Amin Rostami-Hodjegan
Amin Rostami-Hodjegan
Professor of Systems Pharmacology, University of Manchester, UK
Verified email at - Homepage
Cited by
Cited by
Simulation and prediction of in vivo drug metabolism in human populations from in vitro data
A Rostami-Hodjegan, GT Tucker
Nature reviews Drug discovery 6 (2), 140-148, 2007
The Simcyp® Population-based ADME Simulator
M Jamei, S Marciniak, K Feng, A Barnett, G Tucker, A Rostami-Hodjegan
Expert opinion on drug metabolism & toxicology 5 (2), 211-223, 2009
Prediction of the clearance of eleven drugs and associated variability in neonates, infants and children
TN Johnson, A Rostami-Hodjegan, GT Tucker
Clinical pharmacokinetics 45, 931-956, 2006
Scaling factors for the extrapolation of in vivo metabolic drug clearance from in vitro data: reaching a consensus on values of human micro-somal protein and hepatocellularity …
ZE Barter, MK Bayliss, PH Beaune, AR Boobis, DJ Carlile, RJ Edwards, ...
Current drug metabolism 8 (1), 33-45, 2007
Population-based mechanistic prediction of oral drug absorption
M Jamei, D Turner, J Yang, S Neuhoff, S Polak, A Rostami-Hodjegan, ...
The AAPS journal 11, 225-237, 2009
The bisphosphonate, zoledronic acid, induces apoptosis of breast cancer cells: evidence for synergy with paclitaxel
SP Jagdev, RE Coleman, CM Shipman, A Rostami-H, PI Croucher
British journal of cancer 84 (8), 1126-1134, 2001
A framework for assessing inter-individual variability in pharmacokinetics using virtual human populations and integrating general knowledge of physical chemistry, biology …
M Jamei, GL Dickinson, A Rostami-Hodjegan
Drug metabolism and pharmacokinetics 24 (1), 53-75, 2009
Anatomical, physiological and metabolic changes with gestational age during normal pregnancy: a database for parameters required in physiologically based pharmacokinetic modelling
K Abduljalil, P Furness, TN Johnson, A Rostami-Hodjegan, H Soltani
Clinical pharmacokinetics 51, 365-396, 2012
Prediction of intestinal first-pass drug metabolism
J Yang, M Jamei, KR Yeo, GT Tucker, A Rostami-Hodjegan
Current drug metabolism 8 (7), 676-684, 2007
Modified-release hydrocortisone to provide circadian cortisol profiles
M Debono, C Ghobadi, A Rostami-Hodjegan, H Huatan, MJ Campbell, ...
The Journal of Clinical Endocrinology & Metabolism 94 (5), 1548-1554, 2009
Changes in liver volume from birth to adulthood: a meta-analysis
TN Johnson, GT Tucker, SM Tanner, A Rostami-Hodjegan
Liver transplantation 11 (12), 1481-1493, 2005
PBPK models for the prediction of in vivo performance of oral dosage forms
ES Kostewicz, L Aarons, M Bergstrand, MB Bolger, A Galetin, O Hatley, ...
European Journal of Pharmaceutical Sciences 57, 300-321, 2014
Physiologically Based Pharmacokinetics Joined With In Vitro–In Vivo Extrapolation of ADME: A Marriage Under the Arch of Systems Pharmacology
A Rostami‐Hodjegan
Clinical Pharmacology & Therapeutics 92 (1), 50-61, 2012
In vivo methods for drug absorption–comparative physiologies, model selection, correlations with in vitro methods (IVIVC), and applications for formulation/API/excipient …
E Sjögren, B Abrahamsson, P Augustijns, D Becker, MB Bolger, ...
European Journal of Pharmaceutical Sciences 57, 99-151, 2014
Influence of dose, cigarette smoking, age, sex, and metabolic activity on plasma clozapine concentrations: a predictive model and nomograms to aid clozapine dose adjustment and …
A Rostami-Hodjegan, AM Amin, EP Spencer, MS Lennard, GT Tucker, ...
Journal of clinical psychopharmacology 24 (1), 70-78, 2004
Weight‐related dosing, timing and monitoring hydrocortisone replacement therapy in patients with adrenal insufficiency
PM Mah, RC Jenkins, A Rostami‐Hodjegan, J Newell‐Price, A Doane, ...
Clinical endocrinology 61 (3), 367-375, 2004
Combining the ‘bottom up’and ‘top down’approaches in pharmacokinetic modelling: fitting PBPK models to observed clinical data
N Tsamandouras, A Rostami‐Hodjegan, L Aarons
British journal of clinical pharmacology 79 (1), 48-55, 2015
Cytochrome p450 turnover: regulation of synthesis and degradation, methods for determining rates, and implications for the prediction of drug interactions
J Yang, M Liao, M Shou, M Jamei, KR Yeo, GT Tucker, ...
Current drug metabolism 9 (5), 384-393, 2008
‘In silico’simulations to assess the ‘in vivo’consequences of ‘in vitro’metabolic drug–drug interactions
A Rostami-Hodjegan, G Tucker
Drug Discovery Today: Technologies 1 (4), 441-448, 2004
Predicting drug clearance from recombinantly expressed CYPs: intersystem extrapolation factors
NJ Proctor, GT Tucker, A Rostami-Hodjegan
Xenobiotica 34 (2), 151-178, 2004
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