Joshy George
Joshy George
Director, Computational Sciences, Jackson Laboratory for Genomic Medicine, Connecticut
Verified email at
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The Oct4 and Nanog transcription network regulates pluripotency in mouse embryonic stem cells
YH Loh, Q Wu, JL Chew, VB Vega, W Zhang, X Chen, G Bourque, ...
Nature genetics 38 (4), 431-440, 2006
An expression signature for p53 status in human breast cancer predicts mutation status, transcriptional effects, and patient survival
LD Miller, J Smeds, J George, VB Vega, L Vergara, A Ploner, Y Pawitan, ...
Proceedings of the National Academy of Sciences 102 (38), 13550-13555, 2005
Novel molecular subtypes of serous and endometrioid ovarian cancer linked to clinical outcome
RW Tothill, AV Tinker, J George, R Brown, SB Fox, S Lade, DS Johnson, ...
Clinical cancer research 14 (16), 5198-5208, 2008
Whole–genome characterization of chemoresistant ovarian cancer
AM Patch, EL Christie, D Etemadmoghadam, DW Garsed, J George, ...
Nature 521 (7553), 489-494, 2015
BRCA mutation frequency and patterns of treatment response in BRCA mutation–positive women with ovarian cancer: a report from the Australian Ovarian Cancer Study Group
K Alsop, S Fereday, C Meldrum, A DeFazio, C Emmanuel, J George, ...
Journal of Clinical Oncology 30 (21), 2654, 2012
Genetic reclassification of histologic grade delineates new clinical subtypes of breast cancer
AV Ivshina, J George, O Senko, B Mow, TC Putti, J Smeds, T Lindahl, ...
Cancer research 66 (21), 10292-10301, 2006
Pan-cancer analysis of whole genomes
I TCGA-Consortium
Nature 578 (7793), 82-93, 2020
Jmjd1a and Jmjd2c histone H3 Lys 9 demethylases regulate self-renewal in embryonic stem cells
YH Loh, W Zhang, X Chen, J George, HH Ng
Genes & development 21 (20), 2545-2557, 2007
Whole-genome cartography of estrogen receptor α binding sites
CY Lin, VB Vega, JS Thomsen, T Zhang, SL Kong, M Xie, KP Chiu, ...
PLoS genetics 3 (6), e87, 2007
Hormone-receptor expression and ovarian cancer survival: an Ovarian Tumor Tissue Analysis consortium study
W Sieh, M Köbel, TA Longacre, DD Bowtell, A DeFazio, MT Goodman, ...
The lancet oncology 14 (9), 853-862, 2013
The Hippo pathway transcriptional co-activator, YAP, is an ovarian cancer oncogene
X Zhang, J George, S Deb, JL Degoutin, EA Takano, SB Fox, DDL Bowtell, ...
Oncogene 30 (25), 2810-2822, 2011
MicroRNA‐134 modulates the differentiation of mouse embryonic stem cells, where it causes post‐transcriptional attenuation of Nanog and LRH1
YMS Tay, WL Tam, YS Ang, PM Gaughwin, H Yang, W Wang, R Liu, ...
Stem cells 26 (1), 17-29, 2008
Integrated genome-wide DNA copy number and expression analysis identifies distinct mechanisms of primary chemoresistance in ovarian carcinomas
D Etemadmoghadam, A Defazio, R Beroukhim, C Mermel, J George, ...
Clinical cancer research 15 (4), 1417-1427, 2009
Single-cell transcriptomes identify human islet cell signatures and reveal cell-type–specific expression changes in type 2 diabetes
N Lawlor, J George, M Bolisetty, R Kursawe, L Sun, V Sivakamasundari, ...
Genome research 27 (2), 208-222, 2017
Host gene expression profiling of dengue virus infection in cell lines and patients
J Fink, F Gu, L Ling, T Tolfvenstam, F Olfat, KC Chin, P Aw, J George, ...
PLoS neglected tropical diseases 1 (2), e86, 2007
IL6-STAT3-HIF signaling and therapeutic response to the angiogenesis inhibitor sunitinib in ovarian clear cell cancer
MS Anglesio, J George, H Kulbe, M Friedlander, D Rischin, C Lemech, ...
Clinical cancer research 17 (8), 2538-2548, 2011
Genome-wide mapping of RELA (p65) binding identifies E2F1 as a transcriptional activator recruited by NF-κB upon TLR4 activation
CA Lim, F Yao, JJY Wong, J George, H Xu, KP Chiu, WK Sung, L Lipovich, ...
Molecular cell 27 (4), 622-635, 2007
Mesothelial cells promote early ovarian cancer metastasis through fibronectin secretion
HA Kenny, CY Chiang, EA White, EM Schryver, M Habis, IL Romero, ...
The Journal of clinical investigation 124 (10), 4614-4628, 2014
Deregulation of MYCN, LIN28B and LET7 in a Molecular Subtype of Aggressive High-Grade Serous Ovarian Cancers
Ĺ Helland, MS Anglesio, J George, PA Cowin, CN Johnstone, CM House, ...
PloS one 6 (4), e18064, 2011
Synthetic lethality between CCNE1 amplification and loss of BRCA1
D Etemadmoghadam, BA Weir, G Au-Yeung, K Alsop, G Mitchell, ...
Proceedings of the National Academy of Sciences 110 (48), 19489-19494, 2013
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