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Karl J Staples
Karl J Staples
Professor of Respiratory Immunology & Pharmacology
Verified email at port.ac.uk - Homepage
Title
Cited by
Cited by
Year
Preexisting influenza-specific CD4+ T cells correlate with disease protection against influenza challenge in humans
TM Wilkinson, CKF Li, CSC Chui, AKY Huang, M Perkins, JC Liebner, ...
Nature medicine 18 (2), 274-280, 2012
10312012
Longitudinal profiling of the lung microbiome in the AERIS study demonstrates repeatability of bacterial and eosinophilic COPD exacerbations
D Mayhew, N Devos, C Lambert, JR Brown, SC Clarke, VL Kim, ...
Thorax 73 (5), 422-430, 2018
2502018
Innate and adaptive T cells in asthmatic patients: relationship to severity and disease mechanisms
TSC Hinks, X Zhou, KJ Staples, BD Dimitrov, A Manta, T Petrossian, ...
Journal of allergy and clinical immunology 136 (2), 323-333, 2015
2142015
IL-10 induces IL-10 in primary human monocyte-derived macrophages via the transcription factor Stat3
KJ Staples, T Smallie, LM Williams, A Foey, B Burke, BMJ Foxwell, ...
The Journal of Immunology 178 (8), 4779-4785, 2007
2072007
A prospective, observational cohort study of the seasonal dynamics of airway pathogens in the aetiology of exacerbations in COPD
TMA Wilkinson, E Aris, S Bourne, SC Clarke, M Peeters, TG Pascal, ...
Thorax 72 (10), 919-927, 2017
1782017
A deletion defining a common Asian lineage of Mycobacterium tuberculosis associates with immune subversion
SM Newton, RJ Smith, KA Wilkinson, MP Nicol, NJ Garton, KJ Staples, ...
Proceedings of the National Academy of Sciences 103 (42), 15594-15598, 2006
1432006
Phenotypic characterization of lung macrophages in asthmatic patients: overexpression of CCL17
KJ Staples, TSC Hinks, JA Ward, V Gunn, C Smith, R Djukanović
Journal of Allergy and Clinical Immunology 130 (6), 1404-1412. e7, 2012
1422012
IL‐1â‐dependent activation of NF‐êB mediates PGE2 release via the expression of cyclooxygenase‐2 and microsomal prostaglandin E synthase
MC Catley, JE Chivers, LM Cambridge, N Holden, DM Slater, KJ Staples, ...
FEBS letters 547 (1-3), 75-79, 2003
1362003
Dysregulation of Antiviral Function of CD8+ T Cells in the Chronic Obstructive Pulmonary Disease Lung. Role of the PD-1–PD-L1 Axis
RT McKendry, CM Spalluto, H Burke, B Nicholas, D Cellura, ...
American journal of respiratory and critical care medicine 193 (6), 642-651, 2016
1312016
Chemokine receptor 4 plays a key role in T cell recruitment into the airways of asthmatic patients
P Vijayanand, K Durkin, G Hartmann, J Morjaria, G Seumois, KJ Staples, ...
The Journal of Immunology 184 (8), 4568-4574, 2010
1172010
Relationship between pulmonary matrix metalloproteinases and quantitative CT markers of small airways disease and emphysema in COPD
K Ostridge, N Williams, V Kim, M Bennett, S Harden, L Welch, S Bourne, ...
Thorax 71 (2), 126-132, 2016
1042016
Multitissue transcriptomics delineates the diversity of airway T cell functions in asthma
A Singhania, JC Wallington, CG Smith, D Horowitz, KJ Staples, ...
American journal of respiratory cell and molecular biology 58 (2), 261-270, 2018
972018
Unfractionated heparin inhibits live wild type SARS‐CoV‐2 cell infectivity at therapeutically relevant concentrations
JA Tree, JE Turnbull, KR Buttigieg, MJ Elmore, N Coombes, J Hogwood, ...
British Journal of Pharmacology 178 (3), 626-635, 2021
952021
Seasonality, risk factors and burden of community-acquired pneumonia in COPD patients: a population database study using linked health care records
NP Williams, NA Coombs, MJ Johnson, LK Josephs, LA Rigge, ...
International journal of chronic obstructive pulmonary disease 12, 313, 2017
942017
Steroid-induced deficiency of mucosal-associated invariant T cells in the chronic obstructive pulmonary disease lung. Implications for nontypeable Haemophilus influenzae infection
TSC Hinks, JC Wallington, AP Williams, R Djukanović, KJ Staples, ...
American journal of respiratory and critical care medicine 194 (10), 1208-1218, 2016
942016
Adenosine 3′, 5′-cyclic monophosphate (cAMP)-dependent inhibition of IL-5 from human T lymphocytes is not mediated by the cAMP-dependent protein kinase A
KJ Staples, M Bergmann, K Tomita, MD Houslay, I McPhee, PJ Barnes, ...
The Journal of Immunology 167 (4), 2074-2080, 2001
892001
Impact and associations of eosinophilic inflammation in COPD: analysis of the AERIS cohort
VL Kim, NA Coombs, KJ Staples, KK Ostridge, NP Williams, SA Wootton, ...
European Respiratory Journal 50 (4), 2017
852017
Inflammatory phenotyping predicts clinical outcome in COVID-19
H Burke, A Freeman, DC Cellura, BL Stuart, NJ Brendish, S Poole, ...
Respiratory Research 21 (1), 1-9, 2020
802020
Human CD49a+ lung natural killer cell cytotoxicity in response to influenza A virus
GE Cooper, K Ostridge, SI Khakoo, T Wilkinson, KJ Staples
Frontiers in Immunology 9, 395662, 2018
692018
Role of STAT3 in glucocorticoid-induced expression of the human IL-10 gene
C Unterberger, KJ Staples, T Smallie, L Williams, B Foxwell, A Schaefer, ...
Molecular immunology 45 (11), 3230-3237, 2008
682008
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