019 |
Molecular and functional resemblance of differentiated cells derived from isogenic human iPSCs and SCNT-derived ESCs MT Zhao, H Chen, Q Liu, NY Shao, N Sayed, HT Wo, JZ Zhang, SG Ong, ... Proceedings of the National Academy of Sciences 114 (52), E11111-E11120, 2017 | 76 | 2017 |
Clinical trial in a dish using iPSCs shows lovastatin improves endothelial dysfunction and cellular cross-talk in LMNA cardiomyopathy N Sayed, C Liu, M Ameen, F Himmati, JZ Zhang, S Khanamiri, JR Moonen, ... Science translational medicine 12 (554), eaax9276, 2020 | 61 | 2020 |
Comparison of non-human primate versus human induced pluripotent stem cell-derived cardiomyocytes for treatment of myocardial infarction X Zhao, H Chen, D Xiao, H Yang, I Itzhaki, X Qin, T Chour, A Aguirre, ... Stem cell reports 10 (2), 422-435, 2018 | 61 | 2018 |
Single-cell RNA sequencing of human embryonic stem cell differentiation delineates adverse effects of nicotine on embryonic development H Guo, L Tian, JZ Zhang, T Kitani, DT Paik, WH Lee, JC Wu Stem Cell Reports 12 (4), 772-786, 2019 | 54 | 2019 |
Oxidation of RyR2 has a biphasic effect on the threshold for store overload-induced calcium release HMM Waddell, JZ Zhang, KJ Hoeksema, JJ McLachlan, JC McLay, ... Biophysical Journal 110 (11), 2386-2396, 2016 | 31 | 2016 |
DUSP26 induces aortic valve calcification by antagonizing MDM2-mediated ubiquitination of DPP4 in human valvular interstitial cells Y Wang, D Han, T Zhou, C Chen, H Cao, JZ Zhang, N Ma, C Liu, M Song, ... European Heart Journal 42 (30), 2935-2951, 2021 | 27 | 2021 |
Identification of loss-of-function RyR2 mutations associated with idiopathic ventricular fibrillation and sudden death X Zhong, W Guo, J Wei, Y Tang, Y Liu, JZ Zhang, VH Tan, L Zhang, ... Bioscience Reports 41 (4), BSR20210209, 2021 | 27 | 2021 |
Disruption of mesoderm formation during cardiac differentiation due to developmental exposure to 13-cis-retinoic acid Q Liu, K Van Bortle, Y Zhang, MT Zhao, JZ Zhang, BS Geller, JJ Gruber, ... Scientific reports 8 (1), 12960, 2018 | 26 | 2018 |
FKBPs facilitate the termination of spontaneous Ca2+ release in wild-type RyR2 but not CPVT mutant RyR2 JZ Zhang, HMM Waddell, E Wu, J Dholakia, CA Okolo, JC McLay, ... Biochemical Journal 473 (14), 2049-2060, 2016 | 23 | 2016 |
The arrhythmogenic human HRC point mutation S96A leads to spontaneous Ca2+ release due to an impaired ability to buffer store Ca2+ JZ Zhang, JC McLay, PP Jones Journal of molecular and cellular cardiology 74, 22-31, 2014 | 22 | 2014 |
Roles of the NH2-terminal domains of cardiac ryanodine receptor in Ca2+ release activation and termination Y Liu, B Sun, Z Xiao, R Wang, W Guo, JZ Zhang, T Mi, Y Wang, PP Jones, ... Journal of Biological Chemistry 290 (12), 7736-7746, 2015 | 21 | 2015 |
RNA sequencing analysis of induced pluripotent stem cell-derived cardiomyocytes from congenital heart disease patients T Kitani, L Tian, T Zhang, I Itzhaki, JZ Zhang, N Ma, C Liu, JW Rhee, ... Circulation research 126 (7), 923-925, 2020 | 18 | 2020 |
Role of Cys3602 in the function and regulation of the cardiac ryanodine receptor T Mi, Z Xiao, W Guo, Y Tang, F Hiess, J Xiao, Y Wang, JZ Zhang, L Zhang, ... Biochemical Journal 467 (1), 177-190, 2015 | 18 | 2015 |
Regulation of RYR2 by sarcoplasmic reticulum Ca2+ JZ Zhang, HMM Waddell, PP Jones Clinical and Experimental Pharmacology and Physiology 42 (6), 720-726, 2015 | 16 | 2015 |
Protocol to measure contraction, calcium, and action potential in human-induced pluripotent stem cell-derived cardiomyocytes JZ Zhang, SR Zhao, C Tu, P Pang, M Zhang, JC Wu STAR protocols 2 (4), 100859, 2021 | 13 | 2021 |