| The crystal structure of a phosphorylase kinase peptide substrate complex: kinase substrate recognition ED Lowe, MEM Noble, VT Skamnaki, NG Oikonomakos, DJ Owen, ... The EMBO journal, 1997 | 275 | 1997 |
| A new allosteric site in glycogen phosphorylase b as a target for drug interactions NG Oikonomakos, VT Skamnaki, KE Tsitsanou, NG Gavalas, LN Johnson Structure 8 (6), 575-584, 2000 | 184 | 2000 |
| Flavopiridol inhibits glycogen phosphorylase by binding at the inhibitor site NG Oikonomakos, JB Schnier, SE Zographos, VT Skamnaki, ... Journal of Biological Chemistry 275 (44), 34566-34573, 2000 | 171 | 2000 |
| The structure of cyclin E1/CDK2: implications for CDK2 activation and CDK2‐independent roles R Honda, ED Lowe, E Dubinina, V Skamnaki, A Cook, NR Brown, ... The EMBO journal 24 (3), 452-463, 2005 | 166 | 2005 |
| The role of the phospho-CDK2/cyclin A recruitment site in substrate recognition KY Cheng, MEM Noble, V Skamnaki, NR Brown, ED Lowe, ... Journal of biological chemistry 281 (32), 23167-23179, 2006 | 113 | 2006 |
| The structure of glycogen phosphorylase b with an alkyldihydropyridine-dicarboxylic acid compound, a novel and potent inhibitor SE Zographos, NG Oikonomakos, KE Tsitsanou, DD Leonidas, ... Structure 5 (11), 1413-1425, 1997 | 112 | 1997 |
| Catalytic Mechanism of Phosphorylase Kinase Probed by Mutational Studies, VT Skamnaki, DJ Owen, MEM Noble, ED Lowe, G Lowe, ... Biochemistry 38 (44), 14718-14730, 1999 | 110 | 1999 |
| Kinetics, in silico docking, molecular dynamics, and MM‐GBSA binding studies on prototype indirubins, KT5720, and staurosporine as phosphorylase kinase ATP … JM Hayes, VT Skamnaki, G Archontis, C Lamprakis, J Sarrou, N Bischler, ... Proteins: Structure, Function, and Bioinformatics 79 (3), 703-719, 2011 | 108 | 2011 |
| Cyclin B and cyclin A confer different substrate recognition properties on CDK2 NR Brown, ED Lowe, E Petri, V Skamnaki, R Antrobus, L Johnson Cell Cycle 6 (11), 1350-1359, 2007 | 101 | 2007 |
| Allosteric inhibition of glycogen phosphorylase a by the potential antidiabetic drug 3-isopropyl 4-(2-chlorophenyl)-1, 4-dihydro-1-ethyl-2-methyl-pyridine-3, 5, 6-tricarboxylate NG Oikonomakos, KE Tsitsanou, SE Zographos, VT Skamnaki, ... Protein Science 8 (10), 1930-1945, 1999 | 77 | 1999 |
| Cooperative Interactions of the Catalytic Nucleophile and the Catalytic Acid in the Inhibition of â‐Glycosidases. Calculations and their validation by comparative kinetic and … TD Heightman, A Vasella, KE Tsitsanou, SE Zographos, VT Skamnaki, ... Helvetica chimica acta 81 (5‐8), 853-864, 1998 | 74 | 1998 |
| Kinetic and crystallographic studies of glucopyranosylidene spirothiohydantoin binding to glycogen phosphorylase b NG Oikonomakos, VT Skamnaki, E Ösz, L Szilágyi, L Somsák, T Docsa, ... Bioorganic & medicinal chemistry 10 (2), 261-268, 2002 | 73 | 2002 |
| 1-(3-Deoxy-3-fluoro-â-D-glucopyranosyl) pyrimidine derivatives as inhibitors of glycogen phosphorylase b: Kinetic, crystallographic and modelling studies VG Tsirkone, E Tsoukala, C Lamprakis, S Manta, JM Hayes, VT Skamnaki, ... Bioorganic & medicinal chemistry 18 (10), 3413-3425, 2010 | 69 | 2010 |
| Structural Studies on Phospho-CDK2/Cyclin A Bound to Nitrate, a Transition State Analogue: Implications for the Protein Kinase Mechanism, A Cook, ED Lowe, ED Chrysina, VT Skamnaki, NG Oikonomakos, ... Biochemistry 41 (23), 7301-7311, 2002 | 66 | 2002 |
| Natural flavonoids as antidiabetic agents. The binding of gallic and ellagic acids to glycogen phosphorylase b E Kyriakis, GA Stravodimos, AL Kantsadi, DSM Chatzileontiadou, ... FEBS letters 589 (15), 1787-1794, 2015 | 63 | 2015 |
| The ó‐Hole Phenomenon of Halogen Atoms Forms the Structural Basis of the Strong Inhibitory Potency of C5 Halogen Substituted Glucopyranosyl Nucleosides towards Glycogen … AL Kantsadi, JM Hayes, S Manta, VT Skamnaki, C Kiritsis, AMG Psarra, ... ChemMedChem 7 (4), 722-732, 2012 | 62 | 2012 |
| Biochemical and biological assessment of the inhibitory potency of extracts from vinification byproducts of Vitis vinifera extracts against glycogen phosphorylase AL Kantsadi, A Apostolou, S Theofanous, GA Stravodimos, E Kyriakis, ... Food and chemical toxicology 67, 35-43, 2014 | 58 | 2014 |
| The 1.76 Å resolution crystal structure of glycogen phosphorylase B complexed with glucose, and CP320626, a potential antidiabetic drug NG Oikonomakos, SE Zographos, VT Skamnaki, G Archontis Bioorganic & medicinal chemistry 10 (5), 1313-1319, 2002 | 49 | 2002 |
| Phytogenic polyphenols as glycogen phosphorylase inhibitors: the potential of triterpenes and flavonoids for glycaemic control in type 2 diabetes G A Stravodimos, B A Chetter, E Kyriakis, A L Kantsadi, ... Current medicinal chemistry 24 (4), 384-403, 2017 | 48 | 2017 |
| The structure of phosphorylase kinase holoenzyme at 9.9 Å resolution and location of the catalytic subunit and the substrate glycogen phosphorylase C Vénien-Bryan, S Jonic, V Skamnaki, N Brown, N Bischler, ... Structure 17 (1), 117-127, 2009 | 47 | 2009 |
Demetres LeonidasProfessor of Biochemistry, Department of Biochemistry and Biotechnology, University of ThessalyVerified email at bio.uth.gr
