| Virtual screening workflow development guided by the “receiver operating characteristic” curve approach. Application to high-throughput docking on metabotropic glutamate … N Triballeau, F Acher, I Brabet, JP Pin, HO Bertrand Journal of medicinal chemistry 48 (7), 2534-2547, 2005 | 673 | 2005 |
| Mapping the Agonist-binding Site of GABAB Type 1 Subunit Sheds Light on the Activation Process of GABABReceptors T Galvez, L Prézeau, G Milioti, M Franek, C Joly, W Froestl, B Bettler, ... Journal of Biological Chemistry 275 (52), 41166-41174, 2000 | 164 | 2000 |
| Excess risk of urinary tract cancers in patients receiving thiopurines for inflammatory bowel disease: a prospective observational cohort study A Bourrier, F Carrat, JF Colombel, AM Bouvier, V Abitbol, P Marteau, ... Alimentary pharmacology & therapeutics 43 (2), 252-261, 2016 | 137 | 2016 |
| Protein–ligand-based pharmacophores: generation and utility assessment in computational ligand profiling J Meslamani, J Li, J Sutter, A Stevens, HO Bertrand, D Rognan Journal of chemical information and modeling 52 (4), 943-955, 2012 | 121 | 2012 |
| Amino acid recognition by Venus flytrap domains is encoded in an 8‐residue motif FC Acher, HO Bertrand Peptide Science: Original Research on Biomolecules 80 (2‐3), 357-366, 2005 | 117 | 2005 |
| Molecular determinants of ligand selectivity in a vertebrate odorant receptor P Luu, F Acher, HO Bertrand, J Fan, J Ngai Journal of Neuroscience 24 (45), 10128-10137, 2004 | 103 | 2004 |
| A novel selective metabotropic glutamate receptor 4 agonist reveals new possibilities for developing subtype selective ligands with therapeutic potential C Goudet, B Vilar, T Courtiol, T Deltheil, T Bessiron, I Brabet, N Oueslati, ... The FASEB Journal 26 (4), 1682-1693, 2012 | 102 | 2012 |
| High risk of anal and rectal cancer in patients with anal and/or perianal Crohn’s disease L Beaugerie, F Carrat, S Nahon, JD Zeitoun, JM Sabaté, L Peyrin-Biroulet, ... Clinical Gastroenterology and Hepatology 16 (6), 892-899. e2, 2018 | 101 | 2018 |
| Common and selective molecular determinants involved in metabotopic glutamate receptor agonist activity HO Bertrand, AS Bessis, JP Pin, FC Acher Journal of medicinal chemistry 45 (15), 3171-3183, 2002 | 95 | 2002 |
| Flexibility of the B-DNA backbone: effects of local and neighbouring sequences on pyrimidine-purine steps HO Bertrand, S Fermandjian, T Ha-Duong, B Hartmann Nucleic acids research 26 (5), 1261-1267, 1998 | 88 | 1998 |
| Cinnabarinic acid, an endogenous metabolite of the kynurenine pathway, activates type 4 metabotropic glutamate receptors F Fazio, L Lionetto, G Molinaro, HO Bertrand, F Acher, RT Ngomba, ... Molecular pharmacology 81 (5), 643-656, 2012 | 84 | 2012 |
| A virtual screening hit reveals new possibilities for developing group III metabotropic glutamate receptor agonists C Selvam, N Oueslati, IA Lemasson, I Brabet, D Rigault, T Courtiol, ... Journal of medicinal chemistry 53 (7), 2797-2813, 2010 | 76 | 2010 |
| Three‐dimensional model of the extracellular domain of the type 4a metabotropic glutamate receptor: New insights into the activation process AS Bessis, F Acher, HO Bertrand, T Galvez, C De Colle, JP Pin Protein science 9 (11), 2200-2209, 2000 | 74 | 2000 |
| Structural basis of NR2B-selective antagonist recognition by N-methyl-D-aspartate receptors L Mony, L Krzaczkowski, M Leonetti, A Le Goff, K Alarcon, J Neyton, ... Molecular pharmacology 75 (1), 60-74, 2009 | 67 | 2009 |
| Synthesis and biological evaluation of 1-amino-2-phosphonomethylcyclopropanecarboxylic acids, new group III metabotropic glutamate receptor agonists P Sibille, S Lopez, I Brabet, O Valenti, N Oueslati, F Gaven, C Goudet, ... Journal of medicinal chemistry 50 (15), 3585-3595, 2007 | 67 | 2007 |
| Predicting fragment binding poses using a combined MCSS MM-GBSA approach MK Haider, HO Bertrand, RE Hubbard Journal of chemical information and modeling 51 (5), 1092-1105, 2011 | 54 | 2011 |
| The effects of aminosalicylates or thiopurines on the risk of colorectal cancer in inflammatory bowel disease F Carrat, P Seksik, JF Colombel, L Peyrin‐Biroulet, L Beaugerie, ... Alimentary pharmacology & therapeutics 45 (4), 533-541, 2017 | 44 | 2017 |
| Allosteric modulation of metabotropic glutamate receptors by chloride ions AS Tora, X Rovira, I Dione, HO Bertrand, I Brabet, Y De Koninck, N Doyon, ... The FASEB Journal 29 (10), 4174-4188, 2015 | 39 | 2015 |
| Sequence effects on energetic and structural properties of phosphorothioate DNA: a molecular modelling study B Hartmann, HO Bertrand, S Fermandjian Nucleic Acids Research 27 (16), 3342-3347, 1999 | 39 | 1999 |
| A critical pocket close to the glutamate binding site of mGlu receptors opens new possibilities for agonist design FC Acher, C Selvam, JP Pin, C Goudet, HO Bertrand Neuropharmacology 60 (1), 102-107, 2011 | 32 | 2011 |
