The mTOR kinase differentially regulates effector and regulatory T cell lineage commitment GM Delgoffe, TP Kole, Y Zheng, PE Zarek, KL Matthews, B Xiao, ... Immunity 30 (6), 832-844, 2009 | 1396 | 2009 |
The kinase mTOR regulates the differentiation of helper T cells through the selective activation of signaling by mTORC1 and mTORC2 GM Delgoffe, KN Pollizzi, AT Waickman, E Heikamp, DJ Meyers, ... Nature immunology 12 (4), 295-303, 2011 | 1209 | 2011 |
The tumor microenvironment represses T cell mitochondrial biogenesis to drive intratumoral T cell metabolic insufficiency and dysfunction NE Scharping, AV Menk, RS Moreci, RD Whetstone, RE Dadey, ... Immunity 45 (2), 374-388, 2016 | 807 | 2016 |
Bioenergetic insufficiencies due to metabolic alterations regulated by the inhibitory receptor PD-1 are an early driver of CD8+ T cell exhaustion B Bengsch, AL Johnson, M Kurachi, PM Odorizzi, KE Pauken, J Attanasio, ... immunity 45 (2), 358-373, 2016 | 711 | 2016 |
Metabolic support of tumour-infiltrating regulatory T cells by lactic acid MLJ Watson, PDA Vignali, SJ Mullett, AE Overacre-Delgoffe, RM Peralta, ... Nature 591 (7851), 645-651, 2021 | 602 | 2021 |
Stability and function of regulatory T cells is maintained by a neuropilin-1–semaphorin-4a axis GM Delgoffe, SR Woo, ME Turnis, DM Gravano, C Guy, AE Overacre, ... Nature 501 (7466), 252-256, 2013 | 602 | 2013 |
The mammalian target of rapamycin: linking T cell differentiation, function, and metabolism JD Powell, GM Delgoffe Immunity 33 (3), 301-311, 2010 | 546 | 2010 |
Interferon-γ drives Treg fragility to promote anti-tumor immunity AE Overacre-Delgoffe, M Chikina, RE Dadey, H Yano, EA Brunazzi, ... Cell 169 (6), 1130-1141. e11, 2017 | 530 | 2017 |
The composition and signaling of the IL-35 receptor are unconventional LW Collison, GM Delgoffe, CS Guy, KM Vignali, V Chaturvedi, ... Nature immunology 13 (3), 290-299, 2012 | 523 | 2012 |
Efficacy of PD-1 blockade is potentiated by metformin-induced reduction of tumor hypoxia NE Scharping, AV Menk, RD Whetstone, X Zeng, GM Delgoffe Cancer immunology research 5 (1), 9-16, 2017 | 450 | 2017 |
Mitochondrial stress induced by continuous stimulation under hypoxia rapidly drives T cell exhaustion NE Scharping, DB Rivadeneira, AV Menk, PDA Vignali, BR Ford, ... Nature immunology 22 (2), 205-215, 2021 | 425 | 2021 |
mTORC1 and mTORC2 selectively regulate CD8+ T cell differentiation KN Pollizzi, CH Patel, IH Sun, MH Oh, AT Waickman, J Wen, GM Delgoffe, ... The Journal of clinical investigation 125 (5), 2090-2108, 2015 | 411 | 2015 |
Early TCR signaling induces rapid aerobic glycolysis enabling distinct acute T cell effector functions AV Menk, NE Scharping, RS Moreci, X Zeng, C Guy, S Salvatore, H Bae, ... Cell reports 22 (6), 1509-1521, 2018 | 399 | 2018 |
Anergic T cells are metabolically anergic Y Zheng, GM Delgoffe, CF Meyer, W Chan, JD Powell The Journal of Immunology 183 (10), 6095-6101, 2009 | 322 | 2009 |
Metabolic barriers to cancer immunotherapy K DePeaux, GM Delgoffe Nature Reviews Immunology 21 (12), 785-797, 2021 | 298 | 2021 |
Interleukin-35 limits anti-tumor immunity ME Turnis, DV Sawant, AL Szymczak-Workman, LP Andrews, ... Immunity 44 (2), 316-329, 2016 | 291 | 2016 |
Asymmetric inheritance of mTORC1 kinase activity during division dictates CD8+ T cell differentiation KN Pollizzi, IH Sun, CH Patel, YC Lo, MH Oh, AT Waickman, AJ Tam, ... Nature immunology 17 (6), 704-711, 2016 | 246 | 2016 |
CTLA-4 blockade drives loss of Treg stability in glycolysis-low tumours R Zappasodi, I Serganova, IJ Cohen, M Maeda, M Shindo, ... Nature 591 (7851), 652-658, 2021 | 235 | 2021 |
The receptor SIGIRR suppresses Th17 cell proliferation via inhibition of the interleukin-1 receptor pathway and mTOR kinase activation MF Gulen, Z Kang, K Bulek, W Youzhong, TW Kim, Y Chen, CZ Altuntas, ... Immunity 32 (1), 54-66, 2010 | 227 | 2010 |
4-1BB costimulation induces T cell mitochondrial function and biogenesis enabling cancer immunotherapeutic responses AV Menk, NE Scharping, DB Rivadeneira, MJ Calderon, MLJ Watson, ... Journal of experimental medicine 215 (4), 1091-1100, 2018 | 226 | 2018 |