| Mitochondrial fusion dynamics is robust in the heart and depends on calcium oscillations and contractile activity V Eisner, RR Cupo, E Gao, G Csordás, WS Slovinsky, M Paillard, ... Proceedings of the National Academy of Sciences 114 (5), E859-E868, 2017 | 147 | 2017 |
| Increased mitochondrial nanotunneling activity, induced by calcium imbalance, affects intermitochondrial matrix exchanges M Lavorato, VR Iyer, W Dewight, RR Cupo, V Debattisti, L Gomez, ... Proceedings of the National Academy of Sciences 114 (5), E849-E858, 2017 | 80 | 2017 |
| Skd3 (human ClpB) is a potent mitochondrial protein disaggregase that is inactivated by 3-methylglutaconic aciduria-linked mutations R Cupo, J Shorter Elife 9 (e55279), 2020 | 57 | 2020 |
| Heterozygous variants of CLPB are a cause of severe congenital neutropenia JT Warren, RR Cupo, P Wattanasirakul, DH Spencer, AE Locke, ... Blood, The Journal of the American Society of Hematology 139 (5), 779-791, 2022 | 28 | 2022 |
| Expression and Purification of Recombinant Skd3 (Human ClpB) Protein and Tobacco Etch Virus (TEV) Protease from Escherichia coli RR Cupo, J Shorter Bio-Protocol 10 (23), 2020 | 11 | 2020 |
| Unique structural features govern the activity of a human mitochondrial AAA+ disaggregase, Skd3 RR Cupo, AN Rizo, GA Braun, E Tse, E Chuang, K Gupta, DR Southworth, ... Cell reports 40 (13), 2022 | 9 | 2022 |
| Tuning Hsp104 specificity to selectively detoxify α-synuclein KL Mack, H Kim, EM Barbieri, JB Lin, S Braganza, ME Jackrel, JE DeNizio, ... Molecular cell 83 (18), 3314-3332. e9, 2023 | 8 | 2023 |
| Opposing roles of p38α-mediated phosphorylation and arginine methylation in driving TDP-43 proteinopathy M Aikio, HJ Wobst, HM Odeh, BL Lee, B Class, TA Ollerhead, KL Mack, ... bioRxiv, 2021.08. 04.455154, 2021 | 6 | 2021 |
| Mitochondrial Dynamics in Neonatal and Adult Cardiomyocytes V Eisner, R Cupo, C Gyorgy, L Cheng, W Koch, G Hajnoczky Biophysical Journal 106 (2), 592a, 2014 | 1 | 2014 |
| Decoding Skd3 (Human CLPB): a Mitochondrial Protein Disaggregase Critical for Human Health RR Cupo, J Shorter Israel Journal of Chemistry, e202300153, 2024 | | 2024 |
| Defining a small-molecule stimulator of the human Hsp70-disaggregase system with selectivity for DnaJB proteins E Chuang, RR Cupo, JR Bevan, ML Rice, S Mao, EL Gorenberg, KL Mack, ... bioRxiv, 2024.01. 11.575109, 2024 | | 2024 |
| Structural and mechanistic studies of Skd3 (human CLPB) provide insight into disease-causing mutations and reveal unique AAA+ oligomerization A Rizo, RR Cupo, J Shorter, DR Southworth Biophysical Journal 121 (3), 325a, 2022 | | 2022 |
| Discovery of a Human Mitochondrial Protein Disaggregase, SKD3 RR Cupo University of Pennsylvania, 2021 | | 2021 |
| Potentiating mutations in Hsp78 rescue neurodegenerative disease toxicity in both the cytoplasm and mitochondria. RR Cupo, E Augustine, J Shorter MOLECULAR BIOLOGY OF THE CELL 29 (26), 2018 | | 2018 |
| Exploring and Enhancing Compartment-Specific Protein Disaggregases to Combat Neurodegenerative Diseases RR Cupo, E Augustine, J Shorter Biophysical Journal 114 (3), 578a-579a, 2018 | | 2018 |
| Exploring compartment-specific protein disaggregases to combat neurodegenerative diseases. RR Cupo, J Shorter MOLECULAR BIOLOGY OF THE CELL 28, 2017 | | 2017 |
| Mitochondrial Fusion Dynamics in the Heart V Eisner, R Cupo, E Gao, G Csordás, L Cheng, J Ibetti, JK Chuprun, ... Biophysical Journal 108 (2), 610a, 2015 | | 2015 |
| HIGH PRESSURE LIQUID CHROMATOGRAPHY DETERMINATION OF ADDITIVES IN RC Chinnif, D Kwasniewski, R Cupo Journal of Undergraduate Chemistry Research 13 (2), 21, 2014 | | 2014 |
| 592a Tuesday, February 18, 2014 V Eisner, R Cupo, C Gyorgy, L Cheng, W Koch, G Hajnoczky | | |
James ShorterProfessor of Biochemistry and Biophysics, University of PennsylvaniaVerified email at pennmedicine.upenn.edu
