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Phillip C. Delekta, Ph.D.
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Year
Discovery of potent broad spectrum antivirals derived from marine actinobacteria
A Raveh, PC Delekta, CJ Dobry, W Peng, PJ Schultz, PK Blakely, AW Tai, ...
PloS one 8 (12), e82318, 2013
1092013
Thrombin-dependent NF-κB activation and monocyte/endothelial adhesion are mediated by the CARMA3· Bcl10· MALT1 signalosome
PC Delekta, IJ Apel, S Gu, K Siu, Y Hattori, LM McAllister-Lucas, ...
Journal of Biological Chemistry 285 (53), 41432-41442, 2010
972010
The CARMA3-Bcl10-MALT1 signalosome promotes angiotensin II-dependent vascular inflammation and atherogenesis
LM McAllister-Lucas, X Jin, S Gu, K Siu, S McDonnell, J Ruland, ...
Journal of biological chemistry 285 (34), 25880-25884, 2010
882010
The CARMA3–Bcl10–MALT1 Signalosome Drives NFκB Activation and Promotes Aggressiveness in Angiotensin II Receptor–Positive Breast Cancer
P Ekambaram, JY Lee, NE Hubel, D Hu, S Yerneni, PG Campbell, ...
Cancer research 78 (5), 1225-1240, 2018
732018
Staphylococcus aureus utilizes host-derived lipoprotein particles as sources of fatty acids
PC Delekta, JC Shook, TA Lydic, MH Mulks, ND Hammer
Journal of bacteriology 200 (11), 10.1128/jb. 00728-17, 2018
592018
Bcl10 links saturated fat overnutrition with hepatocellular NF-κB activation and insulin resistance
M Van Beek, KI Oravecz-Wilson, PC Delekta, S Gu, X Li, X Jin, IJ Apel, ...
Cell reports 1 (5), 444-452, 2012
512012
MALT1 protease activation triggers acute disruption of endothelial barrier integrity via CYLD cleavage
LR Klei, D Hu, R Panek, DN Alfano, RE Bridwell, KM Bailey, ...
Cell reports 17 (1), 221-232, 2016
422016
Marek’s disease virus immunosuppression alters host cellular responses and immune gene expression in the skin of infected chickens
M Heidaria, D Wang, P Delekta, S Sun
Veterinary Immunology and Immunopathology 180, 21-28, 2016
232016
The Staphylococcus aureus cystine transporters TcyABC and TcyP facilitate nutrient sulfur acquisition during infection
JM Lensmire, JP Dodson, BY Hsueh, MR Wischer, PC Delekta, JC Shook, ...
Infection and Immunity 88 (3), 10.1128/iai. 00690-19, 2020
222020
Transcriptomic analysis of host immune response in the skin of chickens infected with Marek's disease virus
M Heidari, PC Delekta
Viral immunology 30 (5), 377-387, 2017
212017
Widely Applicable PCR Markers for Sex Identification in Birds
RA Romanov, M. N. Betuel, A. M. Chemnick, L. G. Ryder, O. A. Kulibaba, R. O ...
Russian Journal of Genetics 55 (2), 220-231, 2019
202019
Novel indole-2-carboxamide compounds are potent broad-spectrum antivirals active against western equine encephalitis virus in vivo
PC Delekta, CJ Dobry, JA Sindac, SJ Barraza, PK Blakely, J Xiang, ...
Journal of Virology 88 (19), 11199-11214, 2014
162014
GRK2 suppresses lymphomagenesis by inhibiting the MALT1 proto-oncoprotein
J Cheng, LR Klei, NE Hubel, M Zhang, R Schairer, LM Maurer, HB Klei, ...
The Journal of clinical investigation 130 (2), 1036-1051, 2020
152020
Discovery of anthranilamides as a novel class of inhibitors of neurotropic alphavirus replication
SJ Barraza, PC Delekta, JA Sindac, CJ Dobry, J Xiang, RF Keep, ...
Bioorganic & Medicinal Chemistry 23 (7), 1569-1587, 2015
152015
Manipulation of host factors optimizes the pathogenesis of western equine encephalitis virus infections in mice for antiviral drug development
PK Blakely, PC Delekta, DJ Miller, DN Irani
Journal of Neurovirology 21 (1), 43-55, 2015
82015
The glutathione import system satisfies the Staphylococcus aureus nutrient sulfur requirement and promotes interspecies competition
JM Lensmire, MR Wischer, C Kraemer-Zimpel, PJ Kies, L Sosinski, ...
PLoS Genetics 19 (7), e1010834, 2023
72023
The combined use of alphavirus replicons and pseudoinfectious particles for the discovery of antivirals derived from natural products
PC Delekta, A Raveh, MJ Larsen, PJ Schultz, G Tamayo-Castillo, ...
Journal of Biomolecular Screening 20 (5), 673-680, 2015
72015
Synthesis and biological activity of conformationally restricted indole-based inhibitors of neurotropic alphavirus replication: Generation of a three-dimensional pharmacophore
SJ Barraza, JA Sindac, CJ Dobry, PC Delekta, PH Lee, DJ Miller, ...
Bioorganic & medicinal chemistry letters 46, 128171, 2021
32021
Isolation of lipoprotein particles from chicken egg yolk for the study of bacterial pathogen fatty acid incorporation into membrane phospholipids
PC Delekta, TA Lydic, ND Hammer
JoVE (Journal of Visualized Experiments), e59538, 2019
22019
GPCR-dependent NF-κB Signaling in Endothelial Dysfunction: A Critical Role for the CARMA3/Bcl10/MALT1 Signaling Complex
PC Delekta
University of Michigan, 2011
12011
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Articles 1–20