| Association of γ-secretase with lipid rafts in post-Golgi and endosome membranes KS Vetrivel, H Cheng, W Lin, T Sakurai, T Li, N Nukina, PC Wong, H Xu, ... Journal of Biological Chemistry 279 (43), 44945-44954, 2004 | 536 | 2004 |
| Nicastrin is required for assembly of presenilin/γ-secretase complexes to mediate Notch signaling and for processing and trafficking of β-amyloid precursor protein in mammals T Li, G Ma, H Cai, DL Price, PC Wong Journal of Neuroscience 23 (8), 3272-3277, 2003 | 231 | 2003 |
| Accelerated Aβ deposition in APPswe/PS1δE9 mice with hemizygous deletions of TTR (transthyretin) SH Choi, SN Leight, VMY Lee, T Li, PC Wong, JA Johnson, MJ Saraiva, ... Journal of Neuroscience 27 (26), 7006-7010, 2007 | 176 | 2007 |
| CP1 domain in Escherichia coli leucyl-tRNA synthetase is crucial for its editing function JF Chen, NN Guo, T Li, ED Wang, YL Wang Biochemistry 39 (22), 6726-6731, 2000 | 158 | 2000 |
| Glu332 in the nicastrin ectodomain is essential for γ-secretase complex maturation but not for its activity L Chávez-Gutiérrez, A Tolia, E Maes, T Li, PC Wong, B De Strooper Journal of Biological Chemistry 283 (29), 20096-20105, 2008 | 151 | 2008 |
| APH-1a is the principal mammalian APH-1 isoform present in γ-secretase complexes during embryonic development G Ma, T Li, DL Price, PC Wong Journal of Neuroscience 25 (1), 192-198, 2005 | 144 | 2005 |
| Epidermal growth factor receptor and notch pathways participate in the tumor suppressor function of γ-secretase T Li, H Wen, C Brayton, P Das, LA Smithson, A Fauq, X Fan, BJ Crain, ... Journal of Biological Chemistry 282 (44), 32264-32273, 2007 | 110 | 2007 |
| One polypeptide with two aminoacyl-tRNA synthetase activities C Stathopoulos, T Li, R Longman, UC Vothknecht, HD Becker, M Ibba, ... Science 287 (5452), 479-482, 2000 | 110 | 2000 |
| Induced pluripotent stem cells from familial Alzheimer's disease patients differentiate into mature neurons with amyloidogenic properties V Mahairaki, J Ryu, A Peters, Q Chang, T Li, TS Park, PW Burridge, ... Stem cells and development 23 (24), 2996-3010, 2014 | 100 | 2014 |
| Moderate reduction of γ-secretase attenuates amyloid burden and limits mechanism-based liabilities T Li, H Wen, C Brayton, FM Laird, G Ma, S Peng, L Placanica, TC Wu, ... Journal of Neuroscience 27 (40), 10849-10859, 2007 | 92 | 2007 |
| Investigation of the contribution of total creatine to the CEST Z‐spectrum of brain using a knockout mouse model L Chen, H Zeng, X Xu, NN Yadav, S Cai, NA Puts, PB Barker, T Li, ... NMR in biomedicine 30 (12), e3834, 2017 | 89 | 2017 |
| The neuritic plaque facilitates pathological conversion of tau in an Alzheimer’s disease mouse model T Li, KE Braunstein, J Zhang, A Lau, L Sibener, C Deeble, PC Wong Nature communications 7 (1), 12082, 2016 | 86 | 2016 |
| Neutralization of the γ-secretase activity by monoclonal antibody against extracellular domain of nicastrin I Hayashi, S Takatori, Y Urano, Y Miyake, J Takagi, M Sakata-Yanagimoto, ... Oncogene 31 (6), 787-798, 2012 | 86 | 2012 |
| S-palmitoylation of γ-secretase subunits nicastrin and APH-1 H Cheng, KS Vetrivel, RC Drisdel, X Meckler, P Gong, JY Leem, T Li, ... Journal of Biological Chemistry 284 (3), 1373-1384, 2009 | 86 | 2009 |
| Archaeal aminoacyl-tRNA synthesis: diversity replaces dogma D Tumbula, UC Vothknecht, H Kim, M Ibba, B Min, T Li, J Pelaschier, ... Genetics 152 (4), 1269-1276, 1999 | 80 | 1999 |
| Protein aggregation linked to Alzheimer's disease revealed by saturation transfer MRI L Chen, Z Wei, KWY Chan, S Cai, G Liu, H Lu, PC Wong, PCM van Zijl, ... Neuroimage 188, 380-390, 2019 | 76 | 2019 |
| Papillomavirus infection requires γ secretase B Karanam, S Peng, T Li, C Buck, PM Day, RBS Roden Journal of virology 84 (20), 10661-10670, 2010 | 71 | 2010 |
| Alzheimer's therapeutics: translation of preclinical science to clinical drug development AV Savonenko, T Melnikova, A Hiatt, T Li, PF Worley, JC Troncoso, ... Neuropsychopharmacology 37 (1), 261-277, 2012 | 66 | 2012 |
| Cysteinyl-tRNA synthetase is not essential for viability of the archaeon Methanococcus maripaludis C Stathopoulos, W Kim, T Li, I Anderson, B Deutsch, S Palioura, ... Proceedings of the National Academy of Sciences 98 (25), 14292-14297, 2001 | 65 | 2001 |
| Modeling an anti-amyloid combination therapy for Alzheimer’s disease VW Chow, AV Savonenko, T Melnikova, H Kim, DL Price, T Li, PC Wong Science translational medicine 2 (13), 13ra1-13ra1, 2010 | 64 | 2010 |
