Dr Nathan Brown FRSC
Dr Nathan Brown FRSC
Head of Chemoinformatics at BenevolentAI
Η διεύθυνση ηλεκτρονικού ταχυδρομείου έχει επαληθευτεί στον τομέα benevolent.ai - Αρχική σελίδα
Τίτλος
Παρατίθεται από
Παρατίθεται από
Έτος
Druggability analysis and structural classification of bromodomain acetyl-lysine binding sites
LR Vidler, N Brown, S Knapp, S Hoelder
Journal of medicinal chemistry 55 (17), 7346-7359, 2012
2482012
GuacaMol: benchmarking models for de novo molecular design
N Brown, M Fiscato, MHS Segler, AC Vaucher
Journal of chemical information and modeling 59 (3), 1096-1108, 2019
1672019
A graph-based genetic algorithm and its application to the multiobjective evolution of median molecules
N Brown, B McKay, F Gilardoni, J Gasteiger
Journal of chemical information and computer sciences 44 (3), 1079-1087, 2004
1632004
On scaffolds and hopping in medicinal chemistry
N Brown, E Jacoby
Mini Reviews in Medicinal Chemistry 6 (11), 1217-1229, 2006
1562006
Bioisosteric replacement and scaffold hopping in lead generation and optimization
SR Langdon, P Ertl, N Brown
Molecular Informatics 29 (5), 366-385, 2010
1462010
Discovery of novel small-molecule inhibitors of BRD4 using structure-based virtual screening
LR Vidler, P Filippakopoulos, O Fedorov, S Picaud, S Martin, M Tomsett, ...
Journal of medicinal chemistry 56 (20), 8073-8088, 2013
1222013
Multi-objective optimization methods in drug design
CA Nicolaou, N Brown
Drug Discovery Today: Technologies 10 (3), e427-e435, 2013
1182013
Bioisosteres in medicinal chemistry
N Brown
Wiley. com, 2012
1172012
Scaffold Diversity of Exemplified Medicinal Chemistry Space
SR Langdon, N Brown, J Blagg
Journal of chemical information and modeling, 2011
1142011
Fragment-based hit identification: thinking in 3D
AD Morley, A Pugliese, K Birchall, J Bower, P Brennan, N Brown, ...
Drug Discovery Today 18 (23-24), 1221-1227, 2013
1132013
Molecular optimization using computational multi-objective methods
CA Nicolaou, N Brown, CS Pattichis
Current Opinion in Drug Discovery and Development 10 (3), 316-324, 2007
1052007
Identification of a novel prostate cancer susceptibility variant in the KLK3 gene transcript
Z Kote-Jarai, A Amin Al Olama, D Leongamornlert, M Tymrakiewicz, ...
Human genetics, 1-8, 2011
1042011
Chemoinformatics—an introduction for computer scientists
N Brown
ACM Computing Surveys (CSUR) 41 (2), 1-38, 2009
952009
Relationships between molecular complexity, biological activity, and structural diversity
A Schuffenhauer, N Brown, P Selzer, P Ertl, E Jacoby
Journal of chemical information and modeling 46 (2), 525-535, 2006
862006
Exploring discriminatory features for automated malware classification
G Yan, N Brown, D Kong
International Conference on Detection of Intrusions and Malware, and …, 2013
842013
Plane of best fit: a novel method to characterize the three-dimensionality of molecules
NC Firth, N Brown, J Blagg
Journal of chemical information and modeling 52 (10), 2516-2525, 2012
812012
Optimization of Imidazo[4,5-b]pyridine-Based Kinase Inhibitors: Identification of a Dual FLT3/Aurora Kinase Inhibitor as an Orally Bioavailable Preclinical …
V Bavetsias, S Crumpler, C Sun, S Avery, B Atrash, A Faisal, AS Moore, ...
Journal of medicinal chemistry 55 (20), 8721-8734, 2012
642012
Structural basis of poly (ADP-ribose) recognition by the multizinc binding domain of checkpoint with forkhead-associated and RING Domains (CHFR)
J Oberoi, MW Richards, S Crumpler, N Brown, J Blagg, R Bayliss
Journal of Biological Chemistry 285 (50), 39348-39358, 2010
632010
Party
J Brown, GC Jacobson
Ann Arbor,: University of Michigan., 1970
561970
Aurora Isoform Selectivity: Design and Synthesis of Imidazo[4,5-b]pyridine Derivatives as Highly Selective Inhibitors of Aurora-A Kinase in Cells
V Bavetsias, A Faisal, S Crumpler, N Brown, M Kosmopoulou, A Joshi, ...
Journal of medicinal chemistry 56 (22), 9122-9135, 2013
522013
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