| The myeloma drug lenalidomide promotes the cereblon-dependent destruction of Ikaros proteins G Lu, RE Middleton, H Sun, MV Naniong, CJ Ott, CS Mitsiades, KK Wong, ... Science 343 (6168), 305-309, 2014 | 1443 | 2014 |
| Transformation by the (R)-enantiomer of 2-hydroxyglutarate linked to EGLN activation P Koivunen, S Lee, CG Duncan, G Lopez, G Lu, S Ramkissoon, ... Nature 483 (7390), 484-488, 2012 | 824 | 2012 |
| p38 MAP kinase inhibition enables proliferation of adult mammalian cardiomyocytes FB Engel, M Schebesta, MT Duong, G Lu, S Ren, JB Madwed, H Jiang, ... Genes & development 19 (10), 1175-1187, 2005 | 711 | 2005 |
| A novel cereblon modulator recruits GSPT1 to the CRL4CRBN ubiquitin ligase ME Matyskiela, G Lu, T Ito, B Pagarigan, CC Lu, K Miller, W Fang, ... Nature 535 (7611), 252-257, 2016 | 497 | 2016 |
| A cereblon modulator (CC-220) with improved degradation of Ikaros and Aiolos ME Matyskiela, W Zhang, HW Man, G Muller, G Khambatta, F Baculi, ... Journal of medicinal chemistry 61 (2), 535-542, 2018 | 250 | 2018 |
| SALL4 mediates teratogenicity as a thalidomide-dependent cereblon substrate ME Matyskiela, S Couto, X Zheng, G Lu, J Hui, K Stamp, C Drew, Y Ren, ... Nature chemical biology 14 (10), 981-987, 2018 | 236 | 2018 |
| Protein phosphatase 2Cm is a critical regulator of branched-chain amino acid catabolism in mice and cultured cells G Lu, H Sun, P She, JY Youn, S Warburton, P Ping, TM Vondriska, H Cai, ... The Journal of clinical investigation 119 (6), 1678-1687, 2009 | 212 | 2009 |
| CC-122, a pleiotropic pathway modifier, mimics an interferon response and has antitumor activity in DLBCL PR Hagner, HW Man, C Fontanillo, M Wang, S Couto, M Breider, ... Blood, The Journal of the American Society of Hematology 126 (6), 779-789, 2015 | 190 | 2015 |
| p38 MAP kinase mediates inflammatory cytokine induction in cardiomyocytes and extracellular matrix remodeling in heart M Li, D Georgakopoulos, G Lu, L Hester, DA Kass, J Hasday, Y Wang Circulation 111 (19), 2494-2502, 2005 | 181 | 2005 |
| A novel mitochondrial matrix serine/threonine protein phosphatase regulates the mitochondria permeability transition pore and is essential for cellular survival and development G Lu, S Ren, P Korge, J Choi, Y Dong, J Weiss, C Koehler, J Chen, ... Genes & development 21 (7), 784-796, 2007 | 166 | 2007 |
| Prolyl hydroxylation by EglN2 destabilizes FOXO3a by blocking its interaction with the USP9x deubiquitinase X Zheng, B Zhai, P Koivunen, SJ Shin, G Lu, J Liu, C Geisen, ... Genes & development 28 (13), 1429-1444, 2014 | 136 | 2014 |
| CC-90009, a novel cereblon E3 ligase modulator, targets acute myeloid leukemia blasts and leukemia stem cells C Surka, L Jin, N Mbong, CC Lu, IS Jang, E Rychak, D Mendy, T Clayton, ... Blood, The Journal of the American Society of Hematology 137 (5), 661-677, 2021 | 120 | 2021 |
| TAB-1 modulates intracellular localization of p38 MAP kinase and downstream signaling G Lu, YJ Kang, J Han, HR Herschman, E Stefani, Y Wang Journal of Biological Chemistry 281 (9), 6087-6095, 2006 | 116 | 2006 |
| Functional diversity of mammalian type 2C protein phosphatase isoforms: new tales from an old family G Lu, Y Wang Clinical and Experimental Pharmacology and Physiology 35 (2), 107-112, 2008 | 106 | 2008 |
| Lkb1 inactivation drives lung cancer lineage switching governed by Polycomb Repressive Complex 2 H Zhang, C Fillmore Brainson, S Koyama, AJ Redig, T Chen, S Li, ... Nature communications 8 (1), 14922, 2017 | 105 | 2017 |
| Phosphorylation of ETS1 by Src family kinases prevents its recognition by the COP1 tumor suppressor G Lu, Q Zhang, Y Huang, J Song, R Tomaino, T Ehrenberger, E Lim, ... Cancer cell 26 (2), 222-234, 2014 | 102 | 2014 |
| p97/VCP promotes degradation of CRBN substrate glutamine synthetase and neosubstrates TV Nguyen, J Li, CC Lu, JL Mamrosh, G Lu, BE Cathers, RJ Deshaies Proceedings of the National Academy of Sciences 114 (14), 3565-3571, 2017 | 79 | 2017 |
| CC-90009: a cereblon E3 ligase modulating drug that promotes selective degradation of GSPT1 for the treatment of acute myeloid leukemia JD Hansen, M Correa, M Alexander, M Nagy, D Huang, J Sapienza, G Lu, ... Journal of medicinal chemistry 64 (4), 1835-1843, 2021 | 74 | 2021 |
| Crystal structure of the SALL4–pomalidomide–cereblon–DDB1 complex ME Matyskiela, T Clayton, X Zheng, C Mayne, E Tran, A Carpenter, ... Nature Structural & Molecular Biology 27 (4), 319-322, 2020 | 68 | 2020 |
| Protein Degradation via CRL4CRBN Ubiquitin Ligase: Discovery and Structure–Activity Relationships of Novel Glutarimide Analogs That Promote Degradation of … JD Hansen, K Condroski, M Correa, G Muller, HW Man, A Ruchelman, ... Journal of medicinal chemistry 61 (2), 492-503, 2018 | 68 | 2018 |
