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Patrick O. Byrne
Patrick O. Byrne
GSK Vaccines Institute for Global Health
Verified email at gsk.com
Title
Cited by
Cited by
Year
Structure-based design of prefusion-stabilized SARS-CoV-2 spikes
CL Hsieh, JA Goldsmith, JM Schaub, AM DiVenere, HC Kuo, ...
Science 369 (6510), 1501-1505, 2020
10282020
EGFR ligands differentially stabilize receptor dimers to specify signaling kinetics
DM Freed, NJ Bessman, A Kiyatkin, E Salazar-Cavazos, PO Byrne, ...
Cell 171 (3), 683-695. e18, 2017
3152017
How IGF-1 activates its receptor
JM Kavran, JM McCabe, PO Byrne, MK Connacher, Z Wang, A Ramek, ...
Elife 3, e03772, 2014
2122014
Expression of Genes in Cyanobacteria: Adaptation of Endogenous Plasmids as Platforms for High-Level Gene Expression in Synechococcus sp. PCC 7002
Y Xu, RM Alvey, PO Byrne, JE Graham, G Shen, DA Bryant
Photosynthesis research protocols, 273-293, 2011
1602011
A single ligand is sufficient to activate EGFR dimers
P Liu, TE Cleveland IV, S Bouyain, PO Byrne, PA Longo, DJ Leahy
Proceedings of the National Academy of Sciences 109 (27), 10861-10866, 2012
1552012
The FRET signatures of noninteracting proteins in membranes: simulations and experiments
C King, S Sarabipour, P Byrne, DJ Leahy, K Hristova
Biophysical journal 106 (6), 1309-1317, 2014
1012014
Expression and characterization of SARS-CoV-2 spike proteins
JM Schaub, CW Chou, HC Kuo, K Javanmardi, CL Hsieh, J Goldsmith, ...
Nature protocols 16 (11), 5339-5356, 2021
382021
EGFR forms ligand-independent oligomers that are distinct from the active state
PO Byrne, K Hristova, DJ Leahy
Journal of Biological Chemistry 295 (38), 13353-13362, 2020
322020
Trimeric SARS-CoV-2 spike proteins produced from CHO cells in bioreactors are high-quality antigens
P Pino, J Kint, D Kiseljak, V Agnolon, G Corradin, AV Kajava, P Rovero, ...
Processes 8 (12), 1539, 2020
222020
Principles and practical applications of structure-based vaccine design
PO Byrne, JS McLellan
Current Opinion in Immunology 77, 102209, 2022
182022
Structure-based Design of Prefusion-stabilized SARS-CoV-2 Spikes. bioRxiv. 2020 May 30: 2020.05. 30.125484. doi: 10.1101/2020.05. 30.125484
CL Hsieh, JA Goldsmith, JM Schaub, AM DiVenere, HC Kuo, ...
Update: Science, 2020
62020
IgG-like bispecific antibodies with potent and synergistic neutralization against circulating SARS-CoV-2 variants of concern
MR Chang, L Tomasovic, NA Kuzmina, AJ Ronk, PO Byrne, R Johnson, ...
Nature communications 13 (1), 5814, 2022
52022
Distinctive features of the respiratory syncytial virus priming loop compared to other non-segmented negative strand RNA viruses
TN Cressey, AM Shareef, VA Kleiner, SL Noton, PO Byrne, JS McLellan, ...
PLoS Pathogens 18 (6), e1010451, 2022
52022
Structural basis for antibody recognition of vulnerable epitopes on Nipah virus F protein
PO Byrne, BE Fisher, DR Ambrozak, EG Blade, Y Tsybovsky, BS Graham, ...
Nature Communications 14 (1), 1494, 2023
42023
Activity of EGFR transmembrane region variants indicates specific transmembrane dimers are not required for EGFR activity
F Bartzoka, M Gonzalez-Magaldi, PO Byrne, NI Callery, K Hristova, ...
Biochemical Journal 479 (24), 2465-2475, 2022
22022
Ligand-independent EGFR oligomers do not rely on the active state asymmetric kinase dimer
PO Byrne, K Hristova, DJ Leahy
bioRxiv, 2020.04. 24.056077, 2020
22020
Prefusion stabilization of the Hendra and Langya virus F proteins
PO Byrne, EG Blade, BE Fisher, DR Ambrozak, AR Ramamohan, ...
Journal of Virology, e01372-23, 2024
12024
Hybrid immunity to SARS-CoV-2 arises from serological recall of IgG antibodies distinctly imprinted by infection or vaccination
WN Voss, MA Mallory, PO Byrne, JM Marchioni, SA Knudson, JM Powers, ...
bioRxiv, 2024.01. 22.576742, 2024
12024
Structural basis for antibody recognition of vulnerable epitopes on Nipah virus F protein
PO Byrne, BE Fisher, DR Ambrozak, EG Blade, Y Tsybovsky, BS Graham, ...
bioRxiv, 2022.06. 13.495706, 2022
12022
Differential and Inducible Expression of Yellow Fluorescent Protein in the Marine Cyanobacterium Synechococcus sp. PCC 7002
PO Byrne
Pennsylvania State University, 2010
12010
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Articles 1–20