| Genetic patterns in head and neck cancers that contain or lack transcriptionally active human papillomavirus BJM Braakhuis, PJF Snijders, WJH Keune, CJLM Meijer, ... Journal of the national cancer institute 96 (13), 998-1006, 2004 | 508 | 2004 |
| Nuclear PtdIns5P as a transducer of stress signaling: an in vivo role for PIP4Kbeta DR Jones, Y Bultsma, WJ Keune, JR Halstead, D Elouarrat, S Mohammed, ... Molecular cell 23 (5), 685-695, 2006 | 219 | 2006 |
| PIP4Kβ interacts with and modulates nuclear localization of the high-activity PtdIns5P-4-kinase isoform PIP4Kα Y Bultsma, WJ Keune, N Divecha Biochemical Journal 430 (2), 223-235, 2010 | 104 | 2010 |
| Steroid binding to Autotaxin links bile salts and lysophosphatidic acid signalling WJ Keune, J Hausmann, R Bolier, D Tolenaars, A Kremer, T Heidebrecht, ... Nature communications 7 (1), 11248, 2016 | 86 | 2016 |
| PIP4K and the role of nuclear phosphoinositides in tumour suppression R Fiume, Y Stijf-Bultsma, ZH Shah, WJ Keune, DR Jones, JG Jude, ... Biochimica et Biophysica Acta (BBA)-Molecular and Cell Biology of Lipids …, 2015 | 58 | 2015 |
| PtdIns5P is an oxidative stress‐induced second messenger that regulates PKB activation DR Jones, R Foulger, WJ Keune, Y Bultsma, N Divecha The FASEB Journal 27 (4), 1644-1656, 2013 | 57 | 2013 |
| Phosphoinositide signalling in the nucleus W jan Keune, Y Bultsma, L Sommer, D Jones, N Divecha Advances in enzyme regulation 51 (1), 91-99, 2011 | 54 | 2011 |
| Rac controls PIP5K localisation and PtdIns(4,5)P2 synthesis, which modulates vinculin localisation and neurite dynamics JR Halstead, NE Savaskan, I Van Den Bout, F Van Horck, ... Journal of cell science 123 (20), 3535-3546, 2010 | 53 | 2010 |
| Regulation of phosphatidylinositol-5-phosphate signaling by Pin1 determines sensitivity to oxidative stress WJ Keune, DR Jones, Y Bultsma, L Sommer, XZ Zhou, KP Lu, N Divecha Science signaling 5 (252), ra86-ra86, 2012 | 50 | 2012 |
| Nuclear phosphoinositides: location, regulation and function R Fiume, WJ Keune, I Faenza, Y Bultsma, G Ramazzotti, DR Jones, ... Phosphoinositides II: The Diverse Biological Functions, 335-361, 2012 | 44 | 2012 |
| Low PIP4K2B expression in human breast tumors correlates with reduced patient survival: a role for PIP4K2B in the regulation of E-cadherin expression WJ Keune, AH Sims, DR Jones, Y Bultsma, JT Lynch, K Jirström, ... Cancer research 73 (23), 6913-6925, 2013 | 42 | 2013 |
| Rational design of autotaxin inhibitors by structural evolution of endogenous modulators WJ Keune, F Potjewyd, T Heidebrecht, F Salgado-Polo, SJF Macdonald, ... Journal of medicinal chemistry 60 (5), 2006-2017, 2017 | 40 | 2017 |
| Structure–activity relationships of small molecule autotaxin inhibitors with a discrete binding mode LM Miller, WJ Keune, D Castagna, LC Young, EL Duffy, F Potjewyd, ... Journal of Medicinal Chemistry 60 (2), 722-748, 2017 | 40 | 2017 |
| PtdIns5P and Pin1 in oxidative stress signaling WJ Keune, DR Jones, N Divecha Advances in biological regulation 53 (2), 179-189, 2013 | 39 | 2013 |
| Lysophosphatidic acid produced by autotaxin acts as an allosteric modulator of its catalytic efficiency F Salgado-Polo, A Fish, MT Matsoukas, T Heidebrecht, WJ Keune, ... Journal of Biological Chemistry 293 (37), 14312-14327, 2018 | 33 | 2018 |
| The hexosamine biosynthesis pathway and O‐Glc NA cylation maintain insulin‐stimulated PI 3K‐PKB phosphorylation and tumour cell growth after short‐term glucose deprivation DR Jones, WJ Keune, KE Anderson, LR Stephens, PT Hawkins, ... The FEBS journal 281 (16), 3591-3608, 2014 | 32 | 2014 |
| The tumor suppressor LKB1 regulates starvation-induced autophagy under systemic metabolic stress LA Mans, L Querol Cano, J van Pelt, P Giardoglou, WJ Keune, ... Scientific reports 7 (1), 7327, 2017 | 30 | 2017 |
| Structural snapshots of the catalytic cycle of the phosphodiesterase Autotaxin J Hausmann, WJ Keune, ALH Ederveen, L van Zeijl, RP Joosten, ... Journal of structural biology 195 (2), 199-206, 2016 | 19 | 2016 |
| Collaboration of AMPK and PKC to induce phosphorylation of Ser413 on PIP5K1B resulting in decreased kinase activity and reduced PtdIns(4,5)P2 synthesis in … I Van den Bout, DR Jones, ZH Shah, JR Halstead, WJ Keune, ... Biochemical Journal 455 (3), 347-358, 2013 | 13 | 2013 |
| Methods for the Determination of the Mass of Nuclear PtdIns4P, PtdIns5P, and PtdIns(4,5)P 2 DR Jones, Y Bultsma, WJ Keune, N Divecha Lipid Signaling Protocols, 1-14, 2009 | 10 | 2009 |
