Analysis of a 10-ns molecular dynamics simulation of mouse acetylcholinesterase K Tai, T Shen, U Börjesson, M Philippopoulos, JA McCammon
Biophysical journal 81 (2), 715-724, 2001
208 2001 Explicit-solvent molecular dynamics simulation at constant Methodology and application to small amines U Börjesson, PH Hünenberger
The Journal of Chemical Physics 114 (22), 9706-9719, 2001
147 2001 pH-dependent stability of a decalysine α-helix studied by explicit-solvent molecular dynamics simulations at constant pH U Börjesson, PH Hünenberger
The Journal of Physical Chemistry B 108 (35), 13551-13559, 2004
69 2004 Industrial scale high-throughput screening delivers multiple fast acting macrofilaricides RH Clare, C Bardelle, P Harper, WD Hong, U Börjesson, KL Johnston, ...
Nature communications 10 (1), 11, 2019
54 2019 Electrostatic interactions in biomolecular systems PH Hünenberger, U Börjesson, RD Lins
Chimia 55 (10), 861-861, 2001
28 2001 Chemogenetics defines a short-chain fatty acid receptor gut–brain axis N Barki, D Bolognini, U Börjesson, L Jenkins, J Riddell, DI Hughes, ...
Elife 11, e73777, 2022
24 2022 Discovery of AZD8154, a dual PI3Kγδ inhibitor for the treatment of asthma MWD Perry, K Bjorhall, P Bold, M Brulls, U Borjesson, J Carlsson, ...
Journal of Medicinal Chemistry 64 (12), 8053-8075, 2021
24 2021 ProSAR: a new methodology for combinatorial library design H Chen, U Borjesson, O Engkvist, T Kogej, MA Svensson, N Blomberg, ...
Journal of chemical information and modeling 49 (3), 603-614, 2009
20 2009 Fragment-Based Design of a Potent MAT2a Inhibitor and in Vivo Evaluation in an MTAP Null Xenograft Model C De Fusco, M Schimpl, U Börjesson, T Cheung, I Collie, L Evans, ...
Journal of Medicinal Chemistry 64 (10), 6814-6826, 2021
19 2021 Phenotypic high-throughput screening platform identifies novel chemotypes for necroptosis inhibition. H Brito, V Marques, MB Afonso, DG Brown, U Börjesson, N Selmi, ...
Cell Death Discovery 6 (Aricle number: 6(2020)), 2020
16 2020 Structural basis for targeting the folded P-loop conformation of c-MET GW Collie, IN Michaelides, K Embrey, CJ Stubbs, U Börjesson, IL Dale, ...
ACS Medicinal Chemistry Letters 12 (1), 162-167, 2020
12 2020 Effect of mutations involving charged residues on the stability of staphylococcal nuclease: a continuum electrostatics study U Börjesson, PH Hünenberger
Protein engineering 16 (11), 831-840, 2003
11 2003 Fragment-based discovery of novel allosteric MEK1 binders P Di Fruscia, F Edfeldt, I Shamovsky, GW Collie, A Aagaard, L Barlind, ...
ACS Medicinal Chemistry Letters 12 (2), 302-308, 2021
9 2021 Fragment screening at AstraZeneca: developing the next generation biophysics fragment set SCC Lucas, U Börjesson, MJ Bostock, J Cuff, F Edfeldt, KJ Embrey, ...
RSC Medicinal Chemistry 13 (9), 1052-1057, 2022
8 2022 Discovery and optimization of the first ATP competitive type-III c-MET inhibitor IN Michaelides, GW Collie, U Börjesson, C Vasalou, O Alkhatib, ...
Journal of Medicinal Chemistry 66 (13), 8782-8807, 2023
5 2023 Discovery of a selective c-MET inhibitor with a novel binding mode GW Collie, L Barlind, S Bazzaz, U Börjesson, IL Dale, JS Disch, ...
Bioorganic & Medicinal Chemistry Letters 75, 128948, 2022
5 2022 5-[2-(pyridin-2-ylamino)-1, 3-thiazol-5-yl]-2, 3-dihydro-1 h-isoindol-1-one derivatives and their use as dual inhibitors of phosphatidylinositol 3-kinase delta & gamma M Perry, K Karabelas, M Mogemark, P Bold, C Tyrchan, A Nikitidis, ...
4 2018 Surprising lipophilicity observations identify unexpected conformational effects MWD Perry, U Börjesson, A Nikitidis, C Tyrchan
Bioorganic & Medicinal Chemistry Letters 69, 128786, 2022
1 2022 Chemogenetic analysis of how receptors for short chain fatty acids regulate the gut-brain axis N Barki, D Bolognini, U Börjesson, L Jenkins, J Riddell, DI Hughes, ...
bioRxiv, 2020.01. 11.902726, 2020
1 2020 Chemogenomics in Drug Discovery. Methods and Principles in Medicinal Chemistry, Vol. 22. Edited by Hugo Kubinyi and Gerhard Müller. U Börjesson
Angewandte Chemie International Edition 44 (19), 2832-2832, 2005
1 2005