Primordial‐like enzymes from bacteria with reduced genomes MP Ferla, JL Brewster, KR Hall, GB Evans, WM Patrick Molecular Microbiology 105 (4), 508-524, 2017 | 34 | 2017 |
NTR 2.0: a rationally engineered prodrug-converting enzyme with substantially enhanced efficacy for targeted cell ablation AV Sharrock, TS Mulligan, KR Hall, EM Williams, DT White, L Zhang, ... Nature methods 19 (2), 205-215, 2022 | 33 | 2022 |
Large-scale phenotypic drug screen identifies neuroprotectants in zebrafish and mouse models of retinitis pigmentosa L Zhang, C Chen, J Fu, B Lilley, C Berlinicke, B Hansen, D Ding, G Wang, ... Elife 10, e57245, 2021 | 15 | 2021 |
Reductants fuel lytic polysaccharide monooxygenase activity in a pH‐dependent manner O Golten, I Ayuso‐Fernández, KR Hall, AA Stepnov, M Sørlie, ÅK Røhr, ... FEBS letters 597 (10), 1363-1374, 2023 | 13 | 2023 |
Evaluation of NfsA-like nitroreductases from Neisseria meningitidis and Bartonella henselae for enzyme-prodrug therapy, targeted cellular ablation, and … MH Rich, AV Sharrock, KR Hall, DF Ackerley, JK MacKichan Biotechnology letters 40, 359-367, 2018 | 11 | 2018 |
Intracellular complexities of acquiring a new enzymatic function revealed by mass-randomisation of active-site residues KR Hall, KJ Robins, EM Williams, MH Rich, MJ Calcott, JN Copp, RF Little, ... Elife 9, e59081, 2020 | 8* | 2020 |
Total Synthesis and Bioactivity Studies of Fungal Metabolite (−)-TAN-2483B JAJ McCone, KK Somarathne, CL Orme, RJ Hewitt, ER Grant, KR Hall, ... Organic Letters 22 (24), 9427-9432, 2020 | 7 | 2020 |
A conserved second sphere residue tunes copper site reactivity in lytic polysaccharide monooxygenases KR Hall, C Joseph, I Ayuso-Fernández, A Tamhankar, L Rieder, R Skaali, ... Journal of the American Chemical Society 145 (34), 18888-18903, 2023 | 5 | 2023 |
Mutational dissection of a hole hopping route that can be tuned to boost peroxygenase activity in LPMOs VGH Eijsink, I Ayuso-Fernández, TZ Emrich-Mills, J Haak, O Golten, ... | | 2023 |
LPMO immobilization on Carbon nanotubes: a first investigation toward higher stability and catalytic activity C Pontremoli, K Hall, M Bonomo, N Barbero, C Barolo, M Sørlie, V Eijsink, ... -, 60-60, 2023 | | 2023 |
Investigating the evolvability of'Escherichia coli nfsA'via simultaneous site-directed mutagenesis K Hall Open Access Te Herenga Waka-Victoria University of Wellington, 2019 | | 2019 |
Using E. coli NfsA as a model to improve our understanding of enzyme engineering KR Hall, K Robins, W Patrick, D Ackerley, A Sharrock, J Mumm | | 2019 |
Engineering bacterial nitroreductases for anticancer gene therapy and targeted cell ablation A Sharrock, E Williams, V Arcus, J Mumm, D Ackerley | | 2017 |
Simultaneous randomisation of eight key active site residues in E. coli NfsA to generate superior nitroreductases for prodrug activation KR Hall, K Robins, D Ackerley, M Rich, R Little, J Copp, A Sharrock, ... | | 2017 |