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Christopher J Tynan
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Hydrophobic fluorescent probes introduce artifacts into single molecule tracking experiments due to non-specific binding
LC Zanetti-Domingues, CJ Tynan, DJ Rolfe, DT Clarke, ...
PloS one 8 (9), e74200, 2013
1992013
A ¡pocket guide¢to total internal reflection fluorescence
ML Martin‐Fernandez, CJ Tynan, SED Webb
Journal of microscopy 252 (1), 16-22, 2013
1782013
EGFR oligomerization organizes kinase-active dimers into competent signalling platforms
SR Needham, SK Roberts, A Arkhipov, VP Mysore, CJ Tynan, ...
Nature communications 7 (1), 13307, 2016
1732016
Focal adhesions are sites of integrin extension
JA Askari, CJ Tynan, SED Webb, ML Martin-Fernandez, C Ballestrem, ...
Journal of cell biology 188 (6), 891-903, 2010
1402010
Candidalysin activates innate epithelial immune responses via epidermal growth factor receptor
J Ho, X Yang, SA Nikou, N Kichik, A Donkin, NO Ponde, JP Richardson, ...
Nature Communications 10 (1), 2297, 2019
1302019
Single-molecule imaging and fluorescence lifetime imaging microscopy show different structures for high-and low-affinity epidermal growth factor receptors in A431 cells
SED Webb, SK Roberts, SR Needham, CJ Tynan, DJ Rolfe, MD Winn, ...
Biophysical journal 94 (3), 803-819, 2008
1102008
The architecture of EGFR¢s basal complexes reveals autoinhibition mechanisms in dimers and oligomers
LC Zanetti-Domingues, D Korovesis, SR Needham, CJ Tynan, S Sagawa, ...
Nature communications 9 (1), 4325, 2018
762018
Automated multidimensional single molecule fluorescence microscopy feature detection and tracking
DJ Rolfe, CI McLachlan, M Hirsch, SR Needham, CJ Tynan, SED Webb, ...
European biophysics journal 40, 1167-1186, 2011
612011
Human epidermal growth factor receptor (EGFR) aligned on the plasma membrane adopts key features of Drosophila EGFR asymmetry
CJ Tynan, SK Roberts, DJ Rolfe, DT Clarke, HH Loeffler, J Kästner, ...
Molecular and cellular biology 31 (11), 2241-2252, 2011
542011
Self-association of calcium-binding protein S100A4 and metastasis
TM Ismail, S Zhang, DG Fernig, S Gross, ML Martin-Fernandez, V See, ...
Journal of biological chemistry 285 (2), 914-922, 2010
542010
3D visualization of additive occlusion and tunable full-spectrum fluorescence in calcite
DC Green, J Ihli, PD Thornton, MA Holden, B Marzec, YY Kim, AN Kulak, ...
Nature communications 7 (1), 13524, 2016
482016
Multicolour single molecule imaging in cells with near infra-red dyes
CJ Tynan, DT Clarke, BC Coles, DJ Rolfe, ML Martin-Fernandez, ...
PloS one 7 (4), e36265, 2012
402012
Structure–function relationships and supramolecular organization of the EGFR (epidermal growth factor receptor) on the cell surface
SR Needham, LC Zanetti-Domingues, M Hirsch, DJ Rolfe, CJ Tynan, ...
Biochemical Society Transactions 42 (1), 114-119, 2014
252014
Optics clustered to output unique solutions: A multi-laser facility for combined single molecule and ensemble microscopy
DT Clarke, SW Botchway, BC Coles, SR Needham, SK Roberts, DJ Rolfe, ...
Review of Scientific Instruments 82 (9), 2011
202011
A tale of the epidermal growth factor receptor: The quest for structural resolution on cells
CJ Tynan, VL Schiavo, L Zanetti-Domingues, SR Needham, SK Roberts, ...
Methods 95, 86-93, 2016
192016
Supramolecular clustering of the cardiac sodium channel Nav1. 5 in HEK293F cells, with and without the auxiliary â3‐subunit
SC Salvage, JS Rees, A McStea, M Hirsch, L Wang, CJ Tynan, MW Reed, ...
The FASEB Journal 34 (3), 3537, 2020
152020
Nanometric molecular separation measurements by single molecule photobleaching
SED Webb, M Hirsch, SR Needham, BC Coles, KM Scherer, SK Roberts, ...
Methods 88, 76-80, 2015
142015
The Rho family GEF FARP2 is activated by aPKCé to control tight junction formation and polarity
A Elbediwy, Y Zhang, M Cobbaut, P Riou, RS Tan, SK Roberts, C Tynan, ...
Journal of Cell Science 132 (8), jcs223743, 2019
132019
Determining the geometry of oligomers of the human epidermal growth factor family on cells with 7 nm resolution
LC Zanetti-Domingues, M Hirsch, CJ Tynan, DJ Rolfe, TV Boyadzhiev, ...
Progress in biophysics and molecular biology 118 (3), 139-152, 2015
122015
Investigating extracellular in situ EGFR structure and conformational changes using FRET microscopy
SK Roberts, CJ Tynan, M Winn, ML Martin-Fernandez
Biochemical Society Transactions 40 (1), 189-194, 2012
122012
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Articles 1–20