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Dharendra Thapa, Ph.D.
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Physiological and structural differences in spatially distinct subpopulations of cardiac mitochondria: influence of cardiac pathologies
JM Hollander, D Thapa, DL Shepherd
American Journal of Physiology-Heart and Circulatory Physiology 307 (1), H1-H14, 2014
1922014
Proteomic alterations of distinct mitochondrial subpopulations in the type 1 diabetic heart: contribution of protein import dysfunction
WA Baseler, ER Dabkowski, CL Williamson, TL Croston, D Thapa, ...
American Journal of Physiology-Regulatory, Integrative and Comparative …, 2011
1542011
miR-141 as a regulator of the mitochondrial phosphate carrier (Slc25a3) in the type 1 diabetic heart
WA Baseler, D Thapa, R Jagannathan, ER Dabkowski, TL Croston, ...
American Journal of Physiology-Cell Physiology 303 (12), C1244-C1251, 2012
1322012
Translational regulation of the mitochondrial genome following redistribution of mitochondrial microRNA in the diabetic heart
R Jagannathan, D Thapa, CE Nichols, DL Shepherd, JC Stricker, ...
Circulation: Cardiovascular Genetics 8 (6), 785-802, 2015
1192015
Functional deficiencies of subsarcolemmal mitochondria in the type 2 diabetic human heart
TL Croston, D Thapa, AA Holden, KJ Tveter, SE Lewis, DL Shepherd, ...
American Journal of Physiology-Heart and Circulatory Physiology 307 (1), H54-H65, 2014
902014
Reversal of mitochondrial proteomic loss in Type 1 diabetic heart with overexpression of phospholipid hydroperoxide glutathione peroxidase
WA Baseler, ER Dabkowski, R Jagannathan, D Thapa, CE Nichols, ...
American Journal of Physiology-Regulatory, Integrative and Comparative …, 2013
882013
Adropin regulates pyruvate dehydrogenase in cardiac cells via a novel GPCR-MAPK-PDK4 signaling pathway
D Thapa, MW Stoner, M Zhang, B Xie, JR Manning, D Guimaraes, S Shiva, ...
Redox biology 18, 25-32, 2018
812018
The protein acetylase GCN5L1 modulates hepatic fatty acid oxidation activity via acetylation of the mitochondrial β-oxidation enzyme HADHA
D Thapa, K Wu, MW Stoner, B Xie, M Zhang, JR Manning, Z Lu, JH Li, ...
Journal of Biological Chemistry 293 (46), 17676-17684, 2018
752018
Acetylation of mitochondrial proteins by GCN5L1 promotes enhanced fatty acid oxidation in the heart
D Thapa, M Zhang, JR Manning, DA Guimarães, MW Stoner, ...
American Journal of Physiology-Heart and Circulatory Physiology 313 (2 …, 2017
732017
Transgenic overexpression of mitofilin attenuates diabetes mellitus-associated cardiac and mitochondria dysfunction
D Thapa, CE Nichols, SE Lewis, DL Shepherd, R Jagannathan, ...
Journal of molecular and cellular cardiology 79, 212-223, 2015
702015
Adropin reduces blood glucose levels in mice by limiting hepatic glucose production
D Thapa, B Xie, JR Manning, M Zhang, MW Stoner, BR Huckestein, ...
Physiological reports 7 (8), e14043, 2019
532019
Adropin treatment restores cardiac glucose oxidation in pre-diabetic obese mice
D Thapa, B Xie, M Zhang, MW Stoner, JR Manning, BR Huckestein, ...
Journal of molecular and cellular cardiology 129, 174-178, 2019
482019
GCN5L1/BLOS1 links acetylation, organelle remodeling, and metabolism
I Scott, L Wang, K Wu, D Thapa, MN Sack
Trends in cell biology 28 (5), 346-355, 2018
472018
Reactive oxygen species damage drives cardiac and mitochondrial dysfunction following acute nano-titanium dioxide inhalation exposure
CE Nichols, DL Shepherd, QA Hathaway, AJ Durr, D Thapa, A Abukabda, ...
Nanotoxicology 12 (1), 32-48, 2018
462018
Early detection of cardiac dysfunction in the type 1 diabetic heart using speckle-tracking based strain imaging
DL Shepherd, CE Nichols, TL Croston, SL McLaughlin, AB Petrone, ...
Journal of molecular and cellular cardiology 90, 74-83, 2016
452016
Cardiac and mitochondrial dysfunction following acute pulmonary exposure to mountaintop removal mining particulate matter
CE Nichols, DL Shepherd, TL Knuckles, D Thapa, JC Stricker, ...
American Journal of Physiology-Heart and Circulatory Physiology 309 (12 …, 2015
452015
Evaluation of the cardiolipin biosynthetic pathway and its interactions in the diabetic heart
TL Croston, DL Shepherd, D Thapa, CE Nichols, SE Lewis, ...
Life sciences 93 (8), 313-322, 2013
452013
Loss of GCN5L1 in cardiac cells disrupts glucose metabolism and promotes cell death via reduced Akt/mTORC2 signaling
JR Manning, D Thapa, M Zhang, MW Stoner, J Traba, C Corey, S Shiva, ...
Biochemical Journal 476 (12), 1713-1724, 2019
242019
Cardiac-specific deletion of GCN5L1 restricts recovery from ischemia-reperfusion injury
JR Manning, D Thapa, M Zhang, MW Stoner, J Traba, CF McTiernan, ...
Journal of molecular and cellular cardiology 129, 69-78, 2019
242019
Rescue of myocardial energetic dysfunction in diabetes through the correction of mitochondrial hyperacetylation by honokiol
M Kerr, JJ Miller, D Thapa, S Stiewe, KN Timm, CNM Aparicio, I Scott, ...
JCI insight 5 (17), 2020
202020
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Articles 1–20