Παρακολούθηση
Fulvio Saccoccia
Fulvio Saccoccia
Institute of Biochemistry and Cell Biology, National Research Council
Η διεύθυνση ηλεκτρονικού ταχυδρομείου έχει επαληθευτεί στον τομέα cnr.it
Τίτλος
Παρατίθεται από
Παρατίθεται από
Έτος
Thioredoxin reductase and its inhibitors
F Saccoccia, F Angelucci, G Boumis, D Carotti, G Desiato, A E Miele, ...
Current Protein and Peptide Science 15 (6), 621-646, 2014
1472014
Crystal structure of the peroxisome proliferator-activated receptor γ (PPARγ) ligand binding domain complexed with a novel partial agonist: a new region of the hydrophobic …
R Montanari, F Saccoccia, E Scotti, M Crestani, C Godio, F Gilardi, ...
Journal of medicinal chemistry 51 (24), 7768-7776, 2008
1262008
Moonlighting by different stressors: crystal structure of the chaperone species of a 2-Cys peroxiredoxin
F Saccoccia, P Di Micco, G Boumis, M Brunori, I Koutris, AE Miele, ...
Structure 20 (3), 429-439, 2012
1242012
Mapping the catalytic cycle of Schistosoma mansoni thioredoxin glutathione reductase by X-ray crystallography
F Angelucci, D Dimastrogiovanni, G Boumis, M Brunori, AE Miele, ...
Journal of biological chemistry 285 (42), 32557-32567, 2010
812010
Switching between the alternative structures and functions of a 2-Cys peroxiredoxin, by site-directed mutagenesis
F Angelucci, F Saccoccia, M Ardini, G Boumis, M Brunori, L Di Leandro, ...
Journal of molecular biology 425 (22), 4556-4568, 2013
642013
On the mechanism and rate of gold incorporation into thiol-dependent flavoreductases
F Saccoccia, F Angelucci, G Boumis, M Brunori, AE Miele, DL Williams, ...
Journal of inorganic biochemistry 108, 105-111, 2012
462012
Typical 2-Cys peroxiredoxins in human parasites: Several physiological roles for a potential chemotherapy target
F Angelucci, AE Miele, M Ardini, G Boumis, F Saccoccia, A Bellelli
Molecular and biochemical parasitology 206 (1-2), 2-12, 2016
352016
Crystal structure of Plasmodium falciparum thioredoxin reductase, a validated drug target
G Boumis, G Giardina, F Angelucci, A Bellelli, M Brunori, ...
Biochemical and biophysical research communications 425 (4), 806-811, 2012
342012
Investigating the antiparasitic potential of the marine sesquiterpene avarone, its reduced form avarol, and the novel semisynthetic thiazinoquinone analogue thiazoavarone
C Imperatore, R Gimmelli, M Persico, M Casertano, A Guidi, F Saccoccia, ...
Marine Drugs 18 (2), 112, 2020
332020
Evolution of the p53-MDM2 pathway
E Åberg, F Saccoccia, M Grabherr, WYJ Ore, P Jemth, G Hultqvist
BMC Evolutionary Biology 17, 1-12, 2017
332017
Discovery by organism based high-throughput screening of new multi-stage compounds affecting Schistosoma mansoni viability, egg formation and production
A Guidi, C Lalli, R Gimmelli, E Nizi, M Andreini, N Gennari, F Saccoccia, ...
PLoS Neglected Tropical Diseases 11 (10), e0005994, 2017
332017
Harnessing the role of HDAC6 in idiopathic pulmonary fibrosis: design, synthesis, structural analysis, and biological evaluation of potent inhibitors
G Campiani, C Cavella, JD Osko, M Brindisi, N Relitti, S Brogi, ...
Journal of medicinal chemistry 64 (14), 9960-9988, 2021
302021
Novel quinolone-based potent and selective HDAC6 inhibitors: Synthesis, molecular modeling studies and biological investigation
N Relitti, AP Saraswati, G Chemi, M Brindisi, S Brogi, D Herp, ...
European Journal of Medicinal Chemistry 212, 112998, 2021
302021
Spiroindoline-capped selective HDAC6 inhibitors: design, synthesis, structural analysis, and biological evaluation
AP Saraswati, N Relitti, M Brindisi, JD Osko, G Chemi, S Federico, A Grillo, ...
ACS Medicinal Chemistry Letters 11 (11), 2268-2276, 2020
302020
Screening and Phenotypical Characterization of Schistosoma mansoni Histone Deacetylase 8 (SmHDAC8) Inhibitors as Multistage Antischistosomal Agents
F Saccoccia, M Brindisi, R Gimmelli, N Relitti, A Guidi, AP Saraswati, ...
ACS Infectious Diseases 6 (1), 100-113, 2019
302019
One ring (or two) to hold them all–on the structure and function of protein nanotubes
F Angelucci, A Bellelli, M Ardini, R Ippoliti, F Saccoccia, V Morea
The FEBS Journal 282 (15), 2827-2845, 2015
252015
Identification of novel multi-stage histone deacetylase (HDAC) inhibitors that impair Schistosoma mansoni viability and egg production
A Guidi, F Saccoccia, N Gennari, R Gimmelli, E Nizi, C Lalli, G Paonessa, ...
Parasites & vectors 11, 1-10, 2018
222018
Azetidin-2-one-based small molecules as dual hHDAC6/HDAC8 inhibitors: Investigation of their mechanism of action and impact of dual inhibition profile on cell viability
S Federico, T Khan, A Fontana, S Brogi, R Benedetti, F Sarno, G Carullo, ...
European Journal of Medicinal Chemistry 238, 114409, 2022
132022
The crystal structure of archaeal serine hydroxymethyltransferase reveals idiosyncratic features likely required to withstand high temperatures
F Angelucci, V Morea, S Angelaccio, F Saccoccia, R Contestabile, A Ilari
Proteins: Structure, Function, and Bioinformatics 82 (12), 3437-3449, 2014
122014
Thiazinoquinones as New Promising Multistage Schistosomicidal Compounds Impacting Schistosoma mansoni and Egg Viability
R Gimmelli, M Persico, C Imperatore, F Saccoccia, A Guidi, M Casertano, ...
ACS Infectious Diseases 6 (1), 124-137, 2019
92019
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